New Gene Editing Tool for Millions of Edits

There is a new gene-editing tool called Retron Library Recombineering (RLR) that makes this task easier that has been developed by George Church and his team. RLR generates up to millions of mutations simultaneously, and “barcodes” mutant cells so that the entire pool can be screened at once, enabling massive amounts of data to be …

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BioRevolution Could Reach $4 Trillion Per Year in the 2030s

McKinsey forecasts a biotech revolution will improve human health and transform agriculture and food, consumer products and services, and materials and energy production. Advances in biological sciences accelerated by developments in computing, data analytics, machine learning, AI, and biological engineering. They group innovations into four arenas: biomolecules, biosystems, biomachine interfaces, and biocomputing. Biomolecules are related …

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Re-activating Youth Boosting Genes to Reverse Human Aging By 2030

As you get older, key genes that maintain life are no longer activated. George Church is focused on turning youth-boosting genes back on. His company, Rejuvenate Bio, has begun clinical trials in old dogs. This will help us determine which ages of humans would best benefit. George believes they will be able to help people …

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Kriya Therapeutics Gets $80 Million for Gene Therapy Vs Obesity and Diabetes

Kriya Therapeutics announced today that it has raised $80.5 million in a Series A financing to fund the development of transformative gene therapies for highly prevalent serious diseases. Kriya was formed in the fourth quarter of 2019 and has an industry-leading gene therapy team that includes former senior leadership from Spark Therapeutics, AveXis, Sangamo Therapeutics, …

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Gene Therapy Doubled Strength and Reduces Fat

Gene therapy helped build significant muscle mass quickly and reduced the severity of osteoarthritis in the mice, even though they didn’t exercise more. The therapy also staved off obesity, even when the mice ate an extremely high-fat diet. Science – Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity …

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George Church and Rejuvenate Bio’s Combination Gene Therapy Paper

Nextbigfuture has been eagerly awaiting the publication of the research paper on the scientific results of the combination gene therapy experiments by George Church and the team at Rejuvenate Bio. There was a video over one year ago where George Church mentioned being able to double the lifespan of mice. This would be three times …

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Stem Cell Therapies are Closer to Not Needing Anti-Rejection Drugs

Universal stem cells that would not need anti-rejection drugs would be transformative for regenerative medicine. New research by AgeX and Juvenescence brings us much closer to Universal stem cells. They are getting success modifying the immune signaling molecule that protects the fetus from rejection during pregnancy. Nextbigfuture interviewed Greg Bailey and Nafees Malik. Gregory Bailey, …

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High Resolution Imaging Screens Thousands of Genes in a Few Days

Researchers at the Broad Institute of MIT and Harvard and MIT have developed a new method that combines large-scale pooled genetic screens with image-based analysis of cellular behavior. The approach, called optical pooled screens, allows researchers to examine how genes affect complex cellular processes with spatial and temporal resolution, in ways that other pooled screens …

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Prime Genome Editing System Could Accelerate Disease Cures

A new type of gene editing enables more precise editing than CRISPR. Prime editing combines two key proteins and a new RNA to make targeted insertions, deletions, and all possible single-letter changes in the DNA of human cells. Prime Editing is capable of directly editing human cells in a precise, efficient, and highly versatile fashion. …

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