Moderna Coronavirus Vaccine Samples Shipped

Moderna shipped the first samples of messenger RNA based coronavirus vaccine to the National Institute of Allergy and Infectious Disease in Bethesda Maryland. Human clinical trials should start in 6 weeks and the results could be available in July.

The Moderna vaccine will need two doses but is considered to be safe. Moderna messenger RNA system has had 6 successful phase 1 clinical trials for other diseases. It is hoped that two doses would protect an adult against a coronavirus infection.

The Moderna Vaccine would have to prove effective and then get scaled for distribution in 2021.

They released the first batch of mRNA-1273, the Company’s vaccine against the novel coronavirus, for human use. Vials of mRNA-1273 have been shipped to the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institutes of Health (NIH) to be used in the planned Phase 1 study in the U.S.

mRNA-1273 is an mRNA vaccine against the novel coronavirus encoding for a prefusion stabilized form of the Spike (S) protein, which was selected by Moderna in collaboration with investigators at the NIAID Vaccine Research Center (VRC). Manufacture of this batch was funded by the Coalition for Epidemic Preparedness Innovations (CEPI).

The collaboration across Moderna, with NIAID, and with CEPI has allowed us to deliver a clinical batch in 42 days from sequence identification,” said Juan Andres, Chief Technical Operations and Quality Officer at Moderna. “This would not have been possible without our Norwood manufacturing site, which uses leading-edge technology to enable flexible operations and ensure high quality standards are met for clinical-grade material.”

The Company’s manufacturing plant in Norwood, MA manufactures Moderna’s portfolio of mRNA development candidates, including vaccines and therapeutics. To date, the Company has produced and released more than 100 batches from its Norwood site for human clinical trials. mRNA-1273 is part of the Company’s core prophylactic vaccines modality, which has had six positive Phase 1 clinical readouts across six different vaccines over the past four years.

About mRNA-1273

mRNA-1273 is an mRNA vaccine against the novel coronavirus encoding for a prefusion stabilized form of the Spike (S) protein, which was designed by Moderna in collaboration with NIAID. The S protein complex is necessary for membrane fusion and host cell infection and has been the target of vaccines against the coronaviruses responsible for Middle Eastern Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS).

Moderna has demonstrated positive Phase 1 data readouts for six prophylactic vaccines (H10N8, H7N9, RSV, chikungunya virus, hMPV/PIV3 and CMV). Moderna’s CMV vaccine is currently in a Phase 2 dose-selection study. Moderna’s investigational Zika vaccine (mRNA-1893), currently in a Phase 1 study, was granted FDA Fast Track designation.

About Coronavirus

Coronaviruses are a family of viruses that can lead to respiratory illness, including MERS and SARS. Coronaviruses are transmitted between animals and people and can evolve into strains not previously identified in humans. On January 7, 2020, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, Hubei Province of China.

18 thoughts on “Moderna Coronavirus Vaccine Samples Shipped”

  1. As CA’s minor measles outbreak two years ago showed… many anti-vaxxers live in deep blue areas of blue states.

    It takes a certain despicable cretin to hope that this virus infects their political adversaries. You sir are that cretin.

  2. They “work” in the sense that they convey the social message “stay away from people and wash your hands”.

    So altering outcomes by a factor slightly larger than zero. However the masks are NOT worth waiting in a long line to get (Korea) and they won’t protect you if you feel the need to manhandle someone (aka China police).

  3. anti-vaxx and flat-earth believers are about the same. Nothing you can say, do, show or any evidence of any kind will change their believe on the subject.

  4. I would suggest that you bend over as far as possible and kiss your a$$ goodbye.

    But, if your in good health and under 60 you “should” be able to survive.

  5. Are they using a live attenuated virus of some kind as a delivery vehicle for the vaccine? That’s a lot less impressive; multiplying RNA is much easier than growing large numbers of virions.

  6. There are no monopolies on this kind of stupid. It becomes very hard to repudiate something you preached, got all your friend to believe, rejected and condemned people, got others in your group to reject people because they did not believe…
    Ego, shame, potential rejection and loneliness, it is all in play.

  7. Sorry then yes I agree with you.
    I take mask alone to mean surgical mask.
    Respirator mask is a different meaning.
    Shave that beard.

  8. I’ll play along.
    No one is going to force it on you. So, odds are, if you are 39 or younger, you will just get a cold.
    If you are 90…good bye.
    Then again, you probably don’t believe in science like nutrition science and eat a bag of pork rinds and drink a six-pack of beer every day and are 350 lb with several health conditions. So you can flip a coin.

    Better dust off the treadmill, erg, exercise bike or whatever you bought 10 years ago after a new years resolution…or someone smart gave you, concerned about your imminent demise.

  9. The P95 masks that fit to your face work. They will stop the aerosol spray of a sneeze. That is why the health workers are using them.
    The simple square of fine fabric is useless because the air comes in from the sides and all around.
    I think they are telling everyone masks don’t work, rather than which ones work, to make sure there are enough for health workers.
    Price is going sky high on these things as people hoard them.
    We need to get some factories making these things immediately. The Chinese and others are using them up fast, and there won’t be enough if it hits here.
    Well the big respirator type masks don’t look high. But they are a pain to wear for any length of time. You will look ridiculous and no one can hear what you are saying.
    Big profiteering on eBay:
    This is interesting:

  10. I am concerned about the spread in Iran. Only women seem to be wearing masks. If you have a beard, as most of these men do, the mask is going to be near useless. In the area of China hit, very few men have beards.

  11. That’s a neat trick. Making your cells produce the spike protein from mRNA (if I understand correctly), teaching your immune system to make the antibodies.

    How does the mRNA get into the cell to do it’s dirty work?

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