Rejuvenate Bio is a stealth startup that is working on reversing aging in dogs and then will try to reverse aging in humans. George Church is a cofounder. George Church is a Harvard Professor -serial entrepreneur of many multi-million dollar and even billion dollar biotech companies.
* aging reversal test in dog trials in 2018-2019. Human trials would be in 2019-2022 and about 2025 before they are done. Once you get a few going and succeeding it’s a positive feedback loop.
Nextbigfuture initially covered this in November, 2017.
Rejuvenate Bio has carried out preliminary tests on beagles, claims it will make animals “younger” by adding new DNA instructions to their bodies.
“We have already done a bunch of trials in mice and we are doing some in dogs, and then we’ll move on to humans,” Church told the podcaster Rob Reid earlier this year. The company’s other founders are CEO Daniel Oliver and science lead Noah Davidsohn, a postdoc in Church’s sprawling Boston lab.
The US pet industry is a $72-billion-a-year market.
The prolongation of human lifespan is “the biggest thing that is going to happen in the 21st century,” says David Sinclair, a Harvard biologist who collaborates with the Church lab. “It’s going to make what Elon Musk is doing look fairly pedestrian.”
Rejuvenate Bio has met with investors and won a grant from the US Special Operations Command to look into “enhancement” of military dogs while Harvard is seeking a broad patent on genetic means of aging control in species including the “cow, pig, horse, cat, dog, rat, etc.”
The team hit on the idea of treating pets because proving that it’s possible to increase longevity in humans would take too long. “You don’t want to go to the FDA and say we extend life by 20 years. They’d say, ‘Great, come back in 20 years with the data,’” Church said during the event in Boston.
The lab started working through a pipeline of more than 60 different gene therapies, which it is testing on old mice, alone and in combinations. The Harvard group now plans to publish a scientific report on a technique that extends rodents’ lives by modifying two genes to act on four major diseases of aging: heart and kidney failure, obesity, and diabetes. According to Church, the results are “pretty eye-popping.”