Joslin Diabetes Center turned off the fat insulin receptor gene that tells you to hold on to every calorie in your fat cells. That was a good idea 10,000 years ago when our genes evolved, because the next hunting season might not work out so well. But today it underlies an epidemic of obesity, diabetes and heart disease. We’d like to turn that gene off. They tried it in animal experiments. The animals ate ravenously but remained slim. They didn’t get diabetes. They didn’t get heart disease. They also lived 20 percent longer. And that’s just one example of 23,000 genes.
We’re involved with a company where we add a gene to people who are missing a gene that causes a terminal disease called pulmonary hypertension, and the treatment has actually worked in human trials. We can subtract genes. We can modify stem cells to have desirable effects such as rejuvenating the heart if it’s been damaged in a heart attack, which is true of half of all heart attack survivors.
We’ll soon have the ability to rejuvenate all the body’s tissues and organs and develop drugs targeted specifically at the underlying metabolic process of a disease rather than taking a hit-or-miss approach. But nanotechnology is where we really move beyond biology.
By the 2020s we’ll start using nanobots to complete the job of the immune system. Our immune system is great, but it evolved thousands of years ago when conditions were different. It was not in the interest of the human species for individuals to live very long, so people typically died in their 20s.
The life expectancy was 19. Your immune system, for example, does a poor job on cancer. It thinks cancer is you. It doesn’t treat cancer as an enemy. It also doesn’t work well on retroviruses. It doesn’t work well on things that tend to affect us later in life, because it didn’t select for longevity.
We can finish the job nature started with a nonbiological T cell. T cells are, in fact, nanobots—natural ones. They’re the size of a blood cell and are quite intelligent. I actually watched one of my T cells attack bacteria on a microscope slide. We could have one programmed to deal with all pathogens and could download new software from the internet if a new type of enemy such as a new biological virus emerged.
As they gain traction in the 2030s, nanobots in the bloodstream will destroy pathogens, remove debris, rid our bodies of clots, clogs and tumors, correct DNA errors and actually reverse the aging process. One researcher has already cured type 1 diabetes in rats with a blood-cell-size device.
Ray believes we will reach a point around 2029 when medical technologies will add one additional year every year to your life expectancy. By that he don’t mean life expectancy based on your birthdate but rather your remaining life expectancy.
SOURCE - Playboy