First successful penis transplant

In a ground-breaking operation, a team of pioneering surgeons from Stellenbosch University (SU) and Tygerberg Hospital performed the first successful penile transplant in the world.

The marathon nine-hour operation, led by Prof André van der Merwe, head of SU’s Division of Urology, was performed on 11 December 2014 at Tygerberg Hospital in Bellville, Cape Town. This is the second time that this type of procedure was attempted, but the first time in history that a successful long-term result was achieved.

“South Africa remains at the forefront of medical progress,” says Prof Jimmy Volmink, Dean of SU’s Faculty of Medicine and Health Sciences (FMHS). “This procedure is another excellent example of how medical research, technical know-how and patient-centred care can be combined in the quest to relieve human suffering. It shows what can be achieved through effective partnerships between academic institutions and government health services.”

“Our goal was that he would be fully functional at two years and we are very surprised by his rapid recovery,” says Van der Merwe. The end result of the transplant was the restoration of all the patient’s urinary and reproductive functions.

“It’s a massive breakthrough. We’ve proved that it can be done – we can give someone an organ that is just as good as the one that he had,” says Graewe. “It was a privilege to be part of this first successful penis transplant in the world.”

The 21-year-old patient had his penis amputated three years ago after a botched circumcision at a traditional initiation ceremony.

Prof André van der Merwe announced that surgeons at Stellenbosch University’s Faculty of Medicine and Health Sciences performed the first successful penis transplant in the world. The marathon nine-hour operation was performed on 11 December 2014 at Tygerberg Hospital in Cape Town, South Africa.

“There is a greater need in South Africa for this type of procedure than elsewhere in the world, as many young men lose their penises every year due to complications from traditional circumcision,” explains Van der Merwe.

Three years ago the 21-year-old recipient’s penis had to be amputated in order to save his life when he developed severe complications after a traditional circumcision. Although there are no formal records on the number of penile amputations per year due to traditional circumcision, one study reported up to 55 cases in the Eastern Cape alone, and experts estimate as many as 250 amputations per year across the country.

“This is a very serious situation. For a young man of 18 or 19 years the loss of his penis can be deeply traumatic. He doesn’t necessarily have the psychological capability to process this. There are even reports of suicide among these young men,” says Van der Merwe.

“The heroes in all of this for me are the donor, and his family. They saved the lives of many people because they donated the heart, lungs, kidneys, liver, skin, corneas, and then the penis,” says Van der Merwe. Finding a donor organ was one of the major challenges of the study.

The planning and preparation for the study started in 2010. After extensive research Van der Merwe and his surgical team decided to employ some parts of the model and techniques developed for the first facial transplant.

“We used the same type of microscopic surgery to connect small blood vessels and nerves, and the psychological evaluation of patients was also similar. The procedure has to be sustainable and has to work in our environment at Tygerberg,” says Van der Merwe.

This procedure could eventually also be extended to men who have lost their penises from penile cancer or as a last-resort treatment for severe erectile dysfunction due to medication side effects. As part of the study, nine more patients will receive penile transplants.

Doctors say the man, whose identity has not been disclosed, has made a full recovery since the operation on December 11 and has regained all urinary and reproductive functions.

In 2006, a Chinese man had a penis transplant but his doctors removed the organ after two weeks due to “a severe psychological problem of the recipient and his wife”.

SOURCES – Stellenbosch University, Youtube, MedXpress,

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