Definitive Evidence that Vitamin D Halves COVID Deaths and Reduces ICU Admissions

Various studies prove an association between severe vitamin D deficiency and bad COVID-19 outcomes. Other studies show Vitamin D plays a crucial role in immune function and inflammation. Recent data suggests a protective role of vitamin D against bad outcomes. Vitamin D (5000 IU Vitamin D3 daily for 2 weeks) halves the risk of COVID death and greatly reduces ICU admission. There are some other protocols tested in Spain which greatly improve results for those who are hospitalized.

Pharmaceuticals Journal – Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis

There are still over 11000 global COVID deaths every week and the US is still reporting over 3000 COVID deaths each week.

Take 5000 IO Vitamin D3 Supplement for 2 Weeks

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

A 5000 IU daily oral vitamin D3 supplementation for 2 weeks reduces the time to recovery for cough and gustatory sensory loss among patients with sub-optimal vitamin D status and mild to moderate COVID-19 symptoms. The use of 5000 IU vitamin D3 as an adjuvant therapy for COVID-19 patients with suboptimal vitamin D status, even for a short duration, is recommended.

Spain has an in hospital treatment protocol that gets good results.

Nutraceutical approach

* Promote the immune response and reduce the inflammatory response
* Anti-inflammatory, antioxidant, and immunomodulatory properties of vitamin D
* Immune optimisation and immune boosting
* Vitamin D maintains pulmonary barrier function
* Determines the production of antimicrobial peptides
* Enhances neutrophil activity
* Shifts the adaptive immune response to a more T helper cell-2 type

Anti-inflammatory effects of vitamin D

* Reduces the production of pro-inflammatory cytokines, such as IL-6, IL-8, IL-9, IL-12, TNF alfa, IFN gamma
* Increases production of anti-inflammatory cytokines, such as IL-4, IL-5, IL-10
* Patients with a low baseline vitamin D get more benefits.
* Reduce risk of asthma exacerbations

Prevents acute respiratory infections, and reducing their complications

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials

The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups (RR = 0.46)

Conclusively, COVID-19 patients supplemented with vitamin D, fewer rates of ICU admission, mortality events, and RT-PCR positivity.

Meta-analysis and trial sequential analysis (TSA).

Better explain the strength of association.

Protective role of vitamin D supplementation, and risk of mortality / admission to intensive care units.

Researchers searched four databases on 20 September 2022.

Screened the randomized clinical trials (RCTs)

Assessed the risk of bias. How to adjust thresholds for significance in randomised clinical trials when the required sample size has not been reached.

The pre-specified outcomes of interest.

Mortality and ICU admission.

78 bibliographic citations.

Five RCTs were suitable for their analysis.


Vitamin D administration results in a decreased [halved] risk of death, 0.49

Vitamin D administration results in a decreased risk of ICU admission, 0.28

Protective role of vitamin D and ICU admission

The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive.

21 thoughts on “Definitive Evidence that Vitamin D Halves COVID Deaths and Reduces ICU Admissions”

  1. Robin Whittle at discusses in several articles the IMMUNE system – not calcium-bone system – issues with D3. 25-hydroxyvitamin D should be 50 to 80 ng/ml for immune efficacy, not the 20-30 per the age-old/obsolete perspective of ‘calciumists’ …. times change, broader perspectives get recognized.

  2. This is confusing in that Vitamin D is beneficial for those deficient in the vitamin with respect to COVID, but does taking it when not deficient beneficial? I am not sure. From the Merck Manual taking 1250 mg or more for a couple of months may lead to hypercalcemia. So is it beneficial as a prophylactic for those not deficient?

  3. I left out the fact vitamin D3 provides direct renin antagonism, which was one of original reasons for proposing it. Elevated renin activity is a risk factor in Covid.

    And, FYI, vitamin K is a vitamin D3 antagonist. Calcium deposition in arteries typically occurs above 10,000 IU daily. If calcification occurs at lower doses, more than just that is involved. Check your parathyroid function, uremia and essential fatty acid balance. Omega-3 EPA, for instance, upregulates klotho and vascular repair.

    H2S also prevents calcification of vascular smooth muscle cells, especially in models of high D3 – so this is yet another sulfur balance problem that crosses over into D3.

    Obesity would tend to drive calcification through PVAT dysfunction, which turns the microvascular environment oxidative and diminishes healthy NO and H2S production. Also produces harmful leptin resistance.

  4. From the start of the pandemic, people noticed that there was a strong correlation between low Vitamin D and death. Vitamin D is cheap and safe. We should have been taking it from the start.

    • After being tested and found to be extremely low in D3 (10 years ago) I started taking 4000 IU a day. It is cheap and takes less than a minute a day.

  5. Vitamin D is great for a lot of reasons, but one word of caution!
    You MUST take it together with K2 or calcium will deposit in your arteries and kidneys rather than your bones!
    Also Zinc and Selenium can help against COVID.

  6. We never took the jab. Just increased our Vitamin D intake, exercised and generally kept well. Caught COVID and was sick for a couple of days. I’ve had colds and flus which were 10x worse than COVID.

    • You, sir, are not what happens to everyone. You cannot extrapolate to the masses from your one experience. Some of my relatives got Covid, and most shrugged it off, but two elderly relatives died.

  7. This isn’t a surprise and was predicted by plenty of knowledgable people like myself at the pandemic outset. Vitamin D3 stimulates regulatory T-cells (Tregs) which dampens IL-17 and stokes IL-10 and IgA production (required for immediate mucosal immunity for initial viral contact). Yes, you also get antimicrobial/antiviral cathelicidin and defensins – but also, D3 is a prohormone. D3 is also a major stimulant of H2S synthesis via vascular enzymes like CBS, restoring reductive balance in oxidative disorders (unless it’s grossly overexpressed, of course).

    Coupled with injected methyl-b12 (methylcobalamin), D3 should tackle the majority of Covid symptoms, short and long – a point I made to Louisiana’s public health department in March of 2020. The TMPRSS2 enzyme required by ODG Covid and many other variants rises in response to low H2S or high androgen levels. I learned about the B12 viral suppression angle from 1990s work on Bell’s Palsy. The D3 antiviral/self-tolerance work was clear twenty years ago in M.S.

    More widely known: low D3 among emergency room admissions correlates to higher mortality almost proportionate to the deficiency. So doctors naturally thought, supplement admissions with Vit. D. But that didn’t work. So they said, oh, use D3, the active form. That didn’t budge mortality numbers either – at least until you got a year out, then the curve starts bending. I suspect the problem relates more broadly to 1-carbon metabolism, which regulates genetic methylation and homocysteine (always rising in Covid when H2S-producing ACE2 cells are knocked out).

    Vitamin D3 on its own simply won’t correct aberrant sulfur metabolism quickly – how could it? There’s a whole cluster of factors you need in the gut working together for proper absorption: zinc, magnesium, calcium, phosphorus, estrogen (for women), folate and inulin. You can’t even hold on to magnesium without cathelicidin and EGFR signaling – for which you need D3 and healthy flora. But if you had that, you wouldn’t need the D3, would you? Most doctors aren’t taught about *functional* deficiency. Test numbers can look fine but knock out one leg and the pedestal tilts – and righting gets quite complex.

    So if you tackle both D3 and methyl-B12 – and I would recommend adding injected leucovorin to tackle the cortisol/HPA axis problem – you should get the best results with Covid, which is now broadly recognized as pernicious anemia (welcome to the party, pals; maybe you’ll recognize the obvious gut dysbiosis in long Covid sometime before 2030). This, by the way, is the approach I took almost twenty years ago for treating my mercury poisoning, dysbiosis, malnutrition, autoimmunity, reawakened viral infections and neuropathy.

    That’s why I know Covid well – both Hg2+ and Covid wreck cysteine metabolism which then damages molecular chaperone systems like HSP90/70. Sulforaphane – another life extension compound – helps too. Don’t believe me? Browse Pubmed. Hit your doctor in the head with it until it sinks in. (Now, getting your doctor to actually *apply* that science is another matter… His hedge fund employer may fire him.)

    Oh, low-dose naltrexone (LDN) should work well too against Covid – along with dozens of different cancers, chronic pain conditions and autoimmunity – but then LDN is a couple hundred bucks a year vs. thousands for opiates in pain treatment, hundreds of thousands for complex antibody drugs to treat autoimmunity and millions for cancer biologics, chemo and radiation.

    Two-thirds of the ad buys on the news come from pharmaceuticals. Understand now why the “news” doesn’t tell you anything about medicine – *especially* how simple Covid is to treat. Cheap, public domain chemicals don’t generate ad buys, executive bonuses, stock buybacks, campaign donations or “consulting” fees for the spouses of judges, congressmen and Supreme Court Justices.

    Also of interest: the butyrate produced by intestinal flora. These flora come unbalanced when Covid whacks ACE2 sentinel cells in the gut lining. Bacteria grow into the gut lining, resulting in endotoxemia and inflammation, triggering dysbiosis. Short-chain fatty acid production of butyrate and acetate from prebiotic fiber drops as the healthy flora yield to unhealthy flora. Butyrate stokes TRegs while broadly regulating epigenetics (via HDAC inhibitor and DNMTs), H2S production, appetite regulation, etc… Butyrate has similar broad application to LDN. But then, do you want butyrate and LDN for a few hundred bucks or tens of thousands of dollars of gliptins?

    Also of interest here: Vitamin D3 is integral to a klotho/FGF-23/parathyroid/phosphorus regulatory longevity pathway. (H2S/AMPK are also major life extension pathways – and the last gas pedal you want to hit if you have ALS or osteoarthritis. Not all of these pathways pull in the same beneficial direction in ever cell type, under every condition.)

    Also important for vented Covid patients is UV light exposure which reduces ventilator delirium – which we knew before Covid hit, yet still won’t do anything about. I cannot stress enough that UV light does so much more than just work on D3. It is crucial to have UV exposure when you are hospitalized, especially with sepsis. Fasting and UV light saved a surprising number of wounded, septic Civil War soldiers left to die in the fields. If only hospitals could bill for that kind of neglect, perhaps more of us would survive sepsis.

    FYI, handle ivermectin with great caution. It’s a deworming agent and nations deworming themselves with it are in store for a pandemic of modern diseases. You can’t get multiple sclerosis and almost certainly long Covid until you are dewormed (and get Epstein-Barr/mono). There has never been a single recorded case of M.S. in a helminth-replete population. The relationship between M.S. incidence and deworming is *perfectly* linear. Deworming also causes or amplifies Crohn’s, colon cancer, atherosclerosis, Parkinson’s, Alzheimer’s, heart failure, anorexia and a host of other autoimmune, neuroinflammatory and other disorders of modern life. Among other things, having worms yield Tregs, (anti-allergy) IgG4, cholinergic tone, better angiogenesis and tissue repair and… wait for it…

    Type I interferon responses in your mucosa.

    Yes, that’s right. If you have your worm population intact – and that includes your gut steadily being hit with a low level of worm eggs from the outside environment – then you have normally functioning immune responses against respiratory RNA viruses. You briefly get, but don’t get “sick” from RSV, influenza A and presumably Covid – the later of which has hardly made a ripple in helminth-replete nations.

    I’m not recommending malaria or schistosomiasis to prevent Covid, but the same way you don’t wage jihad on the lactobacillus in cheese because your cousin died of bacterial pneumonia, you shouldn’t ditch hookworms and other symbionts that have been in our ancestors’ bodies for millions of years. We get screwed up once these multicellular commensal organisms are gone, triggering an epidemic of slowly burgeoning autoimmune and neurodegenerative diseases – including problems you don’t think of like autism, obesity, diabetes and baldness. Influenza alone is a major driver of schizophrenia and autism in the modern world. And a good chunk of Parkinson’s and ALS stems from infections and autoimmune responses that probably don’t occur in helminth-colonized bodies.

    This broad pandemic gets worse slowly from one generation to the next because deworming contributes to dysbiosis in the bacterial, viral and fungal populations of the gut, which we mostly inherit from our mother – which is further degraded across generations by processed food and antibiotics. (UV light proves to be vital in gut health too.)

    As always, medicine is more complicated. This post is not meant to provide specific medical advice, which must always be tailored to a particular patient, but rather to enlighten you about the horrible burden of modern diseases currently ravaging our societies. This war of enclosure on modern ecology is snowballing, particularly when you consider the broader pollution issues like microplastics. Covid was a love-tap and look how badly we flunked the test. Much worse is possible and the risks are piling up.

    • There was a nice trial a couple of years ago where Turkish physicians used an i.v. dose of 300,000 units of Vit. D in emergency patients (hospitalised) with favourable outcomes. Other studies spread that cumulative dose over a few days, but with large initial doses.
      These studies are collected by in their Vit. D section.
      It is a bit difficult clinically to get Zinc levels -in 40 years I never ordered a zinc level, although I did see one reported alongside a Selenium level in a Naturopath’s patient.
      I am hoping that the pfarma pfraud which we are currently seeing will awake allopathic medicine to the factors you have detailed.

    • Is there anyway you could reach out to me? The Drs are just letting me die I feel like… My email is, if you’re willing!

      My entire endocrine system is messed up…my body is all messed up, my cortisol and blood pressure are super low, hypopituitarism, hypoparathyroidism, tumors on my pituitary gland, liver, inside uterus, no detectable level of estrogen, low vitamin d even with 3700 IU of D3 daily, bloodwork is ALL out of whack…so much more to list! Sigh.

  8. The evidence for efficacy of D3, zinc, and Ivermectin was definitive two years ago. Cognoscenti have been taking them all along.

    • Yeah, I started D-3 almost as soon as the news about Covid surfaced. Zinc, too. This stuff wasn’t a secret, it’s been known for years that the FDA’s recommended daily allowance was too low. And probably as a result, despite being in my 60’s with a history of respiratory problems due to cancer/chemo damaged lungs, I was over Covid in a couple days.

      They set the daily allowance for vitamins at the level necessary to prevent acute deficiency diseases like rickets and scurvy, not the level that’s optimum for health.

      Mind you, it’s a preventative, not a treatment. You want the benefit, you have to have been already taking it when you’re exposed to the virus. Popping some D-3 tabs and zinc after you get sick is too late.

    • With anything there is the issue of how much is too much.
      From what I’ve heard a *deficiency* in vitamin D weakens the immune system. Anyone living where cold weather means it is impractical to expose your skin to solar UV, should be taking vitamin D supplements anyway. But there has to be a too much level.
      Zinc is probably similar.
      Ivermectin was already well known to be good for treating infestations with a various sorts of parasitic worms. I had heard that the cases where Ivermectin seemed to do some good were in areas where people with COVID were also likely have worms & any benefit might have been just from killing the worms

      • Look at or for a nicely curated collection of recent and current research.
        Because the diagnostic criteria for Covid are so corrupt, particularly sing PCR with Ct40, it is very difficult to assess any of the studies.
        If you look at the graphic in Brian’s article with 930 million cases and 9 million deaths you would conclude that Covid was 1% fatal. Most population studies now show at least 90% of the population with antibodies, with real mortality much lower, maybe 0.1%; age dependent, with very few deaths among the healthy except, as the article shows, the Vit.D deficient.

        • one million out of 330 million died of Covid in America. That’s about 0.3%. But of course, you will say it’s all fake. Covid affected people differently. For people 70 and over, Covid infection death rate was about 10%.

  9. It’s good to see empirical evidence of it. In the UK, South Asians were really over represented in the deaths. Dark country + dark skin = vitamin d deficiency, so people assumed that was the reason.

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