click on the roadmap image to enlarge
The PDF roadmap for regenerative medicine is a document assembled by the PhD-laden Russian volunteers at the Science for Life Extension Foundation.
This covers the large areas of interest for cell therapies: (a) removing unwanted cells, such as the growing senescent cell population in every older body, (b) adding cells where they have been lost, so as to reverse sarcopenia, for example, or replace the dying motor neurons that cause the symptoms in a number of unpleasant degenerative conditions, (c) reprogramming cells to create unlimited sources of stem cells or specialized cells to order, (d) restoring the ability for cells to regenerate damage in the body, an ability gradually lost with age, and (e) the use of larger scale tissue engineering to create new replacement organs when needed.
Dawn of the Age of Tissue Engineering
Doctors seek heart valve that grows with kids
Hanley is one of a handful of researchers around the country trying to build a heart valve made of living human tissue that would grow with a child and repair itself over time. It’s a remarkably complicated task that incorporates stem cell science and biomechanical engineering, and an understanding of exactly how tissues grow and function amid the constant rush of blood in a beating heart – and scientists have been stuck on it for more than a decade.
Researchers at the Bernard O’Brien Institute of Microsurgery in Melbourne, Australia are pioneering a radical new surgical procedure that would allow women to re-grow breasts after undergoing a mastectomy, a cancer treatment that removes part or all of a cancerous breast. After a decade of experiments in the laboratory as well as numerous tests on animal models, the researchers are ready to begin clinical trials to test the procedure in humans in the next few months. If all goes as planned, this treatment might become available within 3 years, providing an alternative to breast implants and reconstructive surgery for breast cancer patients.
Doctors would first implant a biodegradable scaffold that is in the shape of a breast. Next, they would introduce fat stem cells into the area and nearby blood vessels would be redirected towards the implanted stem cells in order to supply necessary nutrients. Within 6 – 8 months, the cells are expected to grow and fill the area enclosed by the scaffold, which is then broken down by the body.