29 baby mice were produced out of 210 attempts at breeding from two female mice.
Researchers at the Chinese Academy of Sciences were able to produce healthy mice with two mothers that went on to have normal offspring of their own. Mice from two dads were also born but only survived for a couple of days.
In a different experiment, there were attempts to breed mice from poop. However, they were only able to get fertilized cells from the poop and get them to split once into a two-cell embryo. There was two much damage from the bile and toxins.
The work shows how far they can push gene therapy and stem cell manipulation.
β’ Haploid ESCs display PGC-like methylation profiles following in vitro cultivation
β’ Parthenogenetic and androgenetic haploid ESCs show different demethylation dynamics
β’ phESCs carrying 3 deleted imprinted regions support normal growth of bimaternal mice
β’ ahESCs carrying 7 deleted imprinted regions produce live full-term bipaternal mice
Summary
Unisexual reproduction is widespread among lower vertebrates, but not in mammals. Deletion of the H19 imprinted region in immature oocytes produced bimaternal mice with defective growth; however, bipaternal reproduction has not been previously achieved in mammals. We found that cultured parthenogenetic and androgenetic haploid embryonic stem cells (haESCs) display DNA hypomethylation resembling that of primordial germ cells. Through MII oocyte injection or sperm coinjection with hypomethylated haploid ESCs carrying specific imprinted region deletions, we obtained live bimaternal and bipaternal mice. Deletion of 3 imprinted regions in parthenogenetic haploid ESCs restored normal growth of fertile bimaternal mice, whereas deletion of 7 imprinted regions in androgenetic haploid ESCs enabled production of live bipaternal mice that died shortly after birth. Phenotypic analyses of organ and body size of these mice support the genetic conflict theory of genomic imprinting. Taken together, our results highlight the factors necessary for crossing same-sex reproduction barriers in mammals.
Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.
Known for identifying cutting edge technologies, he is currently a Co-Founder of a startup and fundraiser for high potential early-stage companies. He is the Head of Research for Allocations for deep technology investments and an Angel Investor at Space Angels.
A frequent speaker at corporations, he has been a TEDx speaker, a Singularity University speaker and guest at numerous interviews for radio and podcasts.Β He is open to public speaking and advising engagements.
Next trick imprinting the genetic material from a male onto a egg.
Great news for the lesbian community. They can now have offspring with 2 moms.
Next trick imprinting the genetic material from a male onto a egg.
Great news for the lesbian community. They can now have offspring with 2 moms.
No such thing as two much
No such thing as two much
Maybe people born of poop become politicians of the party we don’t like? π
there were attempts to breed mice from poop” Is poop some kind of acronym here – or are they going full Saruman and breeding them “from the heat and slimes of the earth”?
Maybe people born of poop become politicians of the party we don’t like? π
there were attempts to breed mice from poop””Is poop some kind of acronym here – or are they going full Saruman and breeding them “”””from the heat and slimes of the earth””””?”””
You mean the democraps and the repooplicans?
You mean the democraps and the repooplicans?
Of the offspring of the two female mice that survived how many were male? None I presume.
Of the offspring of the two female mice that survived how many were male? None I presume.
Bill Clinton in his most recent South Park appearance had it right.
Considering the “damage from the bile and toxins”, not an acronym.
Bill Clinton in his most recent South Park appearance had it right.
Considering the damage from the bile and toxins”””” not an acronym.”””
Reproduction has been working quite well” Except when it doesn’t.
Reproduction has been working quite well””Except when it doesn’t.”””
Reproduction has been working quite well” Except when it doesn’t.
Reproduction has been working quite well””Except when it doesn’t.”””
Bill Clinton in his most recent South Park appearance had it right.
Bill Clinton in his most recent South Park appearance had it right.
Considering the “damage from the bile and toxins”, not an acronym.
Considering the damage from the bile and toxins”””” not an acronym.”””
“Reproduction has been working quite well”
Except when it doesn’t.
Of the offspring of the two female mice that survived how many were male? None I presume.
Of the offspring of the two female mice that survived how many were male? None I presume.
You mean the democraps and the repooplicans?
You mean the democraps and the repooplicans?
Bill Clinton in his most recent South Park appearance had it right.
Considering the “damage from the bile and toxins”, not an acronym.
Maybe people born of poop become politicians of the party we don’t like? π
Maybe people born of poop become politicians of the party we don’t like? π
there were attempts to breed mice from poop” Is poop some kind of acronym here – or are they going full Saruman and breeding them “from the heat and slimes of the earth”?
there were attempts to breed mice from poop””Is poop some kind of acronym here – or are they going full Saruman and breeding them “”””from the heat and slimes of the earth””””?”””
Of the offspring of the two female mice that survived how many were male? None I presume.
No such thing as two much
No such thing as two much
You mean the democraps and the repooplicans?
Maybe people born of poop become politicians of the party we don’t like? π
“there were attempts to breed mice from poop”
Is poop some kind of acronym here – or are they going full Saruman and breeding them “from the heat and slimes of the earth”?
Next trick imprinting the genetic material from a male onto a egg.
Next trick imprinting the genetic material from a male onto a egg.
Great news for the lesbian community. They can now have offspring with 2 moms.
Great news for the lesbian community. They can now have offspring with 2 moms.
No such thing as two much
Next trick imprinting the genetic material from a male onto a egg.
Great news for the lesbian community. They can now have offspring with 2 moms.