Self-replicating Anti-viral Molecular Machines

Augmanity, a research company based in Rehovot, Israel, has synthesized molecular machines, made from nucleic acids, which are capable of digesting viral RNA and utilizing it to assemble additional copies of itself inside living cells. The machine’s body plan combines several parts that build upon the target RNA, assembling an immobile, DNA:RNA 4-way junction, which …

Read more

Molecular Electronics for 400 Times Faster DNA Reading by 2024

Roswell has deploying Molecular Electronics sensors on standard CMOS chip technology for a mass manufacturable and scalable platform. IMEC and Roswell have completed proof of concept work and are in the final development process. Commercial molecular biosensors will be available in 2021 for biosensing and DNA sequencing applications. Roswell will have rapid, low cost, mobile …

Read more

Commercial Molecular Electronics Chips in 2021

Roswell Biotechnologies and IMEC are partnering to develop the first molecular electronics chips for disease surveillance, precision medicine and DNA storage. They are targeting 2021 for commercial molecular electronic chips. In 2018, IMEC and Candence taped out a 3 nanometer precision test chip. IMEC also has onchip fluid sensors and tiny sensors for internet of …

Read more

2020 Emergency Coronovirus Treatment Will Start in 3 Months Versus 2 Years for SARS in 2003

In 2003 it took 20 Months for the first experimental treatment for newly identified virus but in 2020 it appears it will take 3 months for the first treatments against the Wuhan Coronavirus. China has already published the genome sequence of the Wuhan Coronavirus and experimental vaccines should be in human testing by April, 2020. …

Read more

Electric Signal Detection from Single Molecules for Molecular Electronics Revolution

The barrier to molecular electronics was the previous inability to detect the tiny electric signals from single molecules. Roswell Biotechnologies overcame that problem and integrated the solution with CMOS. This enables an interface between molecules for sensors and DNA and other biological detections with CMOS. Nanopores have existed for a long time and being able …

Read more

Eventual Exabyte DNA Storage on Roswell Molecular Electronic Chips

James Tour says that Roswell is bringing to world the $100 genome that can scale rapidly and also deliver Exabyte data storage. Paul Mola is the Founder, and CEO of Roswell Biotechnologies. Roswell could enable DNA storage technology. This would have exabyte capabilties. They have millions to billions of DNA readers on CMOS ships. They …

Read more

Reading and Writing Genomes

Reading and Writing DNA has improved 2 to 10 times faster than Moore’s Law over the last 35 years. There has been over 10 million times improvement. Molecular and cell multiplexing enable atomically precise reactions at 1 trillion reactions per droplet. George Church gave a talk about reading and writing whole genomes. George Church giving …

Read more

DNA Nanobots Used Bacteria’s Chemical Communication and This Enables Intelligent Nanobot Swarms

Bio-inspired Quorum Sensing in robots fabricated from DNA origami can communicate by transmitting and receiving diffusing chemical signals. The mechanism has features such as programmable response thresholds and quorum quenching, and is capable of being triggered by proximity of a specific target cell. Nanoscale robots with swarm intelligence could carry out tasks that have been …

Read more

Fast and Compact DNA Logic Circuits

DNA is a reliable biomolecule with which to build molecular computation systems. DNA logic circuits (diffusion-based) have shown good performance regarding scalability and correctness of computation. However, previous architectures of DNA logic circuits have two limitations. 1. The speed of computation is slow, often requiring hours to compute a simple function. 2. The circuits are …

Read more

Better Gene Editing than CRISPR

George Church describes going beyond cutting DNA to precise editing. 1. Phage Integrases (Protein and DNA) 2. TAL Deaminases (custom Protein) 3. Chemical Targeting (custom polymer) 4. lambda (λ)-red recombinase (Custom DNA) Beyond editing to writing large genomes DNA-based target recognition For DNA-based target recognition systems, the two major approaches, multiplex automated genome engineering (MAGE) …

Read more