RNA

coronavirusModerna Coronavirus Vaccine Samples Shipped

Moderna shipped the first samples of messenger RNA based coronavirus vaccine to the National Institute of Allergy and Infectious Disease in Bethesda Maryland. Human clinical trials should start in 6 weeks and the results could be available in July. The …

diseaseMessenger RNA Treatment of Viruses Like Coronavirus

There has been 20 years of work on messenger RNA treatments against viruses. Technological advancements in RNA biology, chemistry, stability, and delivery systems have accelerated the development of fully synthetic mRNA vaccines. Molecular Therapy Journal (April 2019) reviewed mRNA as …

darpaDARPA Nucleic Technology Funded to Get Virus Response to 1-60 Days

DARPA launched the Pandemic Prevention Platform program (P3) to stop pandemic treatments within 60 days of detection. The P3 program, which began in 2017, seeks to halt the spread of any infectious disease outbreak before it can escalate into a …

DNA2020 Emergency Coronovirus Treatment Will Start in 3 Months Versus 2 Years for SARS in 2003

In 2003 it took 20 Months for the first experimental treatment for newly identified virus but in 2020 it appears it will take 3 months for the first treatments against the Wuhan Coronavirus. China has already published the genome sequence …

DNAElectric Signal Detection from Single Molecules for Molecular Electronics Revolution

The barrier to molecular electronics was the previous inability to detect the tiny electric signals from single molecules. Roswell Biotechnologies overcame that problem and integrated the solution with CMOS. This enables an interface between molecules for sensors and DNA and …

businessWhat is hot in multi-billion dollar RNAi, Gene therapy and CAR-T biotech?

There were two biotech buyouts this week. Celgene bought CAR-T player Juno Therapeutics for $9 billion and Sanofi buying blood disorder biotech Bioverativ for $11 billion. Kite Pharmaceuticals, CAR-T company, got acquired late in 2017 by Gilead for $12 billion. …

crisprRNA editing with CRISPR-Cas13

New Broad Institute ‘REPAIR’ system edits RNA, rather than DNA; has potential to treat diseases without permanently affecting the genome. The Broad Institute and MIT scientists who first harnessed CRISPR for mammalian genome editing have engineered a new molecular system …

medicineSmall RNA could be breakthrough cancer treatment with a cancer kill switch

Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a …

diseaseSingle-nucleus RNA sequencing, droplet by droplet

DroNc-Seq — a technology that merges single-nucleus RNA sequencing with microfluidics — brings new scale to gene expression studies in complex tissues. Last year Broad researchers described a single-nucleus RNA sequencing method called sNuc-Seq. This system enabled researchers to study …

futureViome for managing your microbiome

There are approximately 40 trillion microorganisms living in your gut. They help you digest your food, produce beneficial and harmful chemicals, control infections by pathogens, regulate your immune system, and even control your emotions (ever have a gut feeling?). These …