gene therapy Archive

chinaChina leads world with 8 CRISPR trials to treat cancer and CRISPR medicine is a national priority

China has at least eight CRISPR gene therapy clinical trials to treat various forms of cancer. CRISPR is being tested as a treatment for cancers of the lung, bladder, cervix and prostate. Clinicaltrials.gov lists all of the clinical trials in …

gene therapyGene therapy getting approved to treat major diseases of muscle and blood

Researchers review the pioneering work that led the gene therapy field to its current state, describe gene-editing technologies that are expected to play a major role in the field’s future, and discuss practical challenges in getting these therapies to patients …

gene therapyBeyond Crispr -Cas9 Gene editing

Crispr/Cas9 is a riboprotein complex composed of a short strand of RNA and an efficient DNA-cutting enzyme. Crispr/Cas9 sometimes cuts in the wrong places. And it has no off-switch. Epigenetic Editing Other proteins—like ones that activate gene expression—can be combined …

gene therapyCRISPR gene therapy preserves hearing

Researchers deliver CRISPR-Cas9 directly into the inner ear hair cells of mice, preventing hearing loss in animal model of genetic progressive deafness. Above – Credit : Gao et al./Nature 2017. Confocal microscopy images of mouse cochlea; hair cells in green. …

crisprCRISPR extends lifespan of Lou Gehrigs disease mice by 25%

University of California, Berkeley scientists have for the first time used CRISPR-Cas9 gene editing to disable a defective gene that causes amyotrophic lateral sclerosis, or Lou Gehrig’s disease, in mice, extending their lifespan by 25 percent. The therapy delayed the …

gene therapyTHOR gene could be critical to curing cancer

Researchers have identified and characterized a new type of RNA protein called THOR that plays a role in cancer development — and could serve as a target for drug development. Researchers at the University of Michigan Comprehensive Cancer Center uncovered …

gene therapyGene therapy to fix failing hearts works in pigs and will be tried in humans in 2018

Scientists have been able to reverse heart failure in pigs by delivering a new gene to the heart that makes it better at pumping blood and supplying the body with oxygen. The goal is to reverse heart failure with a …

antiagingSupercentenarian may have genes that protect against bad effects of aging

James Clement has collected blood, skin or saliva from supercentenarians in 14 states and seven countries over a six-year period. Lifestyle and luck, it seems, still factor heavily into why people live into their 90s and 100s. However, supercentenarians are …

gene therapyJapanese researchers make chickens that lay egss with low cost cancer drugs

The National Institute of Advanced Industrial Science and Technology (AIST) Kansai in Osaka Prefecture has succeeded in making hens lay eggs that contain a pharmaceutical agent that can be used to treat such diseases as cancer and hepatitis, it has …