Scientists from the Technical University of Munich has used a BACE inhibitor drug reduces the amount of amyloid beta in the brains of mice and restores the normal function of nerve cells and significantly improves memory. Around 50 million people worldwide suffer from dementia. To date, no effective drug is available that is able to …
Doctor Lantieri does more than mend broken bones; he tries to help his patients look as close to normal as possible. In the past, he spent long hours in the operating room, opening hundreds upon hundreds of boxes of generic plates, casts and screws, searching for the best fit for patients. Despite his painstaking work, …
The first known attempt at creating genetically modified human embryos in the United States has been carried out by a team of researchers in Portland, Oregon. Three previous reports of editing human embryos were all published by scientists in China. The US work is believed to have broken new ground both in the number of …
Duchenne muscular dystrophy (DMD) is an incurable X-linked muscle-wasting disease caused by mutations in the dystrophin gene. Gene therapy using highly functional microdystrophin genes and recombinant adeno-associated virus (rAAV) vectors is an attractive strategy to treat DMD. Here we show that locoregional and systemic delivery of a rAAV2/8 vector expressing a canine microdystrophin (cMD1) is …
The first systematic review and meta-analysis of trends in sperm count reports a significant decline in sperm concentration and total sperm count among men from Western countries. The study is published today in Human Reproduction Update, the leading journal in the fields of Reproductive Biology and Obstetrics and Gynecology. By screening 7,500 studies and conducting …
The unique swimming strategies of natural microorganisms have inspired recent development of magnetic micro/nanorobots powered by artificial helical or flexible flagella. However, as artificial nanoswimmers with unique geometries are being developed, it is critical to explore new potential modes for kinetic optimization. For example, the freestyle stroke is the most efficient of the competitive swimming …
A new way of producing the seasonal flu vaccine could speed up the process and provide better protection against infection. For decades, vaccine manufacturers have used chicken eggs to grow the flu virus strains included in the seasonal flu shot. But because these human strains frequently mutate to adapt to their new environment in eggs, …
A novel screening method developed by a team at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center — using CRISPR-Cas9 genome editing technology to test the function of thousands of tumor genes in mice — has revealed new drug targets that could potentially enhance the effectiveness of PD-1 checkpoint inhibitors, a promising new class of cancer …
Silicon Valley startup Helix will sequence your genes for $80 and lure app developers to sell you access to different parts of it. For an initial $80, Helix sequences the most important part of the genome—about 20,000 genes plus some other bits—called the exome. That information is digitized and stored by Helix, which doles out …
In 2012, among women aged 15–49 years, the estimated global prevalence of chlamydia was 4.2% (95% uncertainty interval (UI): 3.7–4.7%), gonorrhoea 0.8% (0.6–1.0%), trichomoniasis 5.0% (4.0–6.4%), and syphilis 0.5% (0.4–0.6%); among men, estimated chlamydia prevalence was 2.7% (2.0–3.6%), gonorrhoea 0.6% (0.4–0.9%), trichomoniasis 0.6% (0.4–0.8%), and syphilis 0.48% (0.3–0.7%). These figures correspond to an estimated 131 …
Traci Mann, a social and health psychologist at the University of Minnesota, says it is possible to be fat and fit. Obesity is correlated with three different things are known to be deadly and shorten lifespan: 1. being sedentary 2. having a lower income 3. not getting enough medical care Being inactive is defined as …