Rejuvant Antiaging Supplement Studies Show Large Biomarker Age Reversal

I, Brian Wang, have started taking Rejuvant time released AKG. AKG is safely used by millions for bodybuilders and athletes. Time-released AKG from Rejuvant is used for healthier aging.

I personally have been taking Rejuvant for a month and half. I also started with an aging biomarker test and a spit test analysis. The analysis found that I had genetics that reduced my absorption of Vitamin B. I am now taking Vitamin B supplements along with Rejuvant. I will taking another aging biomarker tests after the six months of Rejuvant. If I was like the average of a previous study, I would expect to see about an eight year reduction in the aging biomarker.

Rejuvant has human medical studies where aging biomarkers have been reversed to reduce measured biological age. There is more than the single case as the study looked at hundreds of people.

Tom Weldon, the founder and CEO of Ponce de Leon Health, has accomplished longevity escape velocity with one supplement, his own Rejuvant.

This chart shows the measurements. There are error bars but the midpoints indicate that over a three 6 months courses of using Rejuvant every day he has his measured biological age reduce from 52 down to 45. Tom Weldon is 67 years old. If this is accurate, then it would suggest he is squaring the health curve. According to biomarkers he is getting substantially healthier.

I would interpret effect to mean that people can be far healthier up to 80 to 95 but then aging damage still reaches critical levels to cause aging diseases.

I would cite the example of the fitness guru, Jack LaLanne. Jack was fanatical about eating right and exercising. Jack has amazing feats of fitness into his 80s. https://rejuvantsale.com/

Use code BIGFUTURE for a discount.

Antiaging Studies and Investigation

Ongoing studies are being performed in Singapore. Brian Kennedy is working at the National University of Singapore to study this as part of means to achieve a five-year increase in healthspan for all people in Singapore. Kennedy is collaborating with Rejuvant.

Brian Kennedy indicates he agrees with the Aubrey dr Grey / SENS analysis of seven kinds of aging damage.

The first research theme funded under the ‘Hacking Aging’ initiative is a series of clinical studies to test novel nutritional supplements and repurposed drugs to slow ageing in middle-aged adults (40-60 years).

At least 15 biomarker studies are ongoing, including Project Abios (Ageing Biomarker Study in Singaporeans) which is looking at several hundred biomarkers in 420 to 450 participants.

The second research theme is to use deep omics data to personalize these supplements and repurposed drugs and other interventions for optimal healthspan extension in middle-aged participants.

One of the supplements is alpha-ketoglutarate, which has been shown to increase the healthspan – the period of life spent in good health – and lifespan in mice. The centre will be investigating whether six months of daily supplementation can slow biological aging and initial results are estimated to be available in a year’s time, said Professor Andrea Maier, the centre’s co-director. Repurposed drugs include metformin, a well-known drug used to treat Type 2 diabetes, that may be able to slow ageing.

The third research theme focuses on extending healthspan in older adults through strength training exercise, harnessing the Foundation’s Gym Tonic community of seniors.

Professor Brian Kennedy, internationally recognized for his research into the biology of aging and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human aging and its associated diseases, is helming the Centre with co-director, Professor Andrea Maier, an internal medicine specialist renowned for translational research in aging and age-related diseases diagnostics and pharmacological and non-pharmacological interventions in aging humans.

The 1,600 square feet Centre for Healthy Longevity (CHL) located at Alexandra Hospital, will conduct trials and execute validation studies with healthy participants from the age of 30 years. The Centre will also develop and test these interventions using newly identified biomarkers of human aging. Once approaches are validated, the Centre will develop strategies that integrate a combination of nutritional and exercise approaches together with supplements and (repurposed) drugs for personalized adoption in the Singapore population. The ultimate goal is to bring the individual closer to his/her state of optimal peak performance during the entire lifespan (e.g. screening to start from 30 years of age).

CHL will be looking at blood-based biomarkers, probably the most investigated group due to the large amount of data accumulated in clinical trials.

Many Well Funded Efforts

There are many well funded antiaging efforts. Saudi Arabia has the Hevolution fund which invests $1 billion every year into antiaging.

There are over 158 companies working on antiaging. There are over 340 clinical trials. They have a market cap of over $6 billion. They have over $10 billion in funding. There are over 5000 employees at the antiaging companies.

25 thoughts on “Rejuvant Antiaging Supplement Studies Show Large Biomarker Age Reversal”

  1. Terrible shame they made it with rice bran. People with allergies to rice will get sick from it. Why do so many companies making digestive supplements that could benefit patients with allergies, autoimmune disorders and dysbiosis of the gut make pills with non-hypoallergenic ingredients that can aggravate all these conditions?

    FYI, aluminum poisoning damages both mitochondrial metabolism and digestive enzyme production by suppressing AKG levels – which can foster dysbiosis and the chronic inflammation underlying these problems I mentioned.

  2. I’ve been taking it since the first article here, last fall. I just got the second test (7 month point?) a few days ago. I’ll try to stay healthy until the weekend, then mail it in then. Obviously, I’m curious, both about how much, if any, improvement, I’ll see, and if the test even means anything.

    My only complaint (besides the price) is the enormous size of these round pills. I’d rather swallow 4 smaller ones rather than 2 enormous one, a capsule shape would help, too.

  3. I think that there is a lot of potential for now and future supplements to ‘optimize’ the current range and availability of nutrients and their intake. When combined with a minimum of 90min+/week of HIIT exercise and 4-5x that of just moderate ‘movement’ that utilizes some strength, cardio, and flexibility, we can establish the best possible platform of health to possibly get in on an early vector of longevity escape velocity, if under 70-ish. There may even be a few minor body hacks – fasting, that I consider self-suffering, which may provide a few more years, but at the end of the day the healthy body with near-idealized genetics, environment, and self-monitoring will top out at not much more than 120, with significant functionality a decade less – which is still great, considering. But only through medical intervention, upgrade, localized replacement — and otherwise ‘overclocking’ your existing auto-immune, senescent cell management, and repair/ robustness ‘systems’ can we extend healthy life span. Point: taking these will not likely significant offset previous self-inflicted lifestyle choices. I personally think that medical tourism and extra-FDA facilities will be the vanguard of adding healthy decades, possibly in under-developed countires/ regions.

  4. On the Rejuvant website, it says Tom Weldon is 67, not 52. It’s a lot more impressive for a 67-year old man to set his biological age back to 47….though less so since he started with a biological age of ~53 (see chart at site: https://www.globenewswire.com/news-release/2023/03/28/2635803/0/en/67-Year-Old-Founder-of-Ponce-De-Leon-Health-Achieves-Longevity-Escape-Velocity-with-Rejuvant.html). There is a wide band of biological age shown, however, presumably due to uncertainty and different individual markers, and the final upper range after 2.5 years overlaps slightly with the original lower range. In his pictures, he looks like a typical middle-aged man with adipose spread, slightly overweight.
    The AKG supplement is the only part one wouldn’t normally get from a well-rounded diet; I take supplemental vitamin D3+K2 (for absorption) since most people don’t spend enough times outdoors to get enough vitamin D. I think this might have helped my recent Calcium CT score in a cat scan show 0% blockage in my arteries, despite having high cholesterol for decades (eating a nearly zero-added sugar diet and regular exercise, beyond what Weldon does, probably helps too).
    Still, the forced closure of my gym due to Covid lockdowns and the loss due to layoff of my personal trainer of 14 years, did more to set me back than any supplement could probably make up for.
    Covid lockdowns probably hurt more Americans than Covid itself; it wasn’t clear at the time to most people what the long-term effects of the lockdowns were, but they are pretty severe and semi-permanent.
    People age at vastly different rates, based on lifestyles mostly, not genetics. Most supplements are a waste of money and/or not specific to the individual’s needs. Maybe AI will eventually tailor those to personal recommendations, but there may be no business model for such fine-tuned prescriptions.

    • Something like 30 different approaches to radical life extension being undertaken by a lot more players than that.

      It doesn’t seem unlikely that one of more of them may hit some serious paydirt soonish.

      The questions being:
      1) How soon?
      2) How long to complete human testing?
      3) When will it hit the market?
      4) How much will it cost?
      5) Will it necessarily involve medical tourism?
      6) Will different successful treatments stack with each other?

      The first method to come into common use doesn’t have to be the best, or the cheapest, it just has to buy time to find the next. It seems unlikely but, for all we know, the first person to live to be a thousand was born before WWII.

      A few things to bear in mind regarding social issues.
      1) Extensions run out and not all will be equally effective or equally available.
      2) Something that didn’t merely slow aging but which would maintain people at their current age would be useful but, balanced on the edge like that, would likely be quickly supplanted by something allowing at least some actual rejuvenation.
      3) Overpopulation is unlikely as people at the bottom end of the global top 1% in income could scarcely afford to buy a fancy caffeinated beverage at Starbucks every day, let alone for their spouse and other family members, and I have little expectation that any efficacious treatment would cost less than that.
      4) It does lend itself to greatly expanded income/wealth inequality. Warren Buffet became a billionaire at 57. In his 90s he is now worth more than 100 billion. Now imagine what it would do the world if he was going to live to, say, even just 200. And he would not be the only one. Society would likely revert to feudalism (where the kings owned everything and just let other people have the use of their stuff in exchange for fealty and other considerations), breakdown completely, or a lot of multi-multi billionaires are going to be very unhappy with some draconian measures to prevent them from absorbing all the wealth on the planet (like the little boy crying with a loaf of bread under his arm). But how annoying to become almost immortal and then be ripped apart by legions of impoverished 99.9 percenters.
      5) It’s possible most long-lived people are going to become rich. And most people, even the very rich, tend to work. The rich tend to work at what they want to work at, where they want to work, when they want to work, only as hard as they want to work, and they don’t have to earn a living wage at it but, oddly enough, most of them do something akin to work.

      No idea what this will mean in conjunction with cognitive automation producing occupational displacement on a massive scale. Also, I can imagine someone on a plane telling me he is a professional golfer and, when I ask how that’s working out for him, he proudly tells me he won nearly two hundred dollars in tournament prizes last year.

      Potential personal downsides:
      1) It is also possible our brains aren’t wired to survive more than a couple of centuries, regardless of how healthy our cells are.
      2) It is possible extreme ennui could lead to many people becoming extreme risk takers after a few hundred years, until the odds catch up with them.
      3) A population that does not die to diseases of old age (or cancer, etc.), and even discounting suicides (which would include taking up extreme sports at the age of 400), will still probably have a half life of something around a thousand years (train crash, meteor strike, school shooting, accidental poisoning, etc.).
      4) The bad part about eliminating all the relatively peaceful ways to die implies that your inevitable death will likely be rather violent and potentially messy, although hopefully not protracted.
      7) Survival methods that involve uploading the mind to an inorganic form make us question who is actually surviving. As does backing up copies for restoration in case of accident.
      8) Replacing your body’s cells, or collections of cells, with clever nanobots, done gradually over a long period of time, seems like it would avoid many of the potential downsides of living that long, but it raises the Ship of Theseus question. Of course, one could also argue that, given that our cells replace themselves over time anyway, does that even matter?

    • Perhaps you can find something at amazon.de or similar: Alpha-Ketoglutarate (AKG) and the dosage has to be right.

      The problem is what is in that cheap supplements, I wouldn’t use them if enough testing was done and supplier is reliable.

      • I’m always a bit bothered by supplements that are purported to have important medical effects, and yet the dose is just a given amount for “men”, and maybe a different amount for “women”. Rather than mg/kg.

        As though you didn’t have a huge range in size between different people; My wife, for instance, is maybe 40kg, soaking wet. (She’s not anorexic, just short with a slim build.) That’s on the low side for the Philippines, where she’s from, even, and is half the average weight for American women.

        At 93kg, I’m about average for an American man, so I’m probably getting a reasonable dose at the recommended 1000mg.

        Of course, the same problem exists for actual prescription drugs. It’s crazy.

        • Can you imagine the logistical and safety issues with tailoring pills to body mass, though? Custom blister packs with medicine dosed to two or three significant figures would cost a fortune, and increases the risk of accidental overdose by process error. Splitting them up into smaller doses removes the convenience aspect of having a pill. I’m not sure what the solution is, but “good enough” may have to be good enough.

          • In this case it’s already split into two capsules, because some people have trouble swallowing large capsules. Formally recommending that you take 1, 2, or 3 depending on your body weight wouldn’t be that tough.

          • I didn’t mean tailoring them to body mass. The supplement producers can make big beautiful designed jars with many pills and claimed super effects. But the each pill can have so little of necessary ingredient, you need to take a lot more of them for any effect. Some of them may lack necessary secondary ingredients for better results.

            As I talked to pharmacists, they said how little regulated is supplement market. The package can be great, beautiful, full of claims of miracle effects. On the other hand you can swallow garbage, here people need to be careful.

            That is similar to one high school experiment we had. They put the same chips in different packing. They didn’t tell us that. Then we had to rate it. People were rating the same chips based on the different packing as better taste than others,… I think I was one of the rare ones or the only one who figured it is the same chips, just the packing is different.

      • Thanks, Day33! I think I’m going to wait till something more affordable comes along and is sold in Portugal.

  5. As a Type II diabetic I’m curious how this interacts with, or works alongside of, what I’m already on (metformin, gemfibrozil, Rybelsus, among other things… including B12 because metformin inhibits absorption of B12). BTW, I’ve been on metformin & gemfibrozil for almost 25 years… and aside from a bit of arthritis & some grey hair, I’m in better shape than I was 30-40 years ago.

  6. Hope it will work for you Brian! Publish the results after 6 months. It would be interesting if you stopped taking the supplement after 6 months and if works try another test after 9 months to see if after 3 months without the supplement you still have some positive effects from it.

    https://www.longecity.org/forum

  7. Don’t get me wrong, but I already take Vitamin A, and get plenty of calcium, so the only thing in this I don’t already take as part of my supplement regime is the AKG. And that I can get as a separate supplement for a third that price.

    How much is the aging bio-marker test, by itself?

      • If that’s the right test, then I’m actually much better off purchasing the AKG and the test separately.

        $186 for two biomarker tests, and a 3 month supply of AKG for $30, combined cost $216.

        Even with the year subscription, the Rejuvant costs $100 a month.

        The Vitamin A and Calcium content of Rejuvant aren’t anything special, anybody who takes care of their nutrition is already getting that much of both.

        • I don’t actually know anything about the molecular biology of it, but I expect the calcium is modifying the transport characteristics or stability of the AKG. But even then, there are cheaper places to by CaAKG.

          • Do you know if it has to be calcium AKG? Would Arginine AKG work when taken alongside calcium and vitamin A?

            • I don’t know anything about the relative merits of Arginine-AKG vs Calcium-AKG, you would have to examine their clinical evidence separately and compare. But I wouldn’t count on a separate Ca supplement converting it in my stomach. If you want CaAKG, take CaAKG.

              • And that’s also available cheaper than Rejuvant, though not quite as cheap as the straight AKG.

                But that IS a fair point, the calcium salt might be more bio-available, worth paying a slight premium for it.

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