Caltech: Lesion Mapping of Cognitive Abilities Linked to Intelligence

Here is a 12 page pdf with supplemental information to the research paper on “Lesion Mapping of Cognitive Abilities Linked to Intelligence”. They identified the parts of the brain that are used for verbal comprehension, perceptual organization, working memory and processing speed.

The Wechsler Adult Intelligence Scale (WAIS) assesses a wide range of cognitive abilities and impairments. Factor analyses have documented four underlying indices that jointly comprise intelligence as assessed with the WAIS: verbal comprehension (VCI), perceptual organization (POI), working memory (WMI), and processing speed (PSI). We usednonparametric voxel-based lesion-symptom mapping in 241 patients with focal brain damage to investigate their neural underpinnings. Statistically significant lesion-deficit relationships were found in left inferior frontal cortex for VCI, in left frontal and parietal cortex for WMI, and in right parietal cortex for POI. There was no reliable single localization for PSI. Statistical power maps and cross-validation analyses quantified specificity and sensitivity of theindex scores in predicting lesion locations. Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease.

Brain Map has Almost Millimeter Cube Volume Precision
43 patients underwent computerized axial tomography (CT) scans and for 198 patients highresolution anatomical T1 weighted images were acquired on a 1.5 T General Electric Signa scanner with a 3D SPGR sequence. A total of 124 coronal slices were acquired (in-plane resolution 1×1 mm, inter-slice distance 1.6 mm, field of view 24 cm).

They statistically correlated how much each piece (voxel) of brain in each specific location correlates to intelligence.

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