July 16, 2015

Breeding improvement in animals for insight into genetic enhancement for humans and looks positive for Transhuman genetic engineering of superintelligence

Selective breeding has been used on animals for hundreds of years and statistical methods for breeding selection has been used for over one hundred years.

“Over the past 15 years, sprinters have improved faster than over the previous 150 years,” says Patrick Sharman of the University of Exeter.

Sharman and Alastair Wilson, also at Exeter, analysed 616,084 race times in the UK by 70,388 horses between 1850 and 2012. They then took a closer look at races between 1997 and 2012, for which more extensive and accurate data was available, including the speeds of non-winners inferred from finishing times.

The results show that since 1850, the speeds of winning horses in elite races have improved by 9-13 per cent, depending on the distance run. Winning horses now run between 1.5 and 2 meters per second faster than their counterparts did in 1850.

In the period between 1997 and 2012, sprinters improved most, adding 0.1 per cent to their speeds per year. Non-winners improved, too, adding between 0.03 and 0.09 per cent to their speeds per year.

A 2012 horse would beat a 1997 horse in a sprint race by around 17 meters. The average winning margin in elite races is just 3 meters.

“The annual rates of improvement are very small, despite the attentions not only of breeders and genetic improvement but also of vets, nutritionists and other animal scientists,” says William Hill of the University of Edinburgh. “It contrasts with rates of improvement in farm livestock, with annual genetic change in growth of broilers and milk yields of cattle exceeding 1 per cent a year.”

Various studies on human twins show many traits there is no detectable non-additivity. That is, gene-gene interactions seem to be insignificant, and a simple linear genetic architecture is consistent with the results.

Linear predictive models in animal breeding for over one hundred years.

This means that as we sequence and compare genes for millions of people around 2020-2022 then we will identify the thousands of genes involved in intelligence. These intelligence genes will mostly be additive. We can identify the good genes that contribute to make people more intelligent.

Studies of more than 1 million people will be needed to find enough common gene variants to explain 15% of the variation across people in IQ scores, educational attainment and other behavioral traits. About 60% of intelligence seems to have a genetic basis. If the genetics is mostly linearly then identifying the intelligence genes means we can alter those genes with genetic engineering and create geniuses.

Selecting for intelligence or genetically engineering for intelligence will require larger studies to identify the genes and more genes will need to be altered to achieve the enhancement

I gave a talk at Transhuman Visions early in 2014.

In my look at near term transhumanism, I see older Tiger Moms as being the driver of early adoption of genetic intelligence enhancement and the lifting of the One child policy in China.

China's One child policy is being lifted just as embryo selection based upon intelligence for invitro fertilized (IVF) babies becomes possible and we are on the cusp of genetic engineering. Women in China who are now older were banned from having babies but now will be allowed to have children. Many will not be able to conceive naturally and will use IVF. I see IVF going from 400,000 per year worldwide to 2-8 million per year over the next 10 years. IVF babies are more easily embryo selected and accessible for genetic modification. This would provide an economic boost to China in 20-30 years and the beginnings of a significant societal shift.

* Older women use IVF more than younger women.
* Societal shifts that cause more older women to use IVF to have children means more opportunity for embryo selection and genetic intelligence enhancement.
* Countries that permit embyro selection and genetic intelligence enhancement provide the opportunity for IVF to be used for enhancement
* Medical tourism to permissive countries is another means for older women to use IVF in combination with embryo selection or genetic enhancement.

In my talk I first summarized enhancement of human capabilities via products that we can buy. (Smartphones, Google Glass, Apple Siri, IBM Watson, forklifts, cars etc...) As those things get better, anyone can adopt them by buying the latest versions.

Steroids do enhance performance. They work. About 10 million people use them and it is primarily because of vanity. However, we do not live in the wild west or have to compete as Gladiators in Rome. The more powerful people in the world are the billionaires. In the real world the equivalent of Montgomery Burns from the Simpsons has more power than the equivalent of Captain America. Burns can hire his own police force or mercenaries. It is his lawyers and lobbyists who do his work.

100 years ago it was vaccines that began altering the physical attributes of people in a meaningful way. It extended lifespans and improved health. Health improvement boosted productivity and GDP.

I make the case that studies show that more intelligence leads to better lives for people. They go to jail less. Their jobs are better and they divorce less.

Each one-point increase in a country’s average IQ, the per capita GDP was $229 higher. It made an even bigger difference if the smartest 5 percent of the population got smarter; for every additional IQ point in that group, a country’s per capita GDP was $468 higher. This is according to Are the Wealthiest Countries the Smartest Countries? (Heiner Rindermann, of the Chemnitz University of Technology, Psychological Science )

However, we can see the damage when intelligence is lower across large national populations.

48% of children in India are stunted. Diseases can leave brain damage when they do not kill. This reduces IQ points by 11-20 on average across the country. This makes India more poor.

Embryo Selection

* In Vitro Fertilization (IVF) currently is used for 400,000 babies each year.
* A new "Alka Seltzer method" for controlling PH reduces costs from $10K-20K in developed world to about $1K
* Developing world was $2-4K and can be $200
* Comprehensive Chromosome Screening (about $6000) can boost successful IVF by 10-20%

--> Lower costs for IVF means more adoption and widespread basic genetic screening via chromosome screening will already be used for high IVF success rate

* China lifting one child ban
* This will mean annual birthrates will go from about 16 million ==> 25.5 million
* 23-42 normal child bearing age
* IVF at older ages up to 50-55 now at about 5-15% but improving
* More older women in China will use IVF
* China is not culturally against enhancing children (a lot of tiger moms and cultural differences)
* Lower cost and more effective IVF with standard chromosome screening, easy step to gene screening
* Maybe 4 million IVF/year with gene screening

Children tend to fall within a spread of 13 IQ points above and below the average IQ of their parents.
Positive outlier at around 2 or 3 percent where child is two standard deviations above parents
Pick the smartest genome from a batch of, say, 20 embryos (but it could 50 or more embryos) to get 20-30 IQ points higher
We are technologically close to non-destructive sequencing of human gametes and zygotes by sequencing 10-20 cells.

Genetic Engineering for Intelligence

BGI (Beijing Genomics institute has a large intelligence study of thousands of geniuses
Various studies finding genes with up to 0.5% impact on intelligence
Intelligence is 40-80% inheritable
There are likely hundreds to a thousand thousands to tens of thousands of genes that genetically determine intelligence
This is twenty times more complex than height. According to Steve Hsu's estimates (based on actual data) most humans have (order of magnitude) 1000 rare (-) alleles for height. So about 20,000 rare alleles for intelligence.

One standard deviation above average has (very roughly) 30 fewer (-) variants.
No negative alleles might be 30 SD above average! Such a person has yet to exist in human history...
Each standard deviation (SD) up or down are defined as 15 IQ points greater or less,
95 percent of the population scores an IQ between 70 and 130, which is within two standard deviations of the mean.
30 SD above average would be and IQ of 550.

Maybe IQ 550 is Impossible or Meaningless

550 IQ would be like a 13 foot tall person
Physiology limits practical height
What are intelligence limits ?
Brain structure
Average human height is 70 inches and 3 inch SD (standard deviation)
8 feet 1 inch – 97 inches this is 9 Standard Deviations over average
235 IQ is the equivalent in intelligence of a 8 foot 1 inch person

Geniuses and Society

5% of population with 30 points higher intelligence might be about $14000 more GDP per capita
5% of population with 120 points higher intelligence might be about $56000 more GDP per capita
What would a society with tens of millions of Edisons, Einsteins, Steve Jobs and Elon Musks be like ?
Could we get beyond them in capability?

5% of population significantly intelligence enhanced would be possible if IVF takes off and embryo selection and genetic engineering with it over the next 10-20 years.

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