June 27, 2011

Foresight 2011 - Mesoporous Sensors: From Explosives to Cancer

Mesoporous Sensors: From Explosives to Cancer
Robert Meagley, PhD, CEO/CTO of ONE-Nanotechnologies LLC

One-nanotechnologies website - We create faster, more accurate, and more cost-effective tools for biomarker analysis, making more efficient and precise human health diagnostics possible. Our patent-pending technology measures proteins and other disease and cancer biomarkers through the use of precisely printed photonic nanodevices.

Early disease detection uses biochemical processes to find biomarkers. These biochemicals add complexity, variability and error to the results. Specificity and simplicity are better! Our technology provides both specificity and simplicity without use of antibodies. Our chips are optimized for the detection of particular breast cancer, colorectal cancer, lung cancer and ovarian cancer, as well as heart disease biomarkers. These five diseases are responsible for the majority of non-accident death in Europe and North America.

Extending our thin films technology into the realm of chemical threat detection, our approach has been shown to be an effective discrimination system for biochemical and energetic materials. Nerve agent surrogates and RDX have been identified as trace constituents in air and water. Electronic discrimination of chemical and biochemical threats addresses key issues in environmental health and safety as well as food security and military applications.

* fault tolerant systems
* using plasma processing to spray thin coatings
* plasma cleaning
* vacuum plasma spray
* 350 watts plasma enhanced CVD (chemical vapor deposition)

* embedded sensor technology for chemical detection and food safety
* lower cost systems

Our approach to selecting and detecting specific proteins (and other biomarkers) uses arrays of photonic devices that include host structures for these specific proteins. These unique structured arrangements we term Organized Nano Environments (ONE), hence our name. The use of the ONE photonic nanodevice arrays enables high sensitivity and specificity in biomarker detection.

Our chemical sensors for nerve agents and high-energy materials (i.e. RDX, TNT, etc) are designed around the same “Organized Nano-Environment” approach (ONE technology) as our protein sensors: tailored morphology to create high surface area hosts for the chemical guests. This ONE film comprises a nanocomposite: nano-scale host particles are co-deposited on the sensor platforms with polymers that tune the surface energy of the resulting films to yield engineered materials that recognize specifically the target chemical. The sensor platforms may be vibrating crystals, capacitive arrays and/or optical devices.

We build our films through a highly conformal electrospray coating process that accommodates the three dimensional structure of the sensor platform (a vibrating crystal or a capacitive network). In electrospray, liquid precursor containing the matrix monomer and nano-filler is charged to several thousand volts. The potential overwhelms surface tension of the liquid and forms a very fine spray of droplets that shrink further as solvent evaporates- giving sub micron droplets ensuring a uniform deposition of unique morphology. Coatings may be deposited on insulators, semiconductors and metals. Using our proprietary dual-dep technology, incompatible materials may be deployed in a nanocomposite that retains desirable properties from each component

200 nm scale

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