As life expectancies around the world increase, so are the number of people who will experience age-related cognitive decline. The amount of oxygen in the blood declines with age. Aging in the brain might be naturally held at bay by adenosine receptor A2B (ADORA2B), a protein on the membrane of red blood cells which is …
A researcher has discovered an alternative signaling pathway that is compatible with regeneration of tissues. This could ultimately lead to regenerative medicine therapies for humans. This could help us to create therapies that improve clinical outcomes in diseases in which scarring plays a major role in the pathology, including heart, kidney, liver, and lung disease. …
3D printed implants are soft bridges that guide new nerve cells to grow across a tear or break in an injured spinal cord and restored movement. The work has so far shown promise in rats with severe spinal cord injury. The implants are hydrogel structures that can be rapidly 3D printed into different sizes and …
A team of scientists designed a device that can induce partial hindlimb regeneration in adult aquatic African clawed frogs (Xenopus laevis) by “kick-starting” tissue repair at the amputation site. They introduce a new model for testing “electroceuticals,” or cell-stimulating therapies. “At best, adult frogs normally grow back only a featureless, thin, cartilaginous spike,” says senior …
Within 5 years, the world could widely accept that we are within striking distance of a post-aging world. This could be with the achievement of mice that would normally die at the age of three getting life extension at the age of two and living beyond 5 years. It might be after that with the …
Juvenescence will purchase, in a single transaction, 14.4 million shares of AgeX Therapeutics from BioTime for $43.2 million. 50% of the purchase price will be paid to BioTime in cash and the remaining 50% will be a 2-year convertible/redeemable note with an annual interest rate of 7%, payable at maturity. Juvenescence is developing multiple therapeutics …
Samumed has raised $438 million with a $12 billion valuation. Samumed is a leader in medical research and development for tissue-level regeneration. They have a biotechnology platform based on small molecule-based Wnt pathway modulation, they develop therapeutics to address a range of degenerative diseases, regenerative medicine and oncology. One of the primary signaling pathways that …
Michael West explains his theory that the body normally gets rid of senescent cells when we are younger because the body has enough rejuvenation to replace the cells. However, the older body cannot replace the cells as easily so the body says wait lets keep those heart cells or other cells because I cannot replace …
Researchers at the Stowers Institute for Medical Research have captured the one cell that is capable of regenerating an entire organism (flatworm). These used a technique that combines genomics, single-cell analysis, flow cytometry and imaging, scientists have isolated this amazing regenerative cell – a subtype of the long-studied adult pluripotent stem cell – before it …
Paul Sharpe, a bioengineer at King’s College London, and his colleagues discovered a new way regenerate teeth in mice. They have made even more progress that edges this experimental procedure closer to human clinical trials. If the teeth regeneration treatment eventually becomes part of the dentist’s standard toolkit, then it would easily be one of …
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury – and getting them to stay there – remains challenging. In a new pilot study using an animal model, North Carolina State University researcher Ke Cheng and his team show that “decorating” cardiac …