My Antiaging Journey Gets Serious

I wrote in February, 2022 about the need to get hardcore about mitigating aging when you are 60 and over.

I, Brian Wang, am turning 57 in a few months and the US actuarial tables show that my risk of death each year is passing 1% per year in the next few years. By the time most of us are 70, the risk of death in each year will pass 2% per year. If we can take care of ourselves with exercise, proper diet, and supplements, we might be able to reduce the annual risk by 30-50%. A 50% reduction would mean that you can be a healthy 70-year-old with an annual risk of dying that is the same as someone who was 58 or 60. If you are really good and taking care of yourself maybe you can have a 75% reduction in annual death risk versus people of your actual age. This would mean you could 70 with the risk of someone who was 51. You could 80 with the risk of someone who was 59. You could be 90 with the risk of someone who was 77. Currently, everyone will hit the aging wall at 95+ where the risks go up to 40% per year. Maybe taking really good care of ourselves can drop that to 10-20% per year. However, a meaningful impact beyond 95 will likely require major scientific success reversing all 7 forms of aging damage.

Our risk of dying increases as we age and this is how insurance companies who sell life insurance view our risk. They do not consider that maybe some of us will live to 60s, 70s, 80s or 90s or beyond.

I am going to take the products at I will also take the NAD test to see what this aging biomarker says about my NAD levels. I wil take the supplements: Berberine, NMN, SIRT6 activator and Fisetin. Nextbigfuture followers can also go to Donotage.products and use the code NEXTBIGFUTURE for a discount.

Berberine is a Geroprotector which canb slow the aging process. It is in the same class as Metformin. Metformin can be difficult in the USA as you need to get unless a doctor prescribe for pre-diabetes or diabetes. There is Metformin available online from Indian and other foreign pharmacy sources.

NAD+ restoration is enhanced with NMN. NAD levels decrease as we age. Restoring NAD using NMN can improve health. NAD+ is a nucleotide found in all living cells that plays an important role in energy metabolism. Levels may decline markedly with age and restoring them to a youthful state using various oral precursors, transdermal patches or IVs is believed to have beneficial effects on health and longevity.

Fisetin is a first-generation way to reduce zombie cells in the body. Our bodies produce a lot of cells when we are young so any cells that have any problem are removed from the body. When we get older our bodies do not produce a lot of new cells so our body keeps dysfunctional cells which produce toxins. Our body thinks it is better to have a half-effective cell than no cell. This choice is not good for our health as it makes arthritis and other conditions worse.

First generation senolytics: Dasatinib, Quercetin, Fisetin, Piperloungime, Azithromycin

I also take Quercetin.

Intermittent dosing of first-generation senolytics leads to the elimination of senescent cells in humans and by doing so, has the potential to prevent, delay, or alleviate multiple age-related diseases and increase the healthy lifespan.

Fisetin is a flavonoid found in many types of fruits and vegetables that is readily available over the counter as a supplement. Used intermittently at high doses it is supposed to act as a senolytic agent to remove senescent cells presenting an easily accessible, inexpensive therapeutic option.

SIRT6 Activator helps Sirtuin 6. Sirtuin 6 commonly known as the longevity sirtuin, has many health benefits. SIRT6 enhances DNA double strand break repair under oxidative stress. Oxidative stress can damage all components of the cell, including DNA. SIRT6 recruits PARP1 to facilitate DNA repair. SIRT6 is instrumental for your energy as it increases the efficiency of ATP production. SIRT6 has been shown to be closely related to a number of metabolic pathways and genome maintenance, as well as telomere stability.

SIRT6 is neuroprotective, and patients with Alzheimers disease have low levels of SIRT6. The SIRT6 protein plays a key role in DNA repair, maintenance of genomic stability in cells and healthy ageing. Activating SIRT6 can provide broad tumor suppressant and health promoting benefits. Professor Gorbunova and her team are currently carrying out a study using Do Not Age’s SIRT6Activator® and full publication is due in November.

SIRT6 Activator dosage is about 4 capsules (1600 mg) per day before a meal.

Rough guide dosage guide is based upon body weight is below:
<60kg = 800mg per day 60-100kg = 1600mg per day 100kg> = 2400mg per day

Promising Rejuvenation Therapies per Forever Healthy


Existing compounds that slow our aging process to some extent or at least significantly lower our probability to suffer from age-related diseases.
DMAE & Centrophenoxine

Compensatory Treatments

Therapies that do not address the root causes of our aging process but rather compensate for the effects that it has on our body.
Male & female steroid hormone restoration
NAD+ restoration
Young plasma infusions
Young plasma exosomes
Immune support with dendritic & NK cells

US Actuarial Tables

NAD Test and Supplements

79 thoughts on “My Antiaging Journey Gets Serious”

  1. Well, the DHEA is easy to get, and the Metformin isn't terribly hard, but HGH is hardly over the counter. It's pretty locked down in the US, he had trouble getting it even for experimental purposes.

    I'm exploring substituting GABA for the HGH, but I'm going to need to find some way to get the results measured.

  2. Generally to somebody who needs it desperately that toxic is better than none.

    Sadly, I can't donate blood anymore, due to irrationality about a cancer that would have killed me mover a decade ago if it hadn't been completely eradicated. It's hard arranging for blood and plasma to be removed if they're not going to use it.

  3. You're a big fellow aren't you?

    I'm not so large, so it looks like I've got more month's supply than I thought. Not a problem.


  4. 15mg/kg.

    Quercetin has an extremely high toxic dose, orally; Basically it doesn't kill you until you're choking on it. (Essentially, due to poor absorption.) But, of course, that's for acute poisoning.

    Studies of daily administration show it can be safe at daily doses of 500-1000mg per day for several months. OTOH, there's some concern that higher doses than that on a regular basis can cause kidney damage.

    But there was also a study in cancer patients that went as high as 2g one time dose, that didn't find that side effect.

    I arrived at a reasonable dose of 3g once a month on the basis that the average weight of the patients in that study was significantly less than mine, and that no negative effects had been reported even for the lighter patients.

  5. There is another class of compounds with a goal worth considering… muscle preservation and development. I know of three candidates. If someone has others please reply with a link.

    1. Sestrin. This protein is considered a "work-out" compound produced by heavy physical activity naturally. Supplementing this can benefit those who can't handle high exercise due to age, illness, and/or injury. This might have application to preserving muscle in 0-g, especially for long-term residents of ISS.
    For further study try this article:

    2. MOTS-c. This hormone is actually produced by mitochondria and tends to decline with age. The goal here is to improve energy.
    For further study try this article:

    3. BAM-15. This is a mitochondria uncoupler that causes them to burn energy more rapidly. It is targeted at weight loss, especially for elders.
    For further study try this article:
    It's one thing to take regular supplements to fight aging and other diseases, but quite another to gain the ability to produce them within the body. People are already researching gut bacteria modification to create a treatment for Parkinson's disease. Insulin is another good target since that would cure Type 1 diabetes at a stroke. Aging is next.

  6. OK Brett, I just ordered enough to try something similar.

    Your 3g was how many mg/kg? And how did you arrive at that dose?

  7. I don’t think I want to live longer the way this would is headed. There was a book in 1980 called BREAKTHROUGHS had had me thinking that I could save my parents. My Mom had cancer when I was 3 and my Dad also in I’ll health. They died nearly two decades ago…my heart is skipping beats and I’m broke. I begin to yearn for the grave this Easter.

  8. I assume you mean .5g (500mg). I take ordinary niacin as well as NR, just not the niacinamide/nicotinamide. I break the 500mg pills into 3 pieces and take one of those pieces a day…as well as NR. These pieces are near my limit where I would get a niacin flush. I have never been able to increase the dose and not have the flush. They say it is harmless. Tires me out. I used to take time release, but I heard there was a risk of liver damage.

  9. I have been looking into this a bit more, and it may not really be the toxins at all. They now think that removing all the plasma and replacing it, triggers feedback mechanisms that replace stuff and in so doing rejuvenate things. It provides some sort of reset.
    However, that fails to explain why the young mice had their health decline as the older mice got healthier, so the toxin explanation is not totally busted, in my opinion. And both of these things could be going on.

  10. We are not totally helpless with environment. I use a HEPA filter when I sleep. At least there is 7 hours or so with clean air. Some cars have good air filtration. If the air in your city is not excellent, indoor exercise may be a better choice if that air is very clean.
    I use reverse osmosis for the water I cook with or drink.
    Depending on where you live, the milk you drink…if you drink milk…may have a large range of iodine levels. And you can't just go by where the dairy farm is located, it maters where they get their hay.
    One drop of Lugal's solution Iodine a week, and that is one more base covered. A bottle will last for years. I put it in my scrambled eggs, tastes fine there. Lousy in a glass of water.
    Iodine is good for the immune system and many other things…but it also protects you in the event of a severe reactor meltdown. If your body is very hungry for iodine, it will gather iodine any way it can: skin contact, the air, or food. It does not distinguish radioactive from the non radioactive stuff. And unlike other radioactive stuff nearly all the iodine you get gets taken to one place and concentrated, the thyroid. When radioactivity is concentrated, the DNA damage rate can exceed the DNA repair rate in that tissue.
    There are some areas where there are difficult to deal with issues. It is best to be a few miles away from any busy small airport, as the small airplanes are still using leaded gasoline. And you don't want to be close to an outdoor firing range.

  11. Forget carrots. They have way too much lead. Yams unfortunately also may have lead. Pumpkin is good…though pumpkin pie is probably dubious. I eat a lot of butternut squash which is not as rich in these as pumpkin, but I like it more and it is easier to get fresh. Kale is important for some of those other carotenes, and tomato even as paste is great source of lycopene.

    The lead foods are: carrots, rice (you can boil for 7 minuets, toss the water, and finish boiling. That removes most of the lead), yams, any grape product especially balsamic vinegar, and chocolate. Not all chocolate has lead, but it is Russian Roulette. There is a site where they have tested it, but suppliers can change, and you would not know.

    Low level lead exposure matters. 18% of all deaths in the US are due to lead. It causes high blood pressure and other issues associated with heart disease.

    As far as alcohol, at low consumption, there is probably something else that will kill you first. Even if those things don't have the level of proof you are asking for.

  12. Cool, thanks for sharing your journey to journey further.

    I take ginseng, B vitamins (Niacin being a precursor to NAD?), D, NAC + Glycine. Varying TCM patent formulas as needed.

  13. After you kill off a bunch of senescent cells, your remaining cell population has to multiply in order to compensate for the loss of those cells. This causes the average telomere length to shorten. So that's why I use senolytics sparingly, and typically at the end of vigorous cardiovascular exercise.

  14. Thanks for the list.
    Some of those 'to avoid' things depend a lot on where you live, & the question becomes 'Can I afford to move?'. So for those who can't it is necessarily environmental regulations to clean up the area.
    I will look up HIIT to determine how close what I am doing comes to qualifying & how I should change my exercise routine.

  15. I had heard about the alcohol now known to be always bad. I have never been drinking more than one glass of beer or wine every week or two. For the last several years I haven't had any alcohol.
    Where does the Carotene hit diminishing returns? I've been eating a carrot stick every day for ages.
    How much fat is 'too much'?

  16. Which raises the question of what does marriage to a younger man do to the mortality risk of a woman?
    Edit: now that I have looked at the link I see that it doesn't help.

  17. In my humble opinion, B3 is a very potent drug. I´ve never been on Nicotinamide so long as 9 months as you. My normalk dosage is 0.5mg during 5 days a week, one month on and one month off. I suppose that people does a research befor to try such novel treatments to discover that B3 is potent and, depending on the B3 type, some side effects can arise.
    I think also that NMN should be used with some caution because its notable effects. I never noticed your side effects with collagen, but I will be attent.
    In any case, many thanks for your feedback.

  18. I think the most important thing to do at this point, Brian, is to get a good measure of your biological age. There are many epigenetic age tests. I would suggest taking several copies of the same test at around the same time, then a year later. You really need a test that delivers an accuracy of 0.5 years or less. If the test promises an accuracy of +-1 year, then take it 4 times (if you can afford it). You cannot know if you are getting a slow down or even a modest reversal in biological aging, unless you can measure it.

  19. Life Extension Foundation has done a pretty good job trying to get new potentially useful or better form supplements out there. Of course they are not the wonder treatments we have been promised from SENS.

    Though, if they had these cures, they would not be cheap, and you would likely have to go through a doctor.

  20. I could not even get on my knees without painful bruising occurring (and that was with foam knee pads). I could not walk without my knees popping out of joint. I had something like tennis elbow in my right elbow, I injured and re-injured my thumb over and over. My ankles were hurting. And I was quickly getting lines on my face, when my face was looking very young for my age to that point. Though, it is possible masking was a factor, as I was using N95 masks and the elastic is pretty tight as I have a fairly large head.
    It took time, but I fully recovered. Even my face improved a little.
    I am sure I did not have gout or anything, as I don't drink, and I eat mostly very healthy things. My inflammation numbers are also very good…well…this was tested a few months after I quit the niacinamide.
    It is possible it blocked something other than collagen. Perhaps hyaluronic acid or elastin? But, I assumed collagen, as that Doctor mentioned this possible side effect.

  21. The problem with studies on alcohol is that people who have been instructed by their doctors' not to drink because their health is already damaged get included with the others who don't drink by lifestyle choice. As a result, whatever the smallest level of consumption is that is not zero, appears healthier.

    And chronic inflammation is definitely bad! C-Reactive Protein is a measure of that. The worst is Smoking at .44 but C-Reactive Protein is the next worst at .28 The best positive is Alpha Carotene at -.28
    And the macronutrient results fly in the face of the hip diets of today. Carbohydrates are good, too much fat is bad, and protein is neutral.
    Obesity bad.
    High blood sugar bad.

  22. Avoiding lead.
    Clean air.
    Treating sleep apnea, if you have it.
    Avoiding asbestos and quite a few other carcinogens.
    Recently, they moved alcohol from "suspected carcinogen" to "known carcinogen" as they now have very robust evidence.
    Trans Fats are definitely bad, but the FDA finally finished its more than a decade long foot drag. So it should not be in too many foods in the US.
    High Intensity Interval Training (HIIT) has been shown to be the best exercise tested for mitochondrial health. Cardio is probably still best for cardiovascular system.
    Obesity is bad. But a bit overweight is actually beneficial for the elderly.

    Diet is interesting. We have exceedingly accurate methylation clocks that show biological age vs chronological age. The beauty of this is that we can now see what diet and lifestyle affects without waiting decades and decades for people to die. The data is still correlation and not necessarily causation, but I think it is a gold mine. Go to the first colored column in Figure 6
    There you can see what extends health and life and what shortens health and life. There are issues I think. I think Gamma Tocopherol has a bad result because people are getting it in their diet from margarine and shortening rather than nuts, seeds, and whole grains. And the alchohol suffers the same flaw as other studies.

  23. It will, we will have super smart AGI in a matter of years, and it will accelerate aging research at least thousand fold. We will have AGI and reversing aging tech before 2030.

  24. What are the things someone can do that is super well established for improving health?
    The things I know are good that I do:
    1) something to not do. Smoke. I have never smoked, though I had exposure to 2nd hand smoke since my parents smoked.
    2) exercise. For most of my life I have made a point of getting some sort of physical activity every day or 2. Both strength training & some sort of cardio.
    3) sleep. 7 or 8 hours out of 24.
    4) diet? What is recommended as good or bad to eat for your health varies a lot over the decades.

    Is there anything aside from those 1st 3 that is really well established as good for ones health? I want to put my effort into those things that are most likely to actually do me good. The cutting edge research is necessarily on things we don't yet know are helpful.

  25. There are certainly things you can do on the cheap. Diet (lots of butternut squash/pumpkin, kale, tomato/tomato paste), exercise (HIIT and cardio), regular sleep, relaxing music/meditation, hot then cold shower to boost sirtuins, fasting/fasting mimicking. You can make your own weights for weight training (quads are good for natural increase in testosterone). Grape seed extract is cheap…did not used to be decades ago, but it is now. And it has a potent senolytic in it (PCC1). Quercitin is also pretty cheap, though high demand during the pandemic did cause some prices to climb. I bought mine bulk a few years ago. Fisetin may still be worth the extra money, because it appears to be a α-Klotho booster. I think lecithin is very under rated. And it is pretty cheap. People talk salmon…I talk salmon, but tuna is very healthy too, and quite a bit cheaper. And the farmed salmon has more of the stuff you buy salmon for vs the more expensive wild salmon. Iodine I think is also underestimated and cheap. I bought my Lugal's Iodine (that is not a brand), for less than $10 and I am about 80% out after 3 years. Only need a drop or two a week. Best to get magnesium. Not terribly expensive. I take it before bed.

    There are however things that even a penny pincher should concider: A HEPA air filter in their room as they sleep, and ear plugs if you need them (I just use cotton and put it on medium). At least you get a few hours with nice clean air. Reverse osmosis for cooking & drinking.

  26. Strength training helps as well. Good for bones, blood glucose and lowers your blood pressure; my systolic has dropped about 10 mm and it has historically been 120.

  27. No! I tried this. High doses of Nicotinamide (also known as Niacinamide) caused me to stop making collagen or dramatically down regulated it. All my joints were hurting, and I was being injured very easily. It took around 9 months to really get serious problems, but I was suffering. It was fortunate that I heard Dr. David Sinclair mention this in a video. He is in a lot of videos, I don't know which one.
    I dropped it immediately when I heard. And slowly things returned to normal. This side effect is listed nowhere, that I could find. In fact, several sources say it helps in the production of collagen. Though it is not unusual that something that acts toward something at one dose acts against it at another.
    Your results may very.

  28. I still think we get the biggest gains by identifying what things are really the most likely to kill us, and tackling the top 1, 2 or 3. I am not talking the 3 top causes of death in the US. I am talking what is likely to kill YOU. You find this out by family history, a battery of tests and by looking at your DNA. You can get any genotyping done, download your DNA file, then upload it to Promethease. They process it for $12. And you get back a massive report. The bad and good genes are given numbers. Anything bad over 2 you should take a look at. 4 and above you need to take very seriously. Research your likely future conditions and figure out a plan to minimize the risk of these. The ones they say are related to a drug…like "poor metabolizer" are not any big deal. They are things to be aware of, so if a doctor prescribes it, you can tell them and get an appropriate dose. I don't see that as a problem with your genes as much as it is a problem with our current medicines.
    One nice thing is that it suggests more specific cancers rather than cancer in general, so you can target those for prevention.
    I am not saying you should drop all the other health advise. Follow the general stuff. But researching every last thing that can kill you and acting to stop them all, will just put you in a prison and unable to live life. And what may help one thing may hurt another.
    I admit this is a probability game. To benefit from the approach, you have to not get unlucky.

  29. There are many useful things in meat. There are some concerning things: heme, and trans fat (both in beef). Potentially parasites, viruses and such. But the real danger is in how meat is processed. I mean high temperature cooking and blending with machines to make things like hot dogs. If the chunks are large in the processed meat, it may not be bad. If it is finely blended, it is almost certainly not fit to eat.
    Optimal meat is probably 10% to 20% of calories.
    As you age, a number of processes that worked when younger, work poorly. The body can't easily convert the vegetarian Omega 3 to DHA and EPA. It can't convert beta carotene to vitamin A at needed levels. Some of the minerals are not easily absorbed from vegetarian sources by the elderly. And there are things for brain, eyes, and joints you just can't get from plants. Skipping eggs, and fish is almost certainly dubious.
    We eat too much muscle and too little of the rest of the animals. Gelatin has a bunch of that. And people live longer with dairy. Eggs are fantastic when cooked properly.

  30. Senolytic treatments seemed to me to be the best starting point. Via foreign distributors, I secured & used Dasatinib and Quercetin a few times now at (roughly) 9-month intervals. Other than that, I use metformin, supplements, and exercise.

    I look forward to hearing more about your progress.

  31. Think of it this way. If the 57 y.o. is expected to die at 81, what about a 82 y.o. ? She is absolutely guaranteed to make it to 82, at least.

  32. so I understand (as a living) we all die, sooner or later.
    Maybe it is more useful to study what lays behind death, than pushing the limit?

  33. You don´t need NMN to increase NAD+ levels. This is quite expensive. You can have the same results using B3 in the form of Nicotinamide (to reduce some side effects of other B3 forms) in a 1/20 costs of the NMN. 0.5g a day is enough. This is not the "poor man NMN", it really increases in body NMN levels via NAMPT encime at a fraction of the oral NMN cost. And using Nicotinamide you are probably buying the right stuff and not a fake NMN as sometimes occurs from untrusted sources.
    Please see:

  34. Yes.

    Keep in mind that I'm in my 60's; The goal for me wasn't to subtly encourage senescent cells to die, it was to kill off decades worth of accumulated ones. So I wasn't aiming for a maintenance dose. My look at the literature suggested a high enough dose that you wouldn't want to do it continuously was appropriate.

  35. No, I think it is the other way around. The cell has extra energy to do the housecleaning and maintenance of the cell, and all the ordinary operations, meaning less cellular damage, better regulation of processes and likely longer life for the cell. When it runs low on energy, bad things happen like mistakes in DNA repairs, and garbage is not reprocessed as quickly, and can accumulate. DNA in each cell is damaged 10,000+ times a day, and hopefully repaired as often and correctly. Mistakes in the creation of proteins are not taken care of rapidly if there is little energy. Cells never try to repair errant proteins, they are disassembled and this is a very inefficient process, taking sometimes thousands of ATP molecules to shred one protein…but that is just the way cells work. If mistakes are made faster than they can be shredded, and especially if they are misfolded proteins, they can escape the cell and very bad things can happen. The mechanisms to digest random errors are in the cells not outside the cells. If it is close to what it is supposed to be outside the cell, it might be recognized and broken down out there by the normal protein regulating machinery. If it is unrecognizable, the body may have no solution and it just accumulates, probably as some form of amyloid plaque.
    A better analogy is that we are giving the machinery a bit of oil to run smother or you can think of it as giving it more currency to pay for things it wants to do.

  36. Cut animal products out of your diet and you'll reduce your chances for most of the diseases of aging Brian.

  37. Kudos to Brian for getting serious about longevity. I'm over 30 now and have recently started running daily. I doubt anti-aging tech will arrive in my lifetime but even a small chance is better than nothing.

  38. Users report recovery from exercise being much better when NAD+ boosting, but otherwise report only subtle effects most of the time, so your experience is very typical.

    I suppose I wasn't being clear, that it isn't raising your whole metabolism, with the aim of burning energy, but rather is accelerating (restoring?) the speediness of cellular metabolic cycles directly, so you are in theory putting more wear-and-tear on your cells. Running an engine faster (or at faster idle) isn't always a good thing…

  39. A 57-year-old might die during the years between 57 and 78. But a 78-year-old definitely did NOT die during those years. So the 78 year old will, on average, live to an older age.

  40. His results indicated 1.5yr of "age reversal" by DNA methylation clocks per year of treatment; most remarkable because he uses a drug cocktail of HGH, DHEA & Metformin. Off-the shelf relatively inexpensive available to the general public meds.

  41. Structural dysregulation in the nucleus, including ds break signaling from shortened telomeres, is often a driver of senescence. This can continue throughout the transition and for as long as the cell survives. 

    But clearing senescent cells is unlikely to negatively impact their neighbors telomere length, quite the opposite since a source of pro-inflammatory cytokines has been removed. Whether senolytics place additional stress on the remaining replicative cell population through forced remodeling and mitosis (and/or differentiation) is not clear (to me) yet.

    Therefore, propping up your telomere length after a spaced round of senolytics makes sense. As Windbreaker says, not much in the way of financially accessible options right now though.

  42. As a last-ditch method, there's always Cryonics, but be careful where you have it done:

    They Were Russia’s Cryonics Power Couple. Now They’re Fighting Over the Frozen Brains.

    "A very messy breakup between the husband-wife duo who run Europe’s only cryonics storage center has spiraled into brain heists and corpse-snatching."


  43. I don't understand how to read the actuarial tables. It looks like a man today at the age of 57 has 24.10 years left, dying at age 81, but someone 78 years old has 8.98 years left, so they die at 87. How does a current 57 year old have a shorter life expectancy than a current 78 year old?

  44. I think Metformin and likely Berberine are suboptimal. You lose the ability to benefit from exercise. And I have experienced this first hand. Before I ever heard of this issue, I took up walking…and walking…and walking. It seemed like it did nothing for me but make me tired. I quit the metformin. Now exercise works. I needed exercise to work. I am not in the condition I want to be in, the rest of my life.
    If you never plan to exercise…fine.

  45. Young plasma infusions are silly. The science has shown that the reason the old mice benefited from being connected to the young mice was that there were toxins in the old mouse plasma. You don't need young plasma, you just need your plasma removed and replaced with albumen and saline. This is a procedure called plasmapheresis. You also would have a much reduced risk of catching something that you might get in a transfusion from another person.

  46. It does not raise your temperature. It is not like red pepper or other stuff that raises your metabolism making you burn more fuel. I think it just allows cellular processes to operate more like when you were younger. At least that is my impression. I take 600 mg of NR, 300 mg in the morning and 300 mg in the afternoon.
    If it does, it is very subtle.

  47. Cycloastragenol is supposed to be the molecule in the Astragalus that extends telomers. Pretty pricey stuff.

  48. Strategically, I think it makes more sense to remove the senescent cells first. You don't want to help out the senescent cells by lengthening their telomers. When they become senescent the DNA rips apart and the ends fray. This reactivates the production of a large number of unneeded proteins. If they are glued back together by giving them a telomere again, they are just going to keep pumping out crud. These cells also damage and even eat the cells around them, even if they are healthy cells with nice long telomeres.

    But if you do want to lengthen your telomeres, Astragalus extract is supposed to help with that (or if you are loaded, you can take the proven TA-65). Though, not every variety of Astragalus has the molecule that does it. Also, it may be limited to a few cell types in the cardiovascular system. Hyperbaric oxygen therapy is also supposed to lengthen telomeres. And I think there are some lifestyle interventions that can slow the erosion of telomeres. And making sure you have all the antioxidants needed by each organ should help.

    At 80 or 90, strategically, it might be best to just do both. Still, the first treatment for me would be senescent cell clearance. Maybe the first treatment will get the worst of them.

    I also think fasting or fasting mimicking is best at the same time as taking the senolytics. And they have discovered that there is something in grapeseed extract that has good senolytic properties. And I am not talking about Resveratrol.
    Not advise.

  49. Hope you're taking yogurt or something with a little fat in it with your NAD+ supplements.

    Though NAD+/NMN has been called a metabolic accelerator. Which means you may feel more pep, but you may be burning the candle faster, so to speak.

  50. Yup, exercise and diet do more than anything else. How exactly and for who at what point is still up for debate.

  51. Funny how people go on spending a lot of money but forget the inexpensive/less expensive basics, not saying it's the case and this looks like it's a sponsored article. If you got serious about the subject it would be nice to see your plans for the daily/weekly routine, I mean, diet, supplements, exercise, work/rest/sleep schedules, objectives/goals…

  52. The only thing I think most would agree on, is that SENS treatments are taking too damn long to arrive.

    I have been hearing about them since I frequent the site, and that dates more than 10 years ago.

  53. I was recently listening to a podcast by Dr Peter Attia and, if I recall correctly, he mentioned that NAD could possibly increase tumor growth. This could potentially cause smaller, undetected tumors to increase in size.

  54. Oh yes. I started in the mid 90s with Chromium Picolinate. Things have gotten a lot more complicated since.

    I did the whole spreadsheets and life expectancy at various ages, too. It's reassuring to have most of the previous generation still alive, too.

    All your stuff looks familiar. If my list was updated, I would post it.

    You might want to look at Goat's Rue as a next best for Metformin.

    Be very careful of potential liver damage from some stuff, or taking too much of any stuff.

    The thing to remember is that, if a little is good, more is not always better.

  55. I have had some positive results with high dose Quercetin; Some lesions on my hands, sun damaged skin that had become very thin after cryo-treatment at the dermatologist, became inflamed when I took 3g once a month. Each time the lesions healed back a bit more normal looking.

    I wouldn't say they made it all the way back to normal, but that skin was quite fragile prior to using Quercein, now it doesn't give me trouble.

    BTW, after about four such treatments, I stopped noticing any further inflammation, so I'd apparently gotten rid of any cells in the lesions that were susceptible to it.

  56. I've been using Fisetin for years, but I use it infrequently – like once every 6 months – because I feel concerned that such senolytics can have an overall negative effect on average telomere length. I'm really more interested in ways to lengthen the telomeres, because I feel that's key.

  57. Your Donotage.products link just leads back to this post. Might want to fix it.

    I might just check that out.

    Have you considered enrolling in Dr. Fahy's thymus regeneration trial? He seems to be having some real success with it, I only wish I were in a position to join it. Depending on where you're located in meat-space, you might be able to.

    I've been reluctant to do any aging tests like this, on account of not wanting the bad news. (Having gone through chemotherapy, I'm probably a lot older biologically than my birth date suggests.) I suppose that's irrational, but I enjoying imagining that I can expect a normal lifespan.

    I suppose I should bite the bullet and learn the presumptively bad news.

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