Fast and Compact DNA Logic Circuits

DNA is a reliable biomolecule with which to build molecular computation systems. DNA logic circuits (diffusion-based) have shown good performance regarding scalability and correctness of computation. However, previous architectures of DNA logic circuits have two limitations. 1. The speed of computation is slow, often requiring hours to compute a simple function. 2. The circuits are …

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Better Gene Editing than CRISPR

George Church describes going beyond cutting DNA to precise editing. 1. Phage Integrases (Protein and DNA) 2. TAL Deaminases (custom Protein) 3. Chemical Targeting (custom polymer) 4. lambda (λ)-red recombinase (Custom DNA) Beyond editing to writing large genomes DNA-based target recognition For DNA-based target recognition systems, the two major approaches, multiplex automated genome engineering (MAGE) …

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Delivery of 45 Age Reversing Gene Therapies at Once is Under Peer Review

George Church revealed progress on aging reversal using gene therapies. They have delivered 45 gene therapies to provide aging reversal. They find the combined treatment is effective against obesity, diabetes, osteoarthritis, cardiac damage and kidney disease. At 32:00-33:30 minutes George Church specifically describes delivering 45 age reversing gene therapies to treat multiple age related diseases. …

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Woolly Mammoths would prevent the permafrost from melting and help save the planet

The goal of woolly mammoth project is to solve the permafrost climate issue. The top area of the world is covered in permafrost. The Siberian and Canadian tundra is this mass of permafrost and that permafrost is a ticking time bomb it contains within it more carbon, carbon dioxide and methane than if we burned …

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George Church talks about reversing human aging and claims they made mice live twice as long

George Church is developing better and better organs using pigs. They are working to slow or reverse the aging in the organs to be used for transplant. [about 8:40 in the video] He says the organ longvity has also been done successfully with entire mice. They have mice that live twice as long. He says …

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Programmed DNA origami nanobot kills cancer in mice

Arizona State University (ASU) scientists, in collaboration with researchers from the National Center for Nanoscience and Technology (NCNST), of the Chinese Academy of Sciences, have successfully programmed nanorobots to shrink tumors by cutting off their blood supply. Above – Nanorobots can be programmed to transport molecular payloads and cause on-site tumor blood supply blockages, which …

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DNA nanomachines cartwheels for 100X the speed of previous DNA devices

Arizona State University Professor Hao Yan and his colleagues describe an innovative DNA walker, capable of rapidly traversing a prepared track. Rather than slow, tentative steps across a surface, the new DNA acrobat cartwheels head over heels, covering ground 10 to 100 times faster than previous devices. Above -Hao Yan, director of the Biodesign Center …

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Programmed DNA nanorobots to shrink cancer tumors by cutting off their blood supply

n a major advancement in nanomedicine, Arizona State University scientists, in collaboration with researchers from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences, have successfully programmed nanorobots to shrink tumors by cutting off their blood supply. “We have developed the first fully autonomous, DNA robotic system for a very …

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Electrically controlled DNA robot arm is 100,000 times faster – millisecond moves enable molecular factories

Scientists at the Technical University of Munich (TUM) have developed a novel electric propulsion technology for nanorobots. It allows molecular machines to move a hundred thousand times faster than with the biochemical processes used to date. This makes nanobots fast enough to do assembly line work in molecular factories. The DNA nanobot is shaped like …

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Supercentenarian may have genes that protect against bad effects of aging

James Clement has collected blood, skin or saliva from supercentenarians in 14 states and seven countries over a six-year period. Lifestyle and luck, it seems, still factor heavily into why people live into their 90s and 100s. However, supercentenarians are more uniformly healthy than centenarians in their final months and years. Rather than having won …

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