Aubrey de Grey spoke at his Longevity Summit Dublin conference. He has created a new antiaging foundation.
They will combine stem cells and senolytic interventions. They will partner with iChor.
IChor’s lab is able to perform large mouse studies.
They will be able to test many other combinations of aging damage interventions.
They will perform the interventions on mice that have no special treatment up until middle age. This means two year old mice that normally live 3-4 years. If the combination therapies enable many of the mice to live to 5-6 years of age with greater health then they would clearly demonstrate strong combination aging intervention beyond calorie restriction.
Nextbigfuture interviewed Aubrey de Grey about one month before the Longevity Summit Dublin.
Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.
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Why not go the George Church route and treat dogs instead of mice? Nobody cares much about mice but folks love their pet dogs. You would 1) Test subject that is also a paying customer. 2)Free advertising for the efficacy of said treatment; each treated pooch is a poster child for the success of the protocol 3) A stand alone profitable business in its own right even if (unlikely) said treatment only works on dog, never translates to people. 4) Exactly the kind of person who would be a potential investor and/or customer would be someone who could afford expensive (to start with) treatments for their beloved “fi-fi”. A well-heeled person who likely has wealthy friends as well who would quickly take notice if said pet starts looks/acting much younger; “Hey when/where can I get some of what your dog is getting?” etc.
And also 5) The approvals process for a health/longevity treatments for dogs/cats is vastly faster time wise and cheaper than for people.
I think George Church started from mice too. Dogs/cats would take a lot longer to get clear results, and this really should be tested on mice before being tested on people’s pets.
“Dogs/cats would take a lot longer to get clear results…”
If a 12 year old Labrador Retriever was treated for instance I don’t think it would take that long to see results. Not just ultimate life span but prior to that general appearance, vigor, alertness energy etc.
They intend to use this at middle age, not end-of-life: “two year old mice that normally live 3-4 years.” These therapies are less likely to be successful at end-of-life. So for a labrador with a total life expectancy of 12 years, they would want to use those at 6-7 yo. That means upwards of 6 years to see clear proof of longevity extension. Generally speaking, the longer-lived the subject, the longer it would take to see the results.
They may be able to see *some* preliminary results before then, but it’s not as clear-cut. I’m sure they’ll move on to dogs etc after the mice tests are successful.
“So for a labrador with a total life expectancy of 12 years, they would want to use those at 6-7”
For mice they did because they have a shorter life expectancy. They might use dogs age 9-10; not necessarily 12years (or 6-7). After all its not set in stone they could adjust the ages they use accordingly. Don’t know what age Church is using for instance. Also haven’t heard much about how that is going?
“They might use dogs age 9-10”
That would be a completely different experiment, roughly equivalent to testing the treatments on 80yo patients vs 60yo. They might do both, though. At some point.
And they’re not going to check the importance of maintaining a clean liver through a proper diet. Weird.
Because modern allopathic medicine isn’t about following ascetic lifestyle changes. There’s a whole market of alternative therapies for that.
What they are researching is on how to eat your cake and have it too.
Without any changes to your habits, how you can still be healthier and live longer.
Good to see some more attention to stem cell therapy in the context of SENS treatments, and especially as a complementary treatment to senolytics. If they’re starting with 2yo mice, that means we’ll see the results in 2-4 years, though there may be early signs before then.
I wonder if it would be possible to do partial in-vivo reprogramming to regenerate stem cell reserves. That’s more up George Church’s alley.
“They will combine stem cells and senolytic interventions.”
You mean like this?
https://www.longecity.org/forum/topic/100363-stem-cell-self-renewal-with-c60/page-66#entry917974