Researchers compared the health-spans of older generation subjects of the Long Life Family Study (LLFS) to controls without family history of longevity and to centenarians of the New England Centenarian Study (NECS) using Bayesian parametric survival analysis. We estimated hazard ratios, the ages at which specific percentiles of subjects had onsets of diseases, and the gain of years of disease-free survival in the different cohorts compared to referent controls. Compared to controls, LLFS subjects had lower hazards for cancer, cardiovascular disease, severe dementia, diabetes, hypertension, osteoporosis, and stroke. The age at which 20% of the LLFS siblings and probands had one or more age-related diseases was approximately 10 years later than NECS controls.
The Long Life Family Study (LLFS) is an ongoing study of longevity and healthy aging in 583 families and almost 5000 family members demonstrating clustering for longevity. Median age of the probands and their siblings (the older generation or “generation one”) at enrollment was 92 years with an age range of 72–109 years. This substantial longevity was associated with decreased prevalence of age-related diseases such as diabetes and peripheral artery disease compared to subjects in the Framingham Heart Study and Cardiovascular Health Study
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