Two methods of producing transgenic mice are widely used:
– transforming embryonic stem cells (ES cells) growing in tissue culture with the desired DNA;
– injecting the desired gene into the pronucleus of a fertilized mouse egg.
There are transgenic mice, goats, cows, pigs, monkeys and other animals.
Chinese scientists have successfully bred a genetically altered cow capable of producing cancer-curing proteins for human beings. Antibodies could be 50 to 100 times cheaper using the transgenic cows.
The U.S. based Business Communication Corp. has estimated the worldwide market for transgenically sourced therapies at more than $1 billion in 2008, and $18.6 billion by 2013.
Possible future: genetically engineered for endurance of an Alaskan sled dog, cheetah like speed, gorilla strength, regeneration and then add a DARPA exoskeleton for kangaroo leap and even more strength.
– agriculture, such as larger sheep that grow more wool
– medicine, such as cows that produce insulin in their milk
– industry, such as goats that produce spider silk for materials production
Researchers Develop First Transgenic Monkey Model of Huntington’s Disease: Experts See Model as Tool to Better Understand the Disease, Develop More Effective Therapies, and Lead the Way to Similar Models for Other Genetic Diseases