S4 (Acetamidoxolutamide) as it is known, is a a selective androgen receptor modulator or SARM for short. When compared to anabolic steroids, S4 is a selective androgen receptor modulator with one of the most androgenic effects. This androgenic effect is that S4 is one third of the strength of testosterone when binding to androgen receptors. S4 is fast acting and its half life is 4 hours. It may be able to reduce the size of the prostate if used at a honest dosage which is why SARMs are being looked at as replacement for Androgen Deprived Therapy or ADT for short.
The Anti-doping agency (WADA) believes that 10% of athletes are using SARMS. SARM S1 (Ostarine) is undetectable and provides performance enhancement similar to regular steroids. It also has virtually no health side effects. I think the estimate of 10% usage is low for undetectable, seemingly safe performance enhancement.
Studies have shown the ability of SARMs to increase muscle and bone mass dramatically in animals while having no adverse impact on the prostate. Phase I trials of SARMs in humans have also reported significant increases in lean muscle mass. The two most talked about SARMs among bodybuilders are SARM S-4 a.k.a. Acetamidoxolutamide and SARM S-1: a.k.a. Ostarine or MK 2866.
Selective Androgen Receptor Modulators (S.A.R.M), attach to the very same receptors that old steroids like Dianabol and testosterone would attach to, but SARMs don’t have the disadvantages and side-effects of the old school anabolic hormones. As a matter of fact, while SARMs are anabolic and improve performance, they may not even qualify as hormones. They are a completely new compound that specifically target muscle building, strength and performance without causing any of the unwanted side effects of anabolic steroids. This is a new dawn in the evolution of muscle pharmacology, and I’m sure you will enjoy learning about how SARMS can increase muscle mass, while helping you to lose bodyfat and increase athletic performance beyond what we ever thought possible.
Decades ago when Human Growth Hormone (HGH) became reliably synthesized, bodybuilders all over the world got bigger and stronger by stacking HGH with the good old Anabolic Steroids. Around 2006, Peptides entered the scene and became a better version of HGH, with less side effects and were a lot less expensive to buy. Peptides truly became Anabolics 2.0 for professional athletes from across the world, and bodybuilders got bigger than ever.
Now the age of Selective Androgen Receptor Modulators (S.A.R.M) is upon us, and many people in the fitness industry agree we are at a new stage in chemically assisted physical development, we could even call it Anabolics 3.0.
One of S4’s best attributes is the fact that it causes a drying out and hardening appearance of the muscle along with tightening of the skin. It binds extremely well to your androgen muscle tissue receptors (AR), leading to more lean body mass which is why you as a bodybuilder would want to learn about it the first place.
Another great attribute is that S4 promotes dramatic fat loss by binding to your androgen receptors causing your fat to be oxidized. Part of the reason why one dries out so well while using it is because since it is not an androgen it does not aromatize. This means that S4 cannot turn into any of the nasty estrogenic hormones that cause problems, the way anabolic steroids do.
An oral dose of between 30mg to 50mg per day is what is needed to see results.
Unfortunately, S4 use is not without dangers. S4 can turn into the metabolite known as “M1”, a compound which could possibly cause a change in one’s own DNA. How does the S4 metabolite M1 affect the user? M1 can bind to the ocular receptor in your eye and it can bind to receptors in your heart the same way. This can have an averse impact on your vision, heart and other organs. This is why it is common to hear feedback from S4 testing stating that a subject’s vision became all one color at night. We can speculate that so long as one is careful and does not abuse S4, there is likely no real long term serious threat. Short term usage is probably acceptable, but long term use of S4 is not recommended until further clinical trials are performed.