Soft Cap Emitting Electromagnetic Waves has Reversed Memory Loss in Alzheimer’s patients

A bioengineered soft cap emitting electromagnetic waves has reversed memory impairment of Alzheimer’s patients (AD).

This is a patient wearing MemorEM. CREDIT NeuroEM Therapeutics, Inc.

Alzheimer’s Disease (AD) is disease of brain aging that causes progressive, severe memory loss. There is no effective “drug” to prevent or treat AD and most believe that it is unlikely that any will be developed in the near future. Therefore, other therapeutic interventions are desperately needed.

NeuroEM Therapeutics has developed a first-in-class, self-contained head device (the MemorEM™) to treat AD with electromagnetic waves – a therapy that they have pioneered and tested successfully in AD animal studies with no adverse events seen. Our novel, proprietary technology appears to directly affect the AD process to prevent and reverse memory impairment. The MemorEM head device, which allows for complete mobility during one-hour treatments “in home”, has been successfully used in NeuroEM’s just-completed Open-Label clinical trial that evaluated the safety and efficacy of Transcranial Electromagnetic Treatment (TEMT) in Alzheimer’s patients. In view of its promising effects on memory in this clinical trial, TEMT could be an entirely new bioengineering-based intervention against AD.

The investigators had previously demonstrated that treating AD mice with electromagnetic waves in the radiofrequency range resulted in protection against memory impairment in young AD mice and reversal of memory impairment in aged AD mice.

For the present clinical study in humans, the investigators used the same treatment (twice daily for 1-hour) through creation of NeuroEM’s first-in-class MemorEMTM head device. The device has multiple, highly-specialized emitters positioned within a head cap that are activated sequentially, with treatments easily administered in-home by the patient’s caregiver. As well, the device allows for near complete mobility to perform nearly all household activities during treatments.

Results demonstrate that TEMT was safe in all eight participating patients with mild to moderate AD and enhanced cognitive performance in seven of them, as measured by their ADAS-cog score, which is the benchmark for testing AD therapeutics.

The investigators indicated they have strong evidence that TEMT is directly affecting the Alzheimer’s disease process by easily penetrating the brain and brain cells to break up aggregates of two toxic proteins inside brain cells called A-beta and tau.

TEMT’s ability to disaggregate both toxic proteins inside brain cells (neurons) appears to be key to stopping and reversing the cognitive loss of AD. Present AD drugs in clinical trials have great difficulty getting into the brain and then into brain cells. Even if they succeeded in doing so, they do not yet have the capacity to target the small aggregates of A-beta and tau proteins that appear to be causative to AD.

NeuroEM Therapeutics is planning for a pivotal clinical trial to begin recruitment of approximately 150 mild/moderate AD subjects later this year for treatment with the company’s MemorEMTM device. If that trial shows continued safety and cognitive benefits, NeuroEM Therapeutics plans to ask the FDA for approval of the MemorEM device for treatment of AD. The clinical locations for this multi-site trial have not yet been determined.

Journal of Alzheimer’s Disease – A Clinical Trial of Transcranial Electromagnetic Treatment in Alzheimer’s Disease: Cognitive Enhancement and Associated Changes in Cerebrospinal Fluid, Blood, and Brain Imaging

22 thoughts on “Soft Cap Emitting Electromagnetic Waves has Reversed Memory Loss in Alzheimer’s patients”

  1. True, if you read the reports they spend more time talking about the safety and lack of side effects than the actual good treatment results.

    This was a Phase 1 trial.

    We do need to show Phase 1 for medical devices, or at least the ones that aren’t obviously safe “by design”. Which included the ones that I worked on.

    This would probably be more stringent that our examples, because they claim their machine causes direct biochemical changes. Medical approval authorities would regard what is clearly a blunt instrument that causes biochem changes in the brain to be something where nothing gets by on mere analysis.

    “Yeah, so basically we stick the patient’s head in a microwave oven until the proteins start to change and hope that the changes are all good.” That’s going to need a LOT of safety data.

  2. Yes, my question is what the mechanism is for the energy of the radio waves ending up selectively in these aggregates. Microwaves in microwave ovens work by wiggling the dipoles of the water molecules, but I doubt these tangles are significantly polarized.

    I suppose it might be individual prions being wiggled, and the bonding between them is just so puny that it breaks up the tangles even at low power levels.

  3. There are still bonds in aggregates of proteins but not covalent bonds. Few ionic bonds either. There are hydrogen bonds and Van der Waals forces involved though. These are much weaker and likely why the aggregates can be disassembled with little effects on normal proteins. Breaking up the aggregates allows for easier access for the cellular machinery used to either fix or degrade improperly folded/denatured proteins. Could be the mechanism here.

  4. Sounds like a Phase 1a trial. Which is mostly to determine safety. Efficacy is usually not a primary endpoint, though it can be a secondary endpoint. A Phase 1a trial is usually quite small. Normally a Phase 1b would be next to determine safe dosing before starting a Phase 2 trial for efficacy. Probably unnecessary for a device though. I’m less familiar with that process.

  5. If they turned up the power it would be like a microwave oven and it would surely denature the proteins. MICROWAVES operate at 2.5 GHz near what they are beaming into people’s heads- 1.0 GHz

  6. How does the EM radiation affect the oligomers? What does it do to make the tau protein tangles dissolve?

  7. Electrifying people’s heads seems to be an up-and-coming thing these days:

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  8. Might be real, but it reminds me so much of the early days of electricity popularization, when magical thinking generated all sorts of weird electrical ‘therapy’ devices.

    I guess I’d be more convinced if there were an explanation of why the researchers made these caps – why they hypothesized before hand that EM waves would ‘disentangle’ protein aggregates. Did they design the EM radiation sequences to be ‘tuned’ to heat those proteins? To induce static electric fields in the aggregates that push them apart? Or what exactly did they think they were doing?

  9. Aggregation is just like a tangle of fuzz or bundle of spaghetti – there are no bonds. The energy absorbed is just helping to disentangle them.

  10. If the EM waves are breaking covalent, ionic or any type of peptide bond in a denatured protein they are definitely affecting the healthy proteins. Denatured protein usually have tighter bonds that healthy proteins b/c of chemical cross-linking e.g. as seen in AGE formation during diabetes or increasing age

  11. Yes, this was 8 patients, not blinded, in a disease that is notoriously hard to get a handle on.

    A great start, but only a start.

  12. I find it dubious on the basis that long wave radiation typically will not be absorbed by structures of molecular scale, but rather simply induces large scale currents. It would be Nobel Prize material if they’d gotten a structure as small as a prion tangle to interact selectively with radio waves.

    OTOH, there is this from their article: “TEMT also produced increases in cerebrospinal fluid (CSF) levels of soluble Aβ1-40 and Aβ1-42, cognition-related changes in CSF oligomeric Aβ, a decreased CSF p-tau/Aβ1-42 ratio, and reduced levels of oligomeric Aβ in plasma.”

    These would be objectively measurable biochemical signals, so unless this is outright fraud, it’s accomplishing SOMETHING.

    The other alternative, I suppose, is that it’s either an electrochemical effect, (Long range currents!) or a thermal effect. At 1W/kg, either is at least somewhat plausible.

  13. It would do it to both. That wouldn’t be harmful though – you’re probably thinking of protein denaturation which would be.

  14. It does beg the question … QUANTITATIVE measure of efficacy? On certainly needs to have a control group undergoing similar treatment with caps that have nothing more complicated in them than say film-noninductive heating pads instead of EM coils.  

    Sealed in the blue cap, no one will be the wiser. Then let the trials proceed.

    Just saying,
    GoatGuy ✓

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