The Independent UK is hailing the CRISPR gene editing process as a breakthrough in genetics – described as “jaw-dropping” by one Nobel scientist – has created intense excitement among DNA experts around the world who believe the discovery will transform their ability to edit the genomes of all living organisms, including humans.
* they say it is only a matter of time before we are eliminating genetic disease in human embyros
* human trials to eliminate genetic diseases are starting
* Rare double mutants in the myostatin gene have more lean muscle and less body fat
* those with the LRP5 gene have extra strong bones (like the real version of the Bruce Willis movie Unbreakable character
* Those with the PCSK5 gene have 88 percent lower coronary disease
* Those with double CCR5 genes are HIV resistant
* Those with double FUT2 are resistant to stomach flu
George Church has indicated that we are years from successful regeneration and anti-aging. He has also talked about radically altering human DNA on a genomic scale to achieve increased intellectual, health and physical capabilities.
With Walter Gilbert, Geroge Church developed the first direct genomic sequencing method in 1984 and helped initiate the Human Genome Project in 1984 while he was a Research Scientist at newly formed Biogen Inc. George invented the broadly applied concepts of molecular multiplexing and tags, homologous recombination methods, and DNA array synthesizers. Technology transfer of automated sequencing & software to Genome Therapeutics Corp. resulted in the first commercial genome sequence, (the human pathogen, Helicobacter pylori) in 1994.
George initiated the Personal Genome Project (PGP) in 2005, and, in 2007, he founded the U.S. personal genomics company Knome (with Jorge Conde and Sundar Subramaniam). He does research on synthetic biology and is director of the U.S. Department of Energy Center on Bioenergy at Harvard & MIT and director of the National Institutes of Health (NHGRI) Center of Excellence in Genomic Science at Harvard.
George Church has been advisor to 22 companies, co-founding (with Joseph Jacobson, Jay Keasling, and Drew Endy) Codon Devices, a biotech startup dedicated to synthetic biology, which produces DNA sequences to order. With Chris Somerville, Jay Keasling, Noubar Afeyan, and David Berry he founded LS9, which is focused on biofuels or renewable petroleum technologies.
In 2009 he founded Pathogenica, with Yemi Adesokan, in order to pioneer commercial applications for pathogen sequencing technology.
He has authored and co-authored more than 270 publications and 50 patent
In addition to engineering the genes of plants and animals, which could accelerate the development of GM crops and livestock, the Crispr technique dramatically “lowers the threshold” for carrying out “germline” gene therapy on human IVF embryos, Professor Mello added.
The new gene-editing technique could address many of the safety concerns because it is so accurate. Some scientists now believe it is only a matter of time before IVF doctors suggest that it could be used to eliminate genetic diseases from affected families by changing an embryo’s DNA before implanting it into the womb.