Intellia Fixed 95-98% T-Cells Inside the Body Using CRISPR Gene Therapy

Intellia and its research collaborator, IRCCS Ospedale San Raffaele presented new in vitro data showing that CRISPR/Cas9 editing resulted in over 98% knockout of the endogenous T cell receptor (TCR), while achieving transfer of various Wilms’ Tumor 1 (WT1)-specific TCRs into over 95% of isolated T cells.

Intellia Therapeutics is a leading genome editing company focused on developing curative therapeutics using the CRISPR/Cas9 system. Intellia believes the CRISPR/Cas9 technology has the potential to transform medicine by permanently editing disease-associated genes in the human body with a single treatment course, and through improved cell therapies that can treat cancer and immunological diseases, or can replace patients’ diseased cells.

SOURCES- Intellia
Written By Brian Wang.

18 thoughts on “Intellia Fixed 95-98% T-Cells Inside the Body Using CRISPR Gene Therapy”

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  8. Will this repairing of T-Cells then result in a fixing of autoimmune and inflammation problems that occur in the bodies of elderly people? What are the follow-on benefits of the better T-Cells?

  9. In the near future it will extend to all cells. Research on Genetic engineering is speeding up rapidly. They have begun doing genetic engineering on pet dogs for certain diseases(heart). It takes 1 year for the FDA to authorize/approve a therapy/drug for dogs. If they find a cure for dogs, for (let’s say) all cancer or diabetes etc that is 100% effective. A disease that kills a VERY great number of people a year, the FDA will be forced to FASTTRACK that treatment/drug for humans(with modifications for humans).
    This is not science fiction it is happening now at a accelerating rate.

  10. It says this was in vitro, using isolated cells, so I don’t think the headline should say “inside the body”. It looks like they were generating cells for immunotherapy. They do have other, in vivo stuff, but not this one.

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