George Church describes going beyond cutting DNA to precise editing. 1. Phage Integrases (Protein and DNA) 2. TAL Deaminases (custom Protein) 3. Chemical Targeting (custom polymer) 4. lambda (λ)-red recombinase (Custom DNA) Beyond editing to writing large genomes DNA-based target recognition For DNA-based target recognition systems, the two major approaches, multiplex automated genome engineering (MAGE) …
Kheiron Biotech using clones thoroughbred horses and announced in 2017 that they would use CRISPR gene editing to create super horses. They plan to perform myostatin inhibition to boost the muscles in horses. They will develop horses with more muscle mass, which could run faster for longer distances and jump higher. At the end of …
There is about 70% support among Americans to use human gene editing to cure or correct diseases. The support among people in China for using human gene editing to cure disease was similar in a recent poll. The US support has increased about ten percent from a 2016 Pew Research poll. The Chinese poll of …
The chinese geneticist who has gene edited twin baby girls is reportedly missing. He Jianku caused a controversy for being the first case that we publicly know of for the genetic modification of the human germline. The Shenzhen University where he worked has denied detaining him. Reports claimed he was being kept under effective house …
I have covered the technical aspects of the gene editing of the human twin babies, but I have not had a focused look at only the ethics, compassion and noble intentions involved in this situation. I He primary motivatation for doing the work was compassion belief that he was improving the health and lives of …
The question and answer interview of He Jianku conference presentation has the most interesting parts of this debate about human gene editing of embryos. The interview starts at about 1 hour and 28 minutes of the record. The formal presentation showed that the scientist He has taken appropriate scientific care to perform the work. He …
During his presentation of the CRISPR gene editing of human embryos, the Chinese scientist said there is another woman currently pregnant with a gene edited embryo. He Jiankui is an associate professor at the Southern University of Science and Technology in Shenzhen. He did not break any international regulations but CRISPR editing of human embryos …
Any medium-sized Invitro Fertilization (IVF) clinic could utilize a CRISPR vector that can be purchased for $100 to replicate the embryo gene edit. Geneticist He Jiankui claims to have altered the genes of twin girls born this month. He Jiankui presented his work in a forum organized by the University of Hong Kong to discuss …
Three of the pioneers in the use of CRISPR-Cas9 were Emmanuelle Charpentier, Jennifer Doudna, and Feng Zhang. Doudna and Zhang helped launch Editas Medicine in 2013, but Doudna left the following year and joined Intellia Therapeutics. Intellia Therapeutics currently has a valuation of over $700 million. Editas is worth over $1.3 billion. As a chief …
CRISPR gene editing has been used to eliminate a gene called CCR5 in hopes of rendering human babies resistant to HIV, smallpox, and cholera. The Associated Press reported that He Jiankui said one couple in the trial gave birth to twin girls this month. Nature News- Genome-edited baby claim provokes international outcry The claims have …
A moth-infecting virus and nanomagnets could be used to edit defective genes that cause diseases like sickle cell, muscular dystrophy and cystic fibrosis. Above -Rice University bioengineers use a magnetic field to activate nanoparticle-attached baculoviruses in a tissue. The viruses, which normally infect alfalfa looper moths, are modified to deliver gene-editing DNA code only to …