DNA controlled self assembly of nanoparticles

DNA is being used to control nanoparticle self assembly

Learning how to control and tailor the assembly of nanoparticles, which have dimensions on the order of billionths of a meter, could potentially lead to applications ranging from more efficient energy generation and data storage to cell-targeted systems for drug delivery. “We can synthesize nanoparticles with very well controlled optical, catalytic, and magnetic properties,” Maye said. “They are usually free-flowing in solution, but for use in a functional device, they have to be organized in three dimensions, or on surfaces, in a well-controlled manner. That’s where self assembly comes into play. We want the particles to do the work themselves.

The research group previously used rigid, double-stranded DNA to speed up and slow down the speed of nanoparticle assembly. Most recently, they also perfected a method for regulating the size of the resulting particle clusters by incorporating multiple types of DNA strands.

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