Scientists joining Altos:
Juan Carlos Izpisúa Belmonte, a Spanish biologist at the Salk Institute, in La Jolla, California.Juan researched mixing human and monkey embryos and has predicted that human lifespans could be increased by 50 years.
Steve Horvath, a UCLA professor and developer of a “biological clock” that can accurately measure human aging.
Shinya Yamanaka, who shared a 2012 Nobel Prize for the discovery of reprogramming, will be an unpaid senior scientist and will chair the company’s scientific advisory board.
Altos is offering key hires sports-star salaries of $1 million a year or more, plus equity, as well as freedom from the hassle of applying for grants.
Manuel Serrano of the Institute for Research in Biomedicine, in Barcelona, Spain, said the company would pay him five to 10 times what he earns now.
Altos is aiming to understand rejuvenation.
SOURCES- Aubrey de Grey, Altos, Technology Review
Written by Brian Wang, Nextbigfuture.com
Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.
Known for identifying cutting edge technologies, he is currently a Co-Founder of a startup and fundraiser for high potential early-stage companies. He is the Head of Research for Allocations for deep technology investments and an Angel Investor at Space Angels.
A frequent speaker at corporations, he has been a TEDx speaker, a Singularity University speaker and guest at numerous interviews for radio and podcasts. He is open to public speaking and advising engagements.
Yeah, that's the paper/results I was thinking of.
Such a relatively simple and apparently safe treatment would seem worth getting into human trials ASAP.
Even if it just lets elderly people be somewhat healthier and feel better, that'd be worth doing.
Milkshake Duck strikes again
The joined old/young mouse "vampire" research guys originally thought NIAD/NAD+ related stuff was key (and it is important separately), but went back and looked at just raw filtering of broken proteins in old mouse blood to check their bases and got almost the same result. I think they ended up filtering like 50% or so of the proteins and backfilling with just saline and albumin and didn't see any notable negative side effects, and most of the positive ones from the earlier research, so the NIAD angle was a partial red herring. There's a similar filtering treatment already in use medically (TPE) for treating something else that could be tweaked to do this. I haven't seen much since this paper in major media sources though.
https://www.aging-us.com/article/103418
Could you please tell me how much quercetin do you take? And what results
did you observe on your skin?
If I can walk into a clinic in 15 years, plop down, say, a million for me and a million for my wife and they make us back into 19 year olds, I’m going to call that real results.
But I don’t expect to see those kind of results tomorrow, or even next week. Baby steps.
Some say variety is the spice of life. Maybe Aubrey was just alpha testing a different longevity technique? He did find the bug, and unfortunately, "consent" is the fly in the ointment
And there's so much commonality between rocket science and biotechnology, too!
OK, seriously, he does have that neural lace program going. Maybe he figures on being uploaded?
https://neuralink.com/
Hopefully SENS and by extension the longevity/life extension movement has reached a point where we don't need him anymore; unfortunate circumstance but what can you do?
Well, that's sad. Feet of clay, I guess. At least he can shave off that beard, now, and nobody will recognize him.
No; thanks just now heard of it:
Anti-aging research group the SENS Research Foundation has fired chief
science officer Aubrey de Grey, who was accused of sexual harassment by
two women earlier this month.
https://www.fiercebiotech.com/biotech/anti-aging-foundation-sens-turfs-de-grey-after-allegations-he-interfered-investigation-into
Did anyone mention how Aubrey de Grey just got fired from SENS?
Several new Ferraris and yatchs.
Oh wait, you mean in antiaging therapies?
Not so far.
no.
The closest I can think of is Bioviva. But part of the problem is that even the safe haven countries they do this stuff in don't like the bad publicity, so it never turns into a really decent large scale trial. So we never really prove efficacy, just lots of small quiet "it might work" kind of things.
Easier to scam the wealthy then run a decent clinical trial on them. I'm sure the Caymans have lots of stem cell treatments available.
Musk needs to take aging on. He is definitely visionary and also he is aging.
I think these guys are taking a logical approach in a way. Can cells be reprogrammed in a Petri dish to be younger? Yes they can. That is a true statement. So there is your moonshot.
Whether they actually pull it off though is another story. They could spend hundreds of millions of dollars, and years trying to reprogram human cells to do this in a human body, and they could get nowhere. But at least they know what they are specifically after.
I agree in the long run: Our biology is not designed for immortality, we'd need to be 'recompiled' from the bottom up.
But for any living human, the low hanging fruit offers the best chance of actually getting more years of life.
heard that a few of the major players/ contributors have already signed up for vitrification – like an Alcor Life Extension program for head and/or head/body storage for future revivial. Heard that you need to be dead when they take you in. Alternatively, I thought that periodic hibernation would be great – 1 year up, 5 years down — then watch the centuries move and develop…
many suggest medical tourism in international waters/ island equivalent (caymans for health?) as a way to minimize interference and maximize income from those wealthy individuals who crave privacy, a chance at 150, and to be part of the vanguard of new treatments… though I think even the WHO has pretty strict protocols throughout…
Of course they will 'cave' to government regulations. What do you expect them to do in dark mode? Murder people in unlicensed experiments?
If you want to see something truly interesting, it has to be under a different government that isn't afraid to back a minority position on medical ethics, and any companies involved couldn't be multinationals.
how would you even measure success in any kind of limited time frame? fruit flies living for a year? lab rats living to 10? localized success on an organ or limb or tissue? development of biological clocks which can fidn soem kind of 'deterioration metric' have been proposed – but they too would need to be vetted.
agreed. easier to have figured out a map than to undertake the journey. These people's big paths are certainly compelling with notable early successes. But early successes are localized without being necessarily pragmatically scalable: senescent cell clearance, thymus, mitochondrial repair… The most prominent: Senescent cell therapies depend on identifying prime locations and large-scale success in each of those areas — kind of like chasing tumors with cancer… to know you can do damage (early stages) is one thing but to do 'enough good' that you can win the battle.. and essentially the war throughout is entirely different. Stem cells were the promised path the large part of a decade ago, but early successes have met large-scale obstacles. Anti-aging is a huge leap for medicine as fusion is a huge leap from fission…
Not convinced that such a Lab can make any difference unless they have truly top notch techno-visionaries that can work in an environment of minimal restrictions and undertake huge leaps of risky biological genius – we're talking frankenstein. we're talking tony stark. we're talking doc Brown. We're talking dr. henry wu.
Calico had gobs of money and exceptional resources to access but they have caved under regulations, bureacracy, baby steps supported by established medical know-how. Bah. Minimize small animal/ mammal testing. Move out from under FDA/ EMA.
Go dark for 10 years.
The human body is a fundamentally fragile and death-embracing mechanism — never truly immortal after pubescence with its current wet-ware. We can slow the slide by accelerating the repair of existing and reinstatement of the 'used up' — but its always a slide downward that is only mitigated by the rate and quality of ther repairs, with the last part-decade being a cliff. If you spend half your time being fixed since 25, what is the point to living past 120 in a clinic? Would you live in a bubble to get an extra 50 years?
Parts have to be re-imagined, re-built, re-designed. Environments optimized. But at what point are you no longer human. Which frailties, sentimentalities, inconveniences do you sacrifice? fertility? another's human touch? general socialization? 16 hours of being awake per day? certain limbs and senses? some memory, processing or empathy. We are optimized for mediocrity/ compromise
Thus the dilution research. The question was, is the effect due to diluting bad stuff, supplementing good stuff, or some combination? Dilution is easy and cheap, adding blood factors less so.
Research has shown with rats that blood plasma exchange is a better option than the vampire approach. Any exchange with human plasma has many potential side effects.
I'm curious about that myself.
The latest life extension news I've heard is mouse research, where Quercetin and Dasatinib successfully prevented (But not reversed!) spinal disk degeneration.
The Quercetin I'm already taking, and it seems to have positive results, at least as far as skin is concerned, but I don't have access to Dasatinib.
Epigenetics. Nurture and other developmental influences can control gene *expression* by epigenetic mechanisms. Janov has been manipulating these changes by reversing them in Primal Therapy for decades, and reporting it. It is true! "Cancer and heart disease are not he major killers they are thought to be. Repression is." Janov ~ 1990.
What has been happening with that blood plasma dilution scheme of late?
Lots of it being pumped into anti-aging but are we seeing any real results?