* The cost of DNA origami is from 1,000$ to 10,000$ per nmol. The scaffold strand dominates the total cost (80%).
* The method cannot be scaled up arbitrarily
– requires scaffolds of larger size.
– sequences of staple strands should be unique.
Design of Scaffolded DNA Origami
a. the target shape
b. discrete approximation
c. hand-engineered folding path
d. staple strand geometry
e. generated staple strand DNA sequences
[synthesize the staple strands]
[mix the scaffold and staple strands]
f. the resulting shape as seen from atomic force microscope
Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.
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