Here is more on the 454 method The analysis of some 25 million bases of DNA sequence using 454’s “sequencing by synthesis” nanotechnology approach allowed a team of more than 50 researchers to assemble almost the complete genome of Mycoplasma genitalium – some 580,000 nucleotides, or bases – with greater than 99 percent accuracy in about 4 hours.
The polony sequencing approach of George Church seems to be as fast or faster but cheaper
Nanopore DNA sequencing approach
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