Secret of cancer immunity in Elephants are multiple cancer protection genes

Bigger creatures should have more cancer risk. However, Elephants do not have high rates of cancer. They have some kind of protection.

* elephants have 20 extra duplicates of p53, a tumor suppressor gene.
* they also duplicate copies of the LIF gene, which encodes for leukemia inhibitory factor.

Elephant cells commit suicide at the first hint of abnormality.

Above – Lucy Reading-Ikkanda/Quanta Magazine

Biorxiv – A zombie LIF gene in elephants is up-regulated by TP53 to induce apoptosis in response to DNA damage (27 page PDF)