Researchers at the Technion-Israel Institute of Technology have discovered a way to reverse the aging process by removing old B lymphocytes (a type of white blood cell in the vertebrate immune system) from old mice, and forcing the production of young, potent cells to replace them. The findings were reported in the January 2011 issue of the scientific journal “Blood.”
As is the case with the rest of the body, the immune system is weakened with age, a fact reflected by a significant increase in illness among the elderly, and a dramatic decrease in their ability to respond to vaccination. The B lymphocytes are major cellular components in the function of the immune system and are responsible for the production of antibodies. According to Prof. Melamed, many studies have shown the B cell population undergoes dramatic changes with age as a result of a decline in the body’s ability to produce new B cells and a selection process that leads to an accumulation of old B cells with a limited and reduced response capability.
Using old mice, the Technion researchers showed that active removal of the B cells changes the cellular homeostasis in the body and generates conditions of chronic deficiency of these cells. To overcome this deficiency, the body re-activates the bone marrow, forcing it to produce B cells again at a rate not different than that which exists in young mice. The researchers found that the newly generated B cells replaced the old cells that were removed, and led to an improvement of up to 400% in the ability of the treated mice to respond to vaccinations.