Timeline for Anti-aging Treatment Against Senescent Cells

Unity Biotechnology is a biotech leader in developing treatments to eliminating accumulated senescent cells, which are a fundamental mechanism of aging and a driver of many common age-associated diseases. Senescent cells normally destroy themselves via a programmed process called apoptosis, and they are also removed by the immune system; however, the immune system weakens with age, and increasing numbers of these senescent cells escape this process and build up.

The health and lifespan of mice have been demonstrated to improve by the removal of senescent cells using a transgenic suicide gene [3], and additional experiments showed that the same could be achieved using small molecules. A cell becomes senescent when it loses its ability to divide. This happens as a response to DNA damage, and it is thus a sort of safety measure to prevent the proliferation of cells containing potentially harmful mutations, such as cancerous ones.

Senescent cells comprise a small number of total cells in the body, but they secrete pro-inflammatory cytokines, chemokines, and extracellular matrix proteases, which, together, form the senescence-associated secretory phenotype, or SASP. The SASP is thought to significantly contribute to aging and cancer; thus, senolytics and the removal of the SASP are a potential strategy for promoting health and longevity.

In June 2018, Unity Biotechnology started the very first human trial to test senolytic drugs. The UNITY Biotechnology candidate senolytic drug UBX0101 is now being tested in human patients who suffer from osteoarthritis.

* In an interview in 2016, Nathaniel David (CEO, Unity Biotechnology indicated that he thought that the Unity Senolytic drugs would be approved for commercial usage around 2023. He indicated the clinical trials would start at about 2018 and he was right.

* In the video, Nathaniel feels that the various localized versions of senolytics would eventually give confidence to the FDA that eliminating senescent cells throughout the body would be safe and effective and that this could be achieved in the 2030s.

Nathaniel feels that Senolytics by themselves would improve healthspan and reduce age-related diseases in humans.

It will take treatments that are effective against all types of aging damage (identified by Aubrey de Grey and SENS) for significant life extension to occur.

UNITY also has a second drug candidate, UBX1967, an inhibitor of specific members of the Bcl-2 family of apoptosis regulatory proteins, which is slated for an IND application and a Phase 1 clinical study for an ophthalmological indication in the second half of 2019.

95 thoughts on “Timeline for Anti-aging Treatment Against Senescent Cells”

  1. I don’t know; You know what engineers do once they get financially independent? That’s right: They work on what THEY find interesting. The thing is, it takes a long while for an engineer to reach that point most of the time, and by then they’re getting a bit slow, and don’t have a lot of energy. In a world where engineers lived a lot longer, and didn’t decline so much, you’d have a lot of independent engineers working on odd projects, or collaborating on interesting things. You know those consumer 3d printers? They came from such a collaboration…

  2. I don’t know; You know what engineers do once they get financially independent? That’s right: They work on what THEY find interesting.The thing is it takes a long while for an engineer to reach that point most of the time and by then they’re getting a bit slow and don’t have a lot of energy.In a world where engineers lived a lot longer and didn’t decline so much you’d have a lot of independent engineers working on odd projects or collaborating on interesting things.You know those consumer 3d printers? They came from such a collaboration…

  3. Here’s a like. Ya, when you combine Ethics of Madness and Grendel, both by Niven, and that one where the financially strapped protagonist (who, due to financial setbacks can no longer afford longevity drugs) tricks the bad guys into burning stage tree logs, you pretty much get all of them plus Dr Pat’s addition. Not that most of these have not been reinforced by other authors.

  4. Here’s a like. Ya when you combine Ethics of Madness and Grendel both by Niven and that one where the financially strapped protagonist (who due to financial setbacks can no longer afford longevity drugs) tricks the bad guys into burning stage tree logs you pretty much get all of them plus Dr Pat’s addition. Not that most of these have not been reinforced by other authors.

  5. Rich is relative, especially if you have rich relatives but ya, here’s a like because I realize E doesn’t cover it and I don’t expect subsistence farmers in Sudan will be anywhere near the early adopters.

  6. Rich is relative especially if you have rich relatives but ya here’s a like because I realize E doesn’t cover it and I don’t expect subsistence farmers in Sudan will be anywhere near the early adopters.

  7. first guy I see that might actually be on to something. he’s almost 51 but looks at least a decade younger…

  8. first guy I see that might actually be on to something. he’s almost 51 but looks at least a decade younger…

  9. I don’t know; You know what engineers do once they get financially independent? That’s right: They work on what THEY find interesting. The thing is, it takes a long while for an engineer to reach that point most of the time, and by then they’re getting a bit slow, and don’t have a lot of energy. In a world where engineers lived a lot longer, and didn’t decline so much, you’d have a lot of independent engineers working on odd projects, or collaborating on interesting things. You know those consumer 3d printers? They came from such a collaboration…

  10. I don’t know; You know what engineers do once they get financially independent? That’s right: They work on what THEY find interesting.The thing is it takes a long while for an engineer to reach that point most of the time and by then they’re getting a bit slow and don’t have a lot of energy.In a world where engineers lived a lot longer and didn’t decline so much you’d have a lot of independent engineers working on odd projects or collaborating on interesting things.You know those consumer 3d printers? They came from such a collaboration…

  11. Here’s a like. Ya, when you combine Ethics of Madness and Grendel, both by Niven, and that one where the financially strapped protagonist (who, due to financial setbacks can no longer afford longevity drugs) tricks the bad guys into burning stage tree logs, you pretty much get all of them plus Dr Pat’s addition. Not that most of these have not been reinforced by other authors.

  12. Here’s a like. Ya when you combine Ethics of Madness and Grendel both by Niven and that one where the financially strapped protagonist (who due to financial setbacks can no longer afford longevity drugs) tricks the bad guys into burning stage tree logs you pretty much get all of them plus Dr Pat’s addition. Not that most of these have not been reinforced by other authors.

  13. Rich is relative, especially if you have rich relatives but ya, here’s a like because I realize E doesn’t cover it and I don’t expect subsistence farmers in Sudan will be anywhere near the early adopters.

  14. Rich is relative especially if you have rich relatives but ya here’s a like because I realize E doesn’t cover it and I don’t expect subsistence farmers in Sudan will be anywhere near the early adopters.

  15. I don’t know; You know what engineers do once they get financially independent? That’s right: They work on what THEY find interesting.

    The thing is, it takes a long while for an engineer to reach that point most of the time, and by then they’re getting a bit slow, and don’t have a lot of energy.

    In a world where engineers lived a lot longer, and didn’t decline so much, you’d have a lot of independent engineers working on odd projects, or collaborating on interesting things.

    You know those consumer 3d printers? They came from such a collaboration…

  16. Here’s a like. Ya, when you combine Ethics of Madness and Grendel, both by Niven, and that one where the financially strapped protagonist (who, due to financial setbacks can no longer afford longevity drugs) tricks the bad guys into burning stage tree logs, you pretty much get all of them plus Dr Pat’s addition. Not that most of these have not been reinforced by other authors.

  17. Rich is relative, especially if you have rich relatives but ya, here’s a like because I realize E doesn’t cover it and I don’t expect subsistence farmers in Sudan will be anywhere near the early adopters.

  18. first guy I see that might actually be on to something. he’s almost 51 but looks at least a decade younger…

  19. first guy I see that might actually be on to something. he’s almost 51 but looks at least a decade younger…

  20. I may then return to my former profession. In that life I was a Theoretical physicist. At the moment I’m in charge of an army latrine.

  21. I may then return to my former profession. In that life I was a Theoretical physicist. At the moment I’m in charge of an army latrine.

  22. I may then return to my former profession. In that life I was a Theoretical physicist. At the moment I’m in charge of an army latrine.

  23. I may then return to my former profession. In that life I was a Theoretical physicist. At the moment I’m in charge of an army latrine.

  24. If they were genuinely senescent, they couldn’t be contributing to your capacity to think anyway. We do need a way to rescue senescent cells in the brain, though. I suspect most of the time it’s due to being taken over by mutant mitochondria that don’t produce energy, so the cell is just barely getting by on fermentation. Mitochondria are part of the apotosis system anyway, so you kind of expect senescent cells to have bad mitochondria.

  25. If they were genuinely senescent they couldn’t be contributing to your capacity to think anyway. We do need a way to rescue senescent cells in the brain though. I suspect most of the time it’s due to being taken over by mutant mitochondria that don’t produce energy so the cell is just barely getting by on fermentation. Mitochondria are part of the apotosis system anyway so you kind of expect senescent cells to have bad mitochondria.

  26. If they were genuinely senescent, they couldn’t be contributing to your capacity to think anyway. We do need a way to rescue senescent cells in the brain, though. I suspect most of the time it’s due to being taken over by mutant mitochondria that don’t produce energy, so the cell is just barely getting by on fermentation. Mitochondria are part of the apotosis system anyway, so you kind of expect senescent cells to have bad mitochondria.

  27. If they were genuinely senescent they couldn’t be contributing to your capacity to think anyway. We do need a way to rescue senescent cells in the brain though. I suspect most of the time it’s due to being taken over by mutant mitochondria that don’t produce energy so the cell is just barely getting by on fermentation. Mitochondria are part of the apotosis system anyway so you kind of expect senescent cells to have bad mitochondria.

  28. Let’s remember that the very reason institutes such as the Buck are creating outlets like Unity is for the express purpose of making these new classes of drugs widely available. And this is precisely what governments in developed nations want. At first they told us (and particularly women) that you could have careers; make lots of money; avoid being tied down spouses and kids. Tens of millions bought into this selfish madness, and now all the demographic models show the horror of this insane paradigm. Populations in developed nations are not even reproducing at replacement levels. They are in negative trends which will eventually result in disaster. 1 in 5 people in Japan are over 70 and living alone. China is facing a retirement avalanche in a few years. It’s worse yet in many western nations. America is showing some signs of reversing the trend in favor of the family, but most of the developed nations have opted towards making their populations work longer – as opposed to supporting and encouraging large families. We should all pray for both: A return to the paradigm of large families where people can feel secure and grounded – and a greatly improved healthspan which will bolster economics and maintain the tax base. Therefore: Live Long, Reproduce, and Prosper !!!

  29. Let’s remember that the very reason institutes such as the Buck are creating outlets like Unity is for the express purpose of making these new classes of drugs widely available. And this is precisely what governments in developed nations want. At first they told us (and particularly women) that you could have careers; make lots of money; avoid being tied down spouses and kids. Tens of millions bought into this selfish madness and now all the demographic models show the horror of this insane paradigm. Populations in developed nations are not even reproducing at replacement levels. They are in negative trends which will eventually result in disaster.1 in 5 people in Japan are over 70 and living alone. China is facing a retirement avalanche in a few years. It’s worse yet in many western nations. America is showing some signs of reversing the trend in favor of the family but most of the developed nations have opted towards making their populations work longer – as opposed to supporting and encouraging large families.We should all pray for both: A return to the paradigm of large families where people can feel secure and grounded – and a greatly improved healthspan which will bolster economics and maintain the tax base.Therefore: Live Long Reproduce and Prosper !!!

  30. Let’s remember that the very reason institutes such as the Buck are creating outlets like Unity is for the express purpose of making these new classes of drugs widely available. And this is precisely what governments in developed nations want. At first they told us (and particularly women) that you could have careers; make lots of money; avoid being tied down spouses and kids. Tens of millions bought into this selfish madness, and now all the demographic models show the horror of this insane paradigm. Populations in developed nations are not even reproducing at replacement levels. They are in negative trends which will eventually result in disaster. 1 in 5 people in Japan are over 70 and living alone. China is facing a retirement avalanche in a few years. It’s worse yet in many western nations. America is showing some signs of reversing the trend in favor of the family, but most of the developed nations have opted towards making their populations work longer – as opposed to supporting and encouraging large families. We should all pray for both: A return to the paradigm of large families where people can feel secure and grounded – and a greatly improved healthspan which will bolster economics and maintain the tax base. Therefore: Live Long, Reproduce, and Prosper !!!

  31. Let’s remember that the very reason institutes such as the Buck are creating outlets like Unity is for the express purpose of making these new classes of drugs widely available. And this is precisely what governments in developed nations want. At first they told us (and particularly women) that you could have careers; make lots of money; avoid being tied down spouses and kids. Tens of millions bought into this selfish madness and now all the demographic models show the horror of this insane paradigm. Populations in developed nations are not even reproducing at replacement levels. They are in negative trends which will eventually result in disaster.1 in 5 people in Japan are over 70 and living alone. China is facing a retirement avalanche in a few years. It’s worse yet in many western nations. America is showing some signs of reversing the trend in favor of the family but most of the developed nations have opted towards making their populations work longer – as opposed to supporting and encouraging large families.We should all pray for both: A return to the paradigm of large families where people can feel secure and grounded – and a greatly improved healthspan which will bolster economics and maintain the tax base.Therefore: Live Long Reproduce and Prosper !!!

  32. Meh, even 3rd-world countries like India are able to mass-produce plenty of important pharmaceuticals on the cheap, and have been doing so for a long time. If this drug is identified as something important enough, then it can be mass-produced very cheaply, and govts will subsidize its production. So there don’t have to be haves and have-nots. But the demographic effect could be a problem, if you have lots of very elderly people continuing to live on while requiring lots of assistance, and yet not being as productive. What about reduced upward mobility, as the elderly continue to hog their upper echelon positions, preventing others from moving up?

  33. Meh even 3rd-world countries like India are able to mass-produce plenty of important pharmaceuticals on the cheap and have been doing so for a long time. If this drug is identified as something important enough then it can be mass-produced very cheaply and govts will subsidize its production. So there don’t have to be haves and have-nots. But the demographic effect could be a problem if you have lots of very elderly people continuing to live on while requiring lots of assistance and yet not being as productive. What about reduced upward mobility as the elderly continue to hog their upper echelon positions preventing others from moving up?

  34. Meh, even 3rd-world countries like India are able to mass-produce plenty of important pharmaceuticals on the cheap, and have been doing so for a long time. If this drug is identified as something important enough, then it can be mass-produced very cheaply, and govts will subsidize its production. So there don’t have to be haves and have-nots. But the demographic effect could be a problem, if you have lots of very elderly people continuing to live on while requiring lots of assistance, and yet not being as productive. What about reduced upward mobility, as the elderly continue to hog their upper echelon positions, preventing others from moving up?

  35. Meh even 3rd-world countries like India are able to mass-produce plenty of important pharmaceuticals on the cheap and have been doing so for a long time. If this drug is identified as something important enough then it can be mass-produced very cheaply and govts will subsidize its production. So there don’t have to be haves and have-nots. But the demographic effect could be a problem if you have lots of very elderly people continuing to live on while requiring lots of assistance and yet not being as productive. What about reduced upward mobility as the elderly continue to hog their upper echelon positions preventing others from moving up?

  36. Sociologically. That may affect retirement age. Insurance – both life, health. Have / have-not nations AND people groups. College professors tenure, politicians arguements, and other daily activities would change. If takes 100 years to get to an inhabitable planet, it’s much more doable. Overpopulation? No. IQ and politically correct tested get long lives, rest of planet “lessers people” ages, dies “early” on normal schedule. That means you, not me. Changes coming. Soon.

  37. Sociologically. That may affect retirement age. Insurance – both life health. Have / have-not nations AND people groups. College professors tenure politicians arguements and other daily activities would change. If takes 100 years to get to an inhabitable planet it’s much more doable. Overpopulation? No. IQ and politically correct tested get long lives rest of planet lessers people”” ages”””” dies “”””early”””” on normal schedule. That means you”””” not me. Changes coming. Soon.”””

  38. Sociologically. That may affect retirement age. Insurance – both life, health. Have / have-not nations AND people groups. College professors tenure, politicians arguements, and other daily activities would change. If takes 100 years to get to an inhabitable planet, it’s much more doable. Overpopulation? No. IQ and politically correct tested get long lives, rest of planet “lessers people” ages, dies “early” on normal schedule. That means you, not me. Changes coming. Soon.

  39. Sociologically. That may affect retirement age. Insurance – both life health. Have / have-not nations AND people groups. College professors tenure politicians arguements and other daily activities would change. If takes 100 years to get to an inhabitable planet it’s much more doable. Overpopulation? No. IQ and politically correct tested get long lives rest of planet lessers people”” ages”””” dies “”””early”””” on normal schedule. That means you”””” not me. Changes coming. Soon.”””

  40. Experienced minds in youthful bodies would be interesting. Some authors have theorized that you would be able to pick out the old ones easily as they would be (pick one) A) Apathetic, B) Unnaturally calm, C) Somewhat senile or overly set in their ways, D) Extremely graceful (capable of minimal effort movements at high speed, never hitting their funny bones or skinning a knee), E) Exuding confidence (or entitlement, take your pick).

  41. Experienced minds in youthful bodies would be interesting.Some authors have theorized that you would be able to pick out the old ones easily as they would be (pick one) A) Apathetic B) Unnaturally calm C) Somewhat senile or overly set in their ways D) Extremely graceful (capable of minimal effort movements at high speed never hitting their funny bones or skinning a knee) E) Exuding confidence (or entitlement take your pick).

  42. Experienced minds in youthful bodies would be interesting. Some authors have theorized that you would be able to pick out the old ones easily as they would be (pick one) A) Apathetic, B) Unnaturally calm, C) Somewhat senile or overly set in their ways, D) Extremely graceful (capable of minimal effort movements at high speed, never hitting their funny bones or skinning a knee), E) Exuding confidence (or entitlement, take your pick).

  43. Experienced minds in youthful bodies would be interesting.Some authors have theorized that you would be able to pick out the old ones easily as they would be (pick one) A) Apathetic B) Unnaturally calm C) Somewhat senile or overly set in their ways D) Extremely graceful (capable of minimal effort movements at high speed never hitting their funny bones or skinning a knee) E) Exuding confidence (or entitlement take your pick).

  44. Up to 50% of brain cells are senescent in elderly people. It would be difficult to appreciate improvement of overall health, if half of your brain is gone.

  45. Up to 50{22800fc54956079738b58e74e4dcd846757aa319aad70fcf90c97a58f3119a12} of brain cells are senescent in elderly people. It would be difficult to appreciate improvement of overall health if half of your brain is gone.

  46. Up to 50% of brain cells are senescent in elderly people. It would be difficult to appreciate improvement of overall health, if half of your brain is gone.

  47. Up to 50{22800fc54956079738b58e74e4dcd846757aa319aad70fcf90c97a58f3119a12} of brain cells are senescent in elderly people. It would be difficult to appreciate improvement of overall health if half of your brain is gone.

  48. The real question is whether it rejuvenates, or just slows aging. I suspect a mix. But good point about getting “off label” access once it’s approved for some disease. I could probably swing that, I’ve got a good relationship with my doctor.

  49. The real question is whether it rejuvenates or just slows aging. I suspect a mix.But good point about getting off label”” access once it’s approved for some disease. I could probably swing that”””” I’ve got a good relationship with my doctor.”””

  50. The real question is whether it rejuvenates, or just slows aging. I suspect a mix. But good point about getting “off label” access once it’s approved for some disease. I could probably swing that, I’ve got a good relationship with my doctor.

  51. The real question is whether it rejuvenates or just slows aging. I suspect a mix.But good point about getting off label”” access once it’s approved for some disease. I could probably swing that”””” I’ve got a good relationship with my doctor.”””

  52. If they were genuinely senescent, they couldn’t be contributing to your capacity to think anyway. We do need a way to rescue senescent cells in the brain, though. I suspect most of the time it’s due to being taken over by mutant mitochondria that don’t produce energy, so the cell is just barely getting by on fermentation. Mitochondria are part of the apotosis system anyway, so you kind of expect senescent cells to have bad mitochondria.

  53. Let’s remember that the very reason institutes such as the Buck are creating outlets like Unity is for the express purpose of making these new classes of drugs widely available. And this is precisely what governments in developed nations want.

    At first they told us (and particularly women) that you could have careers; make lots of money; avoid being tied down spouses and kids. Tens of millions bought into this selfish madness, and now all the demographic models show the horror of this insane paradigm. Populations in developed nations are not even reproducing at replacement levels. They are in negative trends which will eventually result in disaster.

    1 in 5 people in Japan are over 70 and living alone. China is facing a retirement avalanche in a few years. It’s worse yet in many western nations. America is showing some signs of reversing the trend in favor of the family, but most of the developed nations have opted towards making their populations work longer – as opposed to supporting and encouraging large families.

    We should all pray for both: A return to the paradigm of large families where people can feel secure and grounded – and a greatly improved healthspan which will bolster economics and maintain the tax base.

    Therefore: Live Long, Reproduce, and Prosper !!!

  54. Meh, even 3rd-world countries like India are able to mass-produce plenty of important pharmaceuticals on the cheap, and have been doing so for a long time. If this drug is identified as something important enough, then it can be mass-produced very cheaply, and govts will subsidize its production. So there don’t have to be haves and have-nots. But the demographic effect could be a problem, if you have lots of very elderly people continuing to live on while requiring lots of assistance, and yet not being as productive. What about reduced upward mobility, as the elderly continue to hog their upper echelon positions, preventing others from moving up?

  55. Sociologically. That may affect retirement age. Insurance – both life, health. Have / have-not nations AND people groups. College professors tenure, politicians arguements, and other daily activities would change. If takes 100 years to get to an inhabitable planet, it’s much more doable.
    Overpopulation? No. IQ and politically correct tested get long lives, rest of planet “lessers people” ages, dies “early” on normal schedule. That means you, not me. Changes coming. Soon.

  56. Experienced minds in youthful bodies would be interesting.

    Some authors have theorized that you would be able to pick out the old ones easily as they would be (pick one) A) Apathetic, B) Unnaturally calm, C) Somewhat senile or overly set in their ways, D) Extremely graceful (capable of minimal effort movements at high speed, never hitting their funny bones or skinning a knee), E) Exuding confidence (or entitlement, take your pick).

  57. Well, you’ve heard the guy – rejuvenation technology in 50 years, just when he will need it! That’s how it always is with these tech guys. Once senolitics get approved for individual diseases, you will be able to get them from a cooperative doctor, for a price. I think this is the most realistic prospect right now.

  58. Well you’ve heard the guy – rejuvenation technology in 50 years just when he will need it! That’s how it always is with these tech guys.Once senolitics get approved for individual diseases you will be able to get them from a cooperative doctor for a price. I think this is the most realistic prospect right now.

  59. Well, you’ve heard the guy – rejuvenation technology in 50 years, just when he will need it! That’s how it always is with these tech guys. Once senolitics get approved for individual diseases, you will be able to get them from a cooperative doctor, for a price. I think this is the most realistic prospect right now.

  60. Well you’ve heard the guy – rejuvenation technology in 50 years just when he will need it! That’s how it always is with these tech guys.Once senolitics get approved for individual diseases you will be able to get them from a cooperative doctor for a price. I think this is the most realistic prospect right now.

  61. Up to 50% of brain cells are senescent in elderly people. It would be difficult to appreciate improvement of overall health, if half of your brain is gone.

  62. Thing is, they are likely to make 75 a lot like 55, and do it for long enough you can see it become more like 45, or even 35.

  63. Thing is they are likely to make 75 a lot like 55 and do it for long enough you can see it become more like 45 or even 35.

  64. Thing is, they are likely to make 75 a lot like 55, and do it for long enough you can see it become more like 45, or even 35.

  65. Thing is they are likely to make 75 a lot like 55 and do it for long enough you can see it become more like 45 or even 35.

  66. The real question is whether it rejuvenates, or just slows aging. I suspect a mix.

    But good point about getting “off label” access once it’s approved for some disease. I could probably swing that, I’ve got a good relationship with my doctor.

  67. Well, you’ve heard the guy – rejuvenation technology in 50 years, just when he will need it! That’s how it always is with these tech guys.

    Once senolitics get approved for individual diseases, you will be able to get them from a cooperative doctor, for a price. I think this is the most realistic prospect right now.

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