Newcastle University researchers are exploring the effects of removing senescent cells that form as a result of a heart attack. Heart cells, cardiomyocytes, rarely divide it was not known how these cells could become senescent. Senescent cells are also called zombie cells. Zombie cells do not function correctly and can cause other cells around them …
In 2001, Aubrey de Grey and colleagues proposed ablation of senescent cells (ApoptoSENS) as the “damage-repair” strategy of choice for zombie cells. The idea was barely mentioned in the scientific literature. It was largely ignored until 2011 when a powerful proof-of-concept study showed that killing these “zombie cells” using a genetically-engineered “suicide switch” substantially rejuvenated …
James Peyer has been a scientist, entrepreneur, and advisor to biotechs and pharma companies, always with a specialization for developing new classes of therapeutics. James founded Apollo to support biotech entrepreneurs strategically, scientifically, and financially as they create the next generation of medicines. James Peyer received his PhD from the University of Texas Southwestern Medical …
Cellular senescence has been associated with harmful tau protein tangles that are a hallmark of 20 human brain diseases, including Alzheimer’s and traumatic brain injury. The researchers identified senescent cells in postmortem brain tissue from Alzheimer’s patients and then found them in postmortem tissue from another brain disease, progressive supranuclear palsy. Cellular senescence allows the …