DARPA investigating ways to Restore Active Memory

A new DARPA program aims to investigate the role of neural “replay” in the formation and recall of memory, with the goal of helping individuals better remember specific episodic events and learned skills. The 24-month fundamental research program, Restoring Active Memory Replay or RAM Replay, is designed to develop novel and rigorous computational methods to help investigators determine not only which brain components matter in memory formation and recall but also how much they matter. To ensure real-world relevance, those assessments will be validated through performance on DoD-relevant tasks instead of conventional computer-based behavioral paradigms commonly used to assess memory in laboratory settings. New knowledge and paradigms for memory assessment and formation could translate into improved rehabilitation and recovery for injured warfighters challenged by impaired memory.

RAM (Restoring Active Memory) Replay The DARPA RAM Replay program is interested in investigating memory replay with respect to the consolidation of episodic memories and newly learned skills, and how these memories are recalled and utilized by humans during subsequent task performance

Human memory is the result of biological processes that culminate in the formation or strengthening of neural connections in the brain. Multiple mechanisms are involved in memory formation and recall, including brain networks that govern perception, attention and emotion. Through a process known as consolidation, representations of experiences are stored in long-term memory and integrated with older knowledge and memories.

Studies investigating the mechanisms of memory formation, consolidation and retrieval have suggested that memory representations in the brain are repeatedly “reactivated”—albeit often unconsciously—following initial encoding, during both wakefulness and sleep. Moreover, memory reactivation has been linked to the process of neural replay, during which patterns of neural activity reflect the patterns of activity that had occurred during initial encoding of the memory.

The engagement of the replay process, frequency of activation and the time during which replay occurs can affect subsequent performance on behavioral tasks designed to assess memory recall and performance of learned skills. Additionally, some human studies have investigated modulation of subsequent memory recall via presentation of sensory cues or transcranial stimulation during specific phases of sleep. Of particular interest, there is growing evidence that various physiological or environmental factors may affect the degree to which replay strengthens memory circuits—and the accuracy with which it does so. That suggests the possibility of developing evidence-based means of harnessing the brain’s own replay system to improve the strength and fidelity of memory.

“Unconventional memory aids are everywhere today, from simple mnemonics to sophisticated smartphone apps. But many of these techniques focus on just a few of the many aspects that influence memory,” said Sanchez. “In the long run, we hope RAM Replay will identify core memory-strengthening mechanisms and give rise to a generalizable set of solutions applicable to the challenge of memory reliability in an increasingly information-dense world. That could benefit civilians and Service members alike in areas as diverse as general education, job retraining and battlefield awareness.”


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