Out of 10 patients, only two patients have not gotten better on the T cell therapy, even though all had stopped responding to conventional treatments. Four patients have had a complete response – their leukemia was eradicated – with the longest so far lasting 28 months. In four other patients, leukemia diminished dramatically.
This is the same treatment that was described in a Nextbigfuture article yesterday. Novartis has the rights to this and is developing it.
“We believe we know why the two patients didn’t respond,” said Penn physician David L. Porter, a cancer and blood specialist. “If we’re right, it’s something we can fix.”
The therapy, culminating 20 years of research, involves genetically engineering T cells – the immune system’s big guns – to attack B cells, the blood component that turns malignant in chronic lymphocytic leukemia and acute lymphoblastic leukemia.
Interfering with the immune system, however, is dicey. From the start, it was clear the designer T cells had side effects that caused flulike symptoms.
The modified T cells can attack the patients B cells and set off a self-destructive chain reaction.
The T cells flood the body with signaling chemicals called cytokines, particularly interleukin 6. The interleukin, in turn, stimulated cells called macrophages that normally consume cellular debris.
The macrophages can go on a rampage and consume the patients red blood cells.
A drug tocilizumab (Actemra), a new rheumatoid arthritis drug can stop the dangerous side effects.
Doctors now know how to manage the side effects and they are determining when to provide Actemra to reverse the T cells.
SOURCE – Philly Inquirer
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Wang is a prolific business-oriented writer of emerging and disruptive technologies. He is known for insightful articles that combine business and technical analysis that catches the attention of the general public and is also useful for those in the industries. He is the sole author and writer of nextbigfuture.com
, the top online science blog. He is also involved in angel investing and raising funds for breakthrough technology startup companies.
He gave the recent keynote presentation at Monte Jade event with a talk entitled the Future for You. He gave an annual update on molecular nanotechnology at Singularity University on nanotechnology, gave a TEDX talk on energy, and advises USC ASTE 527 (advanced space projects program). He has been interviewed for radio, professional organizations. podcasts and corporate events. He was recently interviewed by the radio program Steel on Steel on satellites and high altitude balloons that will track all movement in many parts of the USA.
He fundraises for various high impact technology companies and has worked in computer technology, insurance, healthcare and with corporate finance.
He has substantial familiarity with a broad range of breakthrough technologies like age reversal and antiaging, quantum computers, artificial intelligence, ocean tech, agtech, nuclear fission, advanced nuclear fission, space propulsion, satellites, imaging, molecular nanotechnology, biotechnology, medicine, blockchain, crypto and many other areas.