KL-VS gene makes up six IQ points of cognitive difference and would be the most influential intelligence gene and elevated intelligence could come soon from a pill

Researchers have been studying the role in ageing of klotho, a protein encoded by a gene called KL. A particular version of this gene, KL-VS, promotes longevity. One way it does so is by reducing age-related heart disease. Dr Dubal and Dr Mucke wondered if it might have similar powers over age-related cognitive decline.

What they found was startling. KL-VS did not curb decline, but it did boost cognitive faculties regardless of a person’s age by the equivalent of about six IQ points. If this result, just published in Cell Reports, is confirmed, KL-VS will be the most important genetic agent of non-pathological variation in intelligence yet discovered.

Dr Dubal and Dr Mucke made their discovery when they looked at 220 volunteers aged 52 to 85, to study the effects of KL-VS on ageing. They assessed their volunteers’ faculties of memory, attention, visuo-spatial awareness and language. From these, they constructed a composite measure of cognition.

That measure suggested people with a VS version of the KL gene in their chromosomes had better cognition than those without one. When they analysed data collected by two other groups who work independently on KL-VS they discovered these researchers had found the same thing. That comparison brought the number of people examined to 718, a fifth of whom were possessors of KL-VS.

The six-point IQ gap is an extrapolation, since the cognitive tests did not measure general intelligence directly. But if it is correct, variation in the KL gene could account for as much as 3% of the variation of IQ in the general population (or, rather, in the population from which the researchers’ samples were drawn, namely white Americans). In comparison, the previous record-holders, HMGA2 and NPTN, each account for only half a percent of that variation.

A drug that elevates klotho levels, or mimics that protein’s function, might indeed enhance cognition, and there is no obvious reason why such a drug should be restricted to the elderly. If it could be developed everyone—except, maybe, those already in possession of a copy of KL-VS in their genes—might be able to take pills to make themselves a little brighter.

KL-VS and some of the other genes are currently at about 5% IQ variation and could be used for embyro selection or for genetic engineering.

Embryo Selection

* In Vitro Fertilization (IVF) currently is used for 400,000 babies each year.
* A new “Alka Seltzer method” for controlling PH reduces costs from $10K-20K in developed world to about $1K
* Developing world was $2-4K and can be $200
* Comprehensive Chromosome Screening (about $6000) can boost successful IVF by 10-20%

–> Lower costs for IVF means more adoption and widespread basic genetic screening via chromosome screening will already be used for high IVF success rate

* China lifting one child ban
* This will mean annual birthrates will go from about 16 million ==> 25.5 million
* 23-42 normal child bearing age
* IVF at older ages up to 50-55 now at about 5-15% but improving
* More older women in China will use IVF
* China is not culturally against enhancing children (a lot of tiger moms and cultural differences)
* Lower cost and more effective IVF with standard chromosome screening, easy step to gene screening
* Maybe 4 million IVF/year with gene screening

Children tend to fall within a spread of 13 IQ points above and below the average IQ of their parents.
Positive outlier at around 2 or 3 percent where child is two standard deviations above parents
Pick the smartest genome from a batch of, say, 20 embryos (but it could 50 or more embryos) to get 20-30 IQ points higher
We are technologically close to non-destructive sequencing of human gametes and zygotes by sequencing 10-20 cells.

Genetic Engineering for Intelligence

BGI (Beijing Genomics institute has a large intelligence study of thousands of geniuses
Various studies finding genes with up to 0.5% impact on intelligence
Intelligence is 40-80% inheritable
There are likely hundreds to a thousand genes that genetically determine intelligence
Similar to height. According to Steve Hsu’s estimates (based on actual data) most humans have (order of magnitude) 1000 rare (-) alleles for intelligence and height

One standard deviation above average has (very roughly) 30 fewer (-) variants.
No negative alleles might be 30 SD above average! Such a person has yet to exist in human history…
Each standard deviation (SD) up or down are defined as 15 IQ points greater or less,
95 percent of the population scores an IQ between 70 and 130, which is within two standard deviations of the mean.
30 SD above average would be and IQ of 550.

Maybe IQ 550 is Impossible or Meaningless

550 IQ would be like a 13 foot tall person
Physiology limits practical height
What are intelligence limits ?
Brain structure
Average human height is 70 inches and 3 inch SD (standard deviation)
8 feet 1 inch – 97 inches this is 9 Standard Deviations over average
235 IQ is the equivalent in intelligence of a 8 foot 1 inch person

Geniuses and Society

5% of population with 30 points higher intelligence might be about $14000 more GDP per capita
5% of population with 120 points higher intelligence might be about $56000 more GDP per capita
What would a society with tens of millions of Edisons, Einsteins, Steve Jobs and Elon Musks be like ?
Could we get beyond them in capability?

5% of population significantly intelligence enhanced would be possible if IVF takes off and embryo selection and genetic engineering with it over the next 10-20 years.

If you liked this article, please give it a quick review on ycombinator or StumbleUpon. Thanks

Subscribe on Google News