Peter Attia has a clinician approach to longevity and discusses Rapamycin dosage

Peter Attia is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. He spoke with Joe Rogan about longevity.

Peter lists three things that can increase longevity.
* Calorie Restriction- nutrient restriction
* Rapamycin taken in a pulsatile way. Suppress mTor1 inhibition without mTor2 inhibition.
2-5 mg every 5 to 7 days is probably the dosage sweet spot.
* fasting

mTor has two variants mTor complex1 and mTor complex 2
Rapamycin taken everyday does not produce longevity.

Rapamycin
David Sabatini lab at MIT
Matt Caberlin
Joan Manik (Novartis)

At 16 minutes, Peter talks about the dosing of Rapamycin and his expected benefits if it is working (his theory).

Glucose levels does not get worse and may get better depending on where you start.
Immune performance should improve.
Autophagy should increase. Peter wants to develop a blood test to find a signature of the amount of autophagy.

BigSpeak Speakers Bureau – Peter Attia – Reverse engineered approach to human longevity

Dr. Peter Attia is a health speaker, researcher, nutrition and longevity expert, and the founder of Attia Medical, PC, a medical practice focusing on the applied science of longevity and optimal performance. His practice applies nutrition science, lipidology, four-system endocrinology, sleep physiology, stress management, and exercise physiology to minimize the risk of chronic disease onset, while simultaneously improving healthspan.

When not helping others, Attia writes the Eating Academy blog, which charts his own adventures in nutrition and examines scientific evidence surrounding food, weight loss and disease risk.

Disease is compounding. The major chronic diseases start 20 years earlier in regular people when compared to centenarians.

There about 12 genes that centenarians have.

* Less ApoC3
* Less PcsK9
* AE2 over 3 or 4
* Less GHR
* Less IGF1 and a few other genes

Big killers of people, 80% die from
– heart and cardiovascular disease
– cancer
– neurodegenerative
– accidents

One third to one half of each condition is preventable with approaches using diet and exercise.

1. Caloric Restriction – Dietary Restriction
2. Rapamycin (mTor)
3. Genetic insights on animals

Another video interview with Peter about Longevity

The transcript for the Found my Fitness interview with Peter Attia is here.

Rhonda: So just for people that don’t know what mTOR is, can you explain why that’s really important?

Peter: Yes. So there are probably, depending on who you talk with, I would say there are two or three major growth pathways in the body that are, kind of, responsible for growth both in the positive sense and in the pathologic sense. The two that I focus on the most are the IGF pathway and the mTOR pathway. Now, mTOR stands for mammalian target of rapamycin. I think for the sake of time I will not tell my favorite story, which is a story that is both the discovery of rapamycin and perhaps more interestingly the elucidation of how it worked. But suffice it to say the compound rapamycin was identified first long before a really amazing guy named David Sabatini as a PhD student at Hopkins in 1993, 1994 as a side project in a lab made the discovery that this thing, rapamycin, was actually working by inhibiting a protein complex of which TOR, target of rapamycin, as it became named was the central piece.

We now know today that it can form onto two complexes. One is called mTOR complex 1 or mTORC1 and the other is mTOR complex 2, mTORC2, and we also know that it exists in different tissues and it has different activities in different tissues. Like most things in the body, too much or too little is a bad thing. So if you have no mTORC1, for example, in your muscles, you’d wither away and that would be a debilitating condition. In fact, for people with muscular dystrophy one of the things you want to do is figure out how to alter that pathway. But similarly, we know that overactivity is predisposing us to aging and, of course, certain diseases of aging like cancer.

…if you want to live longer the name of the game is delaying the onset of the big three, the big three being the diseases that will kill 75% of us, so cerebrovascular and cardiovascular, cancer, and neurodegenerative. And so that brings us back to why we’ve got to have IGF and mTOR in check, because we’ve got to prevent them from being able to, sort of, amplify that.

How to live longer

Dr. Peter Attia, the guest for this episode of STEM-Talk, is a modern-day “Renaissance man,” says IHMC CEO Ken Ford. That term gets tossed around a lot, but in Attia’s case, it’s true. He is a top-notch physician, a former McKinsey consultant, and an ultra endurance athlete—who once swam twenty-something miles to Catalina Island, off the coast of California.

During the podcast show, Attia talks about his academic journey, from studying math and engineering, to then pursuing clinical medicine and developing research interests in longevity. The birth of Attia’s daughter marked his interest in quantity of life—as well as quality of life.

Attia discusses his eight “drivers of longevity,” all of which depart from the concept of preventing the onset of chronic disease. These include optimal nutrition, exercise, sleep habits, hormone optimization, stress management, sense of purpose/social connections, medications, and avoidance of harmful behaviors.

Peter’s website is here.

Peter had a TED talk about Diabetes

Could the precursors to diabetes cause obesity, and not the other way around? A look at how assumptions may be leading us to wage the wrong medical war.

Peters talk about dietary guidelines

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