July 07, 2016

3D printed Silk Micro-rockets are a major breakthrough in drug delivery

Sheffield engineers make major breakthrough in developing silk ‘micro-rockets’ that can be used safely in biological environments.

By using an innovative 3D inkjet printing method, researchers from Chemical and Biological Engineering at the University of Sheffield have taken the biggest step yet in producing microscopic silk swimming devices that are biodegradable and harmless to a biological system.

This means that these devices have the potential to be used in the human body in the future in applications such as drug delivery and locating cancer cells.

This new technique allows the researchers to use safer, non-toxic materials, meaning the micro-rockets will not cause harm or injure any living tissue or biological environment. This is a significant development as previous devices have been expensive to produce, complicated to manufacture and made from polystyrene beads, carbon nanotubes or metals which have to be covered in a catalyst layer (such as platinum) to be able to swim successfully, these devices are usually less friendly to the biological environment they are placed in.

The rockets are just 300 microns in length and 100 microns in diameter, the thickness of a single human hair, and create their own thrust, allowing them to ‘swim’ through any bio fluid containing the fuel.



Small Journal - Reactive Inkjet Printing of Biocompatible Enzyme Powered Silk Micro-Rockets




This is the first time these micro-rockets have been produced using a new reactive inkjet printing method, using a solution of dissolved silk mixed with an enzyme. This solution is then placed into a 3D inkjet printer, which, similar to normal inkjet printing, builds up layers of ink to create a column of the rocket.

By printing methanol on top of the printed solution it triggers a reaction which forms rigid rocket shape which traps the enzyme within a silk lattice structure. This enzyme acts as a catalyst, reacting with fuel molecules to produce bubbles that propel the rocket forward.

Using an enzyme as a catalyst and silk to form the rocket, produces a much safer device that is biodegradable, cheaper and simpler to makeway, removing a major barrier to micro-rockets becoming a reality outside of the lab.



Dr Xiubo Zhao, from The Department of Chemical and Biological Engineering at Sheffield states: “By using a natural enzyme like catalase and silk which are fully biodegradable, our devices are far more biocompatible than earlier swimming devices.”

“The inkjet printing technique also allows us to digitally define the shape of a rocket before it’s produced. This makes it a lot easier to optimise the shape in order to control the way the device swims.”



Abstract

Inkjet-printed enzyme-powered silk-based micro-rockets are able to undergo autonomous motion in a vast variety of fluidic environments including complex media such as human serum. By means of digital inkjet printing it is possible to alter the catalyst distribution simply and generate varying trajectory behavior of these micro-rockets. Made of silk scaffolds containing enzymes these micro-rockets are highly biocompatible and non-biofouling.

Production of small-scale devices that can autonomously generate thrust via catalytic reactions within fluidic environments has become an increasingly active field of research over the last ten years. Recently, this has led to a focus on potential applications including environmental monitoring and remediation, in vivo drug delivery and repair, and lab on a chip diagnostics. Here, we present inkjet printing as a means to realizing these envisaged goals, and as an alternative to the current time-consuming lab scale lithographic fabrication processes. The conventional lithographic approach to control the shape and material distribution within small-scale devices places significant limits on scalability and prevents responsive design and testing. Instead, we show here how embracing advances in printable materials and printing technology can allow rapid, scalable manufacture of digitally defined “micro-rocket” devices, which by virtue of the use of a silk scaffold show promising biocompatibility suggesting suitability for a wide range of future applications.

SOURCES- University of Sheffield, Youtube, Journal Small

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