Stem Cells That Will Not Be Rejected Will Bring Mass Produced Stem Cell Treatments

CRISPR-Cas9 gene-editing system has made pluripotent stem cells that are functionally “invisible” to the immune system which will prevent rejection of stem cell transplants. Universal stem cells can be produced that will work for everyone and there will not be the need for personalized stem cells. This will bring mass production of stem cells for …

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3D Printed Bioimplants Repaired Spinal Cords and Restored Motor Function

3D printed implants are soft bridges that guide new nerve cells to grow across a tear or break in an injured spinal cord and restored movement. The work has so far shown promise in rats with severe spinal cord injury. The implants are hydrogel structures that can be rapidly 3D printed into different sizes and …

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Safer and more effective senescent cell antiaging treatment

In 2001, Aubrey de Grey and colleagues proposed ablation of senescent cells (ApoptoSENS) as the “damage-repair” strategy of choice for zombie cells. The idea was barely mentioned in the scientific literature. It was largely ignored until 2011 when a powerful proof-of-concept study showed that killing these “zombie cells” using a genetically-engineered “suicide switch” substantially rejuvenated …

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Dentists May Soon Completely Regenerate Your Teeth damaged from cavities

Paul Sharpe, a bioengineer at King’s College London, and his colleagues discovered a new way regenerate teeth in mice. They have made even more progress that edges this experimental procedure closer to human clinical trials. If the teeth regeneration treatment eventually becomes part of the dentist’s standard toolkit, then it would easily be one of …

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Longeveron developing stem cell treatments for Frailty, Alzheimers and other aging diseases

Longeveron is a life sciences company developing biological solutions for aging and aging-associated diseases through the use of Allogeneic Human Mesenchymal Stem Cells, harvested and grown at our facility in Miami, Florida, from adult-donor bone marrow. Longeveron is a privately funded startup. The Longeveron-grown Mesenchymal Stem Cells (LMSCs) are multipotent stem cells. Mesenchymal stem cells, …

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Human skeletal muscle grown from stem cells

Biomedical engineers have grown the first functioning human skeletal muscle from induced pluripotent stem cells. The advance builds on work published in 2015 when researchers at Duke University grew the first functioning human muscle tissue from cells obtained from muscle biopsies. The ability to start from cellular scratch using non-muscle tissue will allow scientists to …

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US Army improving the regrowth of bone, muscle and skin

US Army researchers are using fillers to bridge the gap in damaged bones, hoping to figuratively bridge the gap between current regenerative techniques and the ideal: people regrowing lost limbs. Stephanie Shiels with the U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas, talked about her research to develop a synthetic bone gap filler …

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Tissue engineering, replacement organs and regenerative medicine are getting friendlier regulations

The FDA (Food and Drug Administration) is rolling out a new “regulatory framework” aimed at encouraging and speeding legitimate development of regenerative therapies. The FDA intends to promote the “least burdensome” rules for companies big and small that are seeking to develop new therapies, “while ensuring patient safety.” “Our policy will allow product manufacturers that …

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Synthetic DNA coverts stem cells to heart muscle is potential tissue regeneration treatment

A newly discovered DNA-targeting molecule could inspire the first tissue regeneration therapies. The synthetic molecule can cause stem cells to transform into heart muscle cells. The scientists responsible for the new molecule believe their breakthrough could be used to turn stem cells into a variety of cell types — paving the way for tissue regeneration. …

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Oxford 3D bioprinting scaling to industrial scale tissue printing and organ printing

Scientists at the University of Oxford have developed a new method to 3D-print laboratory-grown cells to form living structures. The approach could revolutionize regenerative medicine, enabling the production of complex tissues and cartilage that would potentially support, repair or augment diseased and damaged areas of the body. While bioprinting has advanced significantly over the last …

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‘Origami organs’ can potentially regenerate tissues

Northwestern Medicine scientists and engineers have invented a range of bioactive “tissue papers” made of materials derived from organs that are thin and flexible enough to even fold into an origami bird. The new biomaterials can potentially be used to support natural hormone production in young cancer patients and aid wound healing. The tissue papers …

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