Diet Control of Isoleucine Increases Healthspan and Lifespan By Up to 33% in Mice

Low-protein diets promote health and longevity in diverse species. Restriction of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of these benefits in young C57BL/6J mice. Restriction of dietary isoleucine (IleR) is sufficient to promote metabolic health and is required for many benefits of a low-protein diet in C57BL/6J males. Here, we …

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Lancet Forecasts Failure of Pro-Baby Policies and Global Population Collapse

Here are the key points of a Lancet study on global fertility. Global Fertility rates will continue to collapse even if all countries adopt the current best pro-baby policies (childcare subsidies, extended parental leave, insurance coverage expansion for infertility treatment). Future fertility rates were would drop to a global TFR (total fertility rate) of 1·83 …

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UPDATE LEV Foundation Four Combined Life Extension Therapies Trying to Double Remaining Life

There is a large scale study using 1000 mice testing four major life extension therapies to see if there is an additive effect and how much additive effect there is. Preliminary data is show there can be longer lifespans with combined therapies. There have been different life extension therapies where each on there own can …

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Biggest Science and Technology Stories of 2024

Brian Wang and Randy Kirk discussed the expected biggest science and technology stories of 2024. The potentially biggest development in 2024 could be antiaging science reaching a milestone of doubling the remaining lifespan of a mouse. The Longevity Escape velocity program has take four promising anti-aging treatments and applied them in various combinations to a …

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Elon Says New Generations of Humans Are Needed for a Bright Future for Humanity

Elon Musk says clear truths that without humans there is no bright future for humanity. Nextbigfuture has written about this and looked at the detailed numbers of declining birthrates. The world population in 2200 will be about 250 million if if all countries have a total fertility rate of 1.0 or less. This is the …

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Progress to Living Molecular Cell Repair Organoids That Could Fix Neurons, Nerves and the Spinal Cord

Researchers have now taken a step toward that vision of molecular systems that repair cells inside the human body. Molecular repair built from a patient’s own cells will eventually ferret out cancer, repair injured tissue, and even remove plaque from blood vessels. They have gotten tracheal cells to form coordinated groups called organoids that can …

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Transferring and Rejuvenating Brains As a Path to a Problematic Form of Physical Immortality

Approaches to achieving radical life extension involve many scientific unknowns. There is uncertainty around whether the different forms of aging damage can be repaired. There is an approach to immortality that replaces scientific unknowns with huge technical challenges. The technically challenging approach is: 1. Rejuvenate the body by growing a body using an egg cell …

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Brain, Body and Ship of Theseus

The Ship of Theseus is a thought experiment about whether an object which has had all of its original components replaced remains the same object. Theseus, the mythical Greek founder-king of Athens, rescued the children of Athens from King Minos after slaying the minotaur and then escaped onto a ship going to Delos. Each year, …

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Progressive Brain Tissue Replacement Jean Hebert

Brain plasticity is key to making progressive brain tissue replacement work. Various brain functions can move to different parts of the brain. Jean Hebert plan would be to grow a new body with gene therapy to knockout brain development. The body would need to be kept on life support for 14-18 years until the skull …

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