Improving flow in lymph nodes in the neck improves memory and learning and could reduce memory loss from aging

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The lymphatic vessels long thought not to exist are essential to the brain’s ability to cleanse itself. UVA researchers were able to use a compound to improve the flow of waste from the brain to the lymph nodes in the neck of aged mice. The vessels became larger and drained better, and that had a direct effect on the mice’s ability to learn and remember.

This is the first time that we can actually enhance cognitive ability in an old mouse by targeting this lymphatic vasculature around the brain.

The researchers determined that obstructing the vessels in mice worsens the accumulation of harmful amyloid plaques in the brain that are associated with Alzheimer’s. This may help explain the buildup of such plaques in people, the cause of which is not well understood.

They will develop a drug to improve the performance of the lymphatic vessels in people. They signed a contract with biopharmaceutical company PureTech Health to develop a drug.

The best way to treat Alzheimer’s might be to combine vasculature repair with other approaches. Improving the flow through the meningeal lymphatic vessels might even overcome some of the obstacles that have doomed previously promising treatments, moving them from the trash heap to the clinic.

haha anyone can say anything. when you publish a paper, you dare others to reproduce your results with details or potentially be cast wrong, or worst a fake. with a line like you said above, you risk nothing, therefore it means little.

  • haha anyone can say anything. when you publish a paper you dare others to reproduce your results with details or potentially be cast wrong or worst a fake. with a line like you said above you risk nothing therefore it means little.

  • 2015 Researchers Find Missing Link Between the Brain and Immune System””https://neurosciencenews.com/lymphatic-system-brain-neurobiology-2080/”””

  • I wonder if one will have to get a prescription for this after it’s developed…. It doesn’t appear to be a drug that’s habit forming or dangerous…

  • I wonder if one will have to get a prescription for this after it’s developed…. It doesn’t appear to be a drug that’s habit forming or dangerous…

  • If it works, its not meaningless especially if you are staring down the disease. Old remedies and modalities are being proved to be proper working treatments by science all of the time.

  • Manual Lymphatic drainage is a type of modality which increases lymph movement throughout the body. It has been in practice since the 1930’s. A trained massage therapist can provide this treatment without the harmful side effects of prescription medication

  • If it works its not meaningless especially if you are staring down the disease. Old remedies and modalities are being proved to be proper working treatments by science all of the time.

  • Manual Lymphatic drainage is a type of modality which increases lymph movement throughout the body. It has been in practice since the 1930’s. A trained massage therapist can provide this treatment without the harmful side effects of prescription medication

  • SOME old remedies and modalities are proved to be proper working treatments. And when they are, there is a reference you can point to. This is not to say that there aren’t good, working cures that don’t (yet) have scientific backing, or at least a decent reference you can point to. But if someone just mentions such a cure it’s perfectly reasonable to ask for such a reference before just eating whatever some guy on the internet told you to.

  • SOME old remedies and modalities are proved to be proper working treatments. And when they are there is a reference you can point to. This is not to say that there aren’t good working cures that don’t (yet) have scientific backing or at least a decent reference you can point to. But if someone just mentions such a cure it’s perfectly reasonable to ask for such a reference before just eating whatever some guy on the internet told you to.

  • I should clarify how a senolytic works or what I wrote my be counter-intuitive. Senolytics cause the apoptosis (sell-death) of older ‘senile’ cells. When the older cells are removed the healthier cells then increase in number – think ‘growth factor production’ 😉 filling the gaps left by the older cells. Healthier cells also do not attract so much inflammation – which itself can block vessels of all types.

  • Interesting. I wonder if taking Quercitin would help with Alzheimer’s. In research quercitin appears to be an effective senolytic for endothelial cells, and hence would serve to increase the repair and maintenance of lymphatic vessels … a quick search for “quercitin and Alzheimer’s” reveals some solid looking research that makes it appear that it does have protective effects! Maybe this is part of the mechanism? Highlights from one paper: •Quercetin treatment reverses ß-amyloidosis in 3xTg-AD mice. •Quercetin decreases tauopahty in 3xTg-AD mice. •Quercetin reduces astrogliosis and microgliosis in 3xTg-AD mice. •Quercetin improves cognitive function of aged 3xTg-AD mice. •Quercetin exerts an anxiolytic effect on aged 3xTg-AD mice. 3xTg-AD mice == “triple transgenic Alzheimer’s disease model mice”

  • I should clarify how a senolytic works or what I wrote my be counter-intuitive. Senolytics cause the apoptosis (sell-death) of older ‘senile’ cells. When the older cells are removed the healthier cells then increase in number – think ‘growth factor production’ 😉 filling the gaps left by the older cells. Healthier cells also do not attract so much inflammation – which itself can block vessels of all types.

  • Interesting. I wonder if taking Quercitin would help with Alzheimer’s. In research quercitin appears to be an effective senolytic for endothelial cells and hence would serve to increase the repair and maintenance of lymphatic vessels … a quick search for quercitin and Alzheimer’s”” reveals some solid looking research that makes it appear that it does have protective effects! Maybe this is part of the mechanism?Highlights from one paper: •Quercetin treatment reverses ß-amyloidosis in 3xTg-AD mice.•Quercetin decreases tauopahty in 3xTg-AD mice.•Quercetin reduces astrogliosis and microgliosis in 3xTg-AD mice.•Quercetin improves cognitive function of aged 3xTg-AD mice.•Quercetin exerts an anxiolytic effect on aged 3xTg-AD mice.3xTg-AD mice == “”””triple transgenic Alzheimer’s disease model mice”””””””””””

  • The lymphatic system is a closed system that circulates throughout your body including your brain. When lymph is moved it moves throughout it’s entire system.

  • The lymphatic system is a closed system that circulates throughout your body including your brain. When lymph is moved it moves throughout it’s entire system.

  • Google “Lymphatic System”. From the first paragraph of the wikipedia article: “Unlike the circulatory system, the lymphatic system is not a closed system.

  • Google Lymphatic System””.From the first paragraph of the wikipedia article: “”””Unlike the circulatory system”””” the lymphatic system is not a closed system.”””””””

  • Google “Lymphatic System”.
    From the first paragraph of the wikipedia article: “Unlike the circulatory system, the lymphatic system is not a closed system.”

  • I should clarify how a senolytic works or what I wrote my be counter-intuitive. Senolytics cause the apoptosis (sell-death) of older ‘senile’ cells. When the older cells are removed the healthier cells then increase in number – think ‘growth factor production’ 😉 filling the gaps left by the older cells. Healthier cells also do not attract so much inflammation – which itself can block vessels of all types.

  • Interesting. I wonder if taking Quercitin would help with Alzheimer’s. In research quercitin appears to be an effective senolytic for endothelial cells, and hence would serve to increase the repair and maintenance of lymphatic vessels … a quick search for “quercitin and Alzheimer’s” reveals some solid looking research that makes it appear that it does have protective effects! Maybe this is part of the mechanism?

    Highlights from one paper:
    •Quercetin treatment reverses ß-amyloidosis in 3xTg-AD mice.
    •Quercetin decreases tauopahty in 3xTg-AD mice.
    •Quercetin reduces astrogliosis and microgliosis in 3xTg-AD mice.
    •Quercetin improves cognitive function of aged 3xTg-AD mice.
    •Quercetin exerts an anxiolytic effect on aged 3xTg-AD mice.

    3xTg-AD mice == “triple transgenic Alzheimer’s disease model mice”

  • SOME old remedies and modalities are proved to be proper working treatments. And when they are, there is a reference you can point to.
    This is not to say that there aren’t good, working cures that don’t (yet) have scientific backing, or at least a decent reference you can point to. But if someone just mentions such a cure it’s perfectly reasonable to ask for such a reference before just eating whatever some guy on the internet told you to.

  • If it works, its not meaningless especially if you are staring down the disease. Old remedies and modalities are being proved to be proper working treatments by science all of the time.

  • Manual Lymphatic drainage is a type of modality which increases lymph movement throughout the body. It has been in practice since the 1930’s. A trained massage therapist can provide this treatment without the harmful side effects of prescription medication

  • haha anyone can say anything. when you publish a paper, you dare others to reproduce your results with details or potentially be cast wrong, or worst a fake. with a line like you said above, you risk nothing, therefore it means little.

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