A Zinc finger proteins (ZFP) is a sequence of small protein structures (the fingers) that, taken together, bind to a specific DNA sequence. Unlike oligonucleotides, which bind to the Watson-Crick interface of single-stranded DNA, ZFPs bind in the major groove of double-stranded DNA (dsDNA), recognizing DNA base pairs from the side. They’re modular and can be engineered to target sequences chosen by a designer. This is an enabler for the DNA/protein/special-structure approach to modular molecular composite nanosystems.
Drexler Take-away messages:
* Paths are now open toward complex,self-assembled, heterogenous nanosystems
* Diverse problems are ready for work, and their solutions will support a new technology base