How Many Will Go For the New Antiaging Options?

For at least the next, ten to fifteen years, people who want to apply lifestyle and medicine to apply the latest research in antiaging it will mostly be do-it-yourself. People will have to seek out open-minded doctors if they need certain prescriptions. There will also be options in terms of overseas pharmacies and clinics. Clearly, these options can have some more risks than working within the medical system. However, people have already used these alternative options for lower cost access to drugs like Viagra and Cialis.

How Many Will Go For the New Antiaging Options? Perhaps 1% have gone for comprehensive diet and exercise lifestyles that can add 7 years to lifespan. About 80% of the world does not smoke. About 85% of the US population does not smoke. 70% of the world is not obese.

The number of people following and sustaining the calorie restriction diet is perhaps only a few tens of thousands. There are far more trying the various forms of intermittent fasting.

There are some early antiaging drugs and supplements which seem to have some scientific evidence of some effectiveness. Those are metformin, NAD+ and other drugs.

Some studies indicate that metformin is half as effective as aggressive lifestyle management.

Lifestyle Modification

There are various diet and lifestyle modifications which can enable people to have a 1 in 2 chance to live to about 88 instead of 80 for men or 83 for women.

There a few million people who follow the Seventh-day Adventist lifestyle. There are other populations and lifestyles like the Okinawa diet.

There were a few roughly 30,000 person Seven-day Adventist participated in few health studies.

On average Adventist men live 7.3 years longer and Adventist women live 4.4 years longer than other Californians.

Five simple health behaviors promoted by the Seventh-day Adventist Church for more than 100 years (not smoking, eating a plant-based diet, eating nuts several times per week, regular exercise and maintaining normal body weight) increase life span up to 10 years.

* Reducing consumption of red and white meat was associated with a decrease of colon cancer.
* Eating legumes was protective for colon cancer.
* Eating nuts several times a week reduces the risk of heart attack by up to 50%.
* Eating whole bread instead of white bread reduced non-fatal heart attack risk by 45%.
* Drinking 5 or more glasses of water a day may reduce heart disease by 50%.
* Men who had a high consumption of tomatoes reduced their risk of prostate cancer by 40%.
* Drinking soy milk more than once daily may reduce prostate cancer by 70%.

Calorie Restriction Lifespan Impact

In Nature Communications in 2017 there was a study that looked at the survival of Monkeys using calorie restriction.

The median survival estimates for old-onset males were very high, similar to what has been reported previously as the 90th percentile for this species (∼35 years of age). Six of the original 20 monkeys have lived beyond 40 years of age, the previous maximal lifespan recorded, and one old-onset CR male monkey is currently 43 years old, which is a longevity record for this species. Median survival estimates for old-onset females, ∼27 and ∼28 for controls and CR respectively, were also greater than national median lifespan estimates, with one remaining female currently 38 years of age. The clear benefit in survival estimates for monkeys within the old-onset cohort compared to UW controls suggests that food intake can and does influence survival.

If humans had a similar impact from calorie restriction then instead 50% of the people making it to 80 then it would be 50% making it to 89. Currently, 10% made it to 89 or higher.

Senolytics Drugs to Remove Senescent Cells

Senolytics Drugs extend the lifespan of mice by about 35% and newer drug protocols might achieve a 50% increase in mice lifespan.

In an interview in 2016, Nathaniel David (CEO, Unity Biotechnology indicated that he thought that the Unity Senolytic drugs would be approved for commercial usage around 2023. He indicated the clinical trials would start at about 2018 and he was right.

Nathaniel feels that the various localized versions of senolytics would eventually give confidence to the FDA that eliminating senescent cells throughout the body would be safe and effective and that this could be achieved in the 2030s.

Nathaniel feels that Senolytics by themselves would improve healthspan and reduce age-related diseases in humans.

For those who cannot wait up to fifteen years for commercial available of all-body senolytics, then the current option is to get Dasatinib-Quercetin drugs to remove senescent cells.

Dasatinib is a chemotherapy drug. It is used in combination with Quercetin, a plant flavonol to extend life. Taken together in clinical trials, the drug cocktail was shown to extend the life of lab mice by 36 percent. The effect seems to have the same amount of antiaging as calorie restriction.

AgeX Inducing Regeneration and Other Stem Cell Work

Nextbigfuture has had recent interviews with Dr. Michael West and Aubrey de Grey of AgeX.

AgeX is looking to apply stem cells and gene therapy-induced and telomerase tissue regeneration for antiaging.

There are two main areas of AgeX work.
1. Purestem. It creates highly pure populations of particular types of stem cells. You need to not use pluripotent stem cells inside the body. You need to slightly differentiate the stem cells but make them oligopotent. They can become a particular type of stem cell. AgeX technology can produce this reliably and with high purity.

2. iTr. AgeX is working on induced tissue regeneration (or rejuvenation). AgeX has identified genes to make them regenerative but do not make them pluripotent.

Other researchers are making progress preventing stem cells and tissue transplants from triggering immune system response. They are also making progress to universal stem cells that would enable mass produced stem cell treatments. If these advances are made the cost for stem cell treatments would be far lower and they would be more effective. There would not be the costs, risks and downsides of drugs to knock down the immune system to prevent rejection.

Gene Therapy for Aging Reversal

George Church revealed progress on aging reversal using gene therapies. They have delivered 45 gene therapies to provide aging reversal. They find the combined treatment is effective against obesity, diabetes, osteoarthritis, cardiac damage and kidney disease.

The peer-reviewed paper on the age-reversing combination gene therapy should be published this year. There has been the rumor that the existing age-reversing combination gene therapy extended the lifespan of mice by 100%. This would be triple the effect of calorie restriction. If it was successfully applied to humans and had the same

At 32:00-33:30 minutes George Church specifically describes delivering 45 age-reversing gene therapies to treat multiple age-related diseases.

This is the work that Nextbigfuture has been expecting from George’s company Rejuvenate Bio.

Rejuvenate Bio has been using the aging reversal therapies on dogs for almost all of 2018.

George Church expects to get the treatment to people around 2025.

George gave eight examples of aging reversal that have been published and reported by various researchers. Some researchers have used small molecules and others used other methods.

He wanted to show that these are real treatments that dramatically reverse aging damage.

Effective treatment and reversal of obesity, diabetes, cardiac, arthritis and kidney damage could boost the lifespan of many people and make 95-year life expectancy possible. Fixing all aging damage would put us toward a path of extreme longevity.

SOURCES- Unity Biotech, SENS, Bill Faloon, George Church, AgeX, Interviews with Aubrey de Grey and Michael West

Written By Brian Wang.