Self-healing Fabric

A DNA construct is an artificially constructed segment of nucleic acid. It can be isolated or integrated in another DNA molecule. A recombinant DNA construct is produced by laboratory methods. Polynucleotide constructs with at least one disruption or tearing responsive promoter and at least one sequence encoding a fiber-forming protein. A cell with such constructs …

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Moderna Coronavirus Vaccine Samples Shipped

Moderna shipped the first samples of messenger RNA based coronavirus vaccine to the National Institute of Allergy and Infectious Disease in Bethesda Maryland. Human clinical trials should start in 6 weeks and the results could be available in July. The Moderna vaccine will need two doses but is considered to be safe. Moderna messenger RNA …

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Messenger RNA Treatment of Viruses Like Coronavirus

There has been 20 years of work on messenger RNA treatments against viruses. Technological advancements in RNA biology, chemistry, stability, and delivery systems have accelerated the development of fully synthetic mRNA vaccines. Molecular Therapy Journal (April 2019) reviewed mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases Vaccines – Enlisting the mRNA …

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DARPA Nucleic Technology Funded to Get Virus Response to 1-60 Days

DARPA launched the Pandemic Prevention Platform program (P3) to stop pandemic treatments within 60 days of detection. The P3 program, which began in 2017, seeks to halt the spread of any infectious disease outbreak before it can escalate into a pandemic. The P3 teams are developing technologies to deliver antibodies using nucleic acid technology, and …

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2020 Emergency Coronovirus Treatment Will Start in 3 Months Versus 2 Years for SARS in 2003

In 2003 it took 20 Months for the first experimental treatment for newly identified virus but in 2020 it appears it will take 3 months for the first treatments against the Wuhan Coronavirus. China has already published the genome sequence of the Wuhan Coronavirus and experimental vaccines should be in human testing by April, 2020. …

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Electric Signal Detection from Single Molecules for Molecular Electronics Revolution

The barrier to molecular electronics was the previous inability to detect the tiny electric signals from single molecules. Roswell Biotechnologies overcame that problem and integrated the solution with CMOS. This enables an interface between molecules for sensors and DNA and other biological detections with CMOS. Nanopores have existed for a long time and being able …

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What is hot in multi-billion dollar RNAi, Gene therapy and CAR-T biotech?

There were two biotech buyouts this week. Celgene bought CAR-T player Juno Therapeutics for $9 billion and Sanofi buying blood disorder biotech Bioverativ for $11 billion. Kite Pharmaceuticals, CAR-T company, got acquired late in 2017 by Gilead for $12 billion. Both Juno and Kite had been billed as CAR-T platform play. CAR-T acquisitions provide near-term …

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RNA editing with CRISPR-Cas13

New Broad Institute ‘REPAIR’ system edits RNA, rather than DNA; has potential to treat diseases without permanently affecting the genome. The Broad Institute and MIT scientists who first harnessed CRISPR for mammalian genome editing have engineered a new molecular system for efficiently editing RNA in human cells. RNA editing, which can alter gene products without …

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Single-nucleus RNA sequencing, droplet by droplet

DroNc-Seq — a technology that merges single-nucleus RNA sequencing with microfluidics — brings new scale to gene expression studies in complex tissues. Last year Broad researchers described a single-nucleus RNA sequencing method called sNuc-Seq. This system enabled researchers to study the gene expression profiles of difficult-to-isolate cell types as well as cells from archived tissues. …

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Viome for managing your microbiome

There are approximately 40 trillion microorganisms living in your gut. They help you digest your food, produce beneficial and harmful chemicals, control infections by pathogens, regulate your immune system, and even control your emotions (ever have a gut feeling?). These microorganisms – which make up your gut microbiome – have been implicated in maintaining optimal …

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