Blood test can predict with 90% accuracy the risk of Alzheimer’s onset in the next three years

A blood test can accurately predict the onset of Alzheimer’s disease, according to US researchers.

They showed that testing levels of 10 fats in the blood could predict – with 90% accuracy – the risk of the disease coming on in the next three years. The 10 markers of Alzheimer’s could predict who was likely to enter mental decline in the following years.

The full power of the test has not been investigated either. So far they know a diagnosis of dementia can be predicted three years ahead of time, but the researchers are now investigating whether the test works even earlier.

Nature Medicine – Plasma phospholipids identify antecedent memory impairment in older adults

Alzheimer’s disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050. There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progressed to produce evident memory loss and functional decline. Biomarkers of preclinical disease will be critical to the development of disease-modifying or even preventative therapies. Unfortunately, current biomarkers for early disease, including cerebrospinal fluid tau and amyloid-β levels, structural and functional magnetic resonance imaging and the recent use of brain amyloid imaging or inflammaging, are limited because they are either invasive, time-consuming or expensive. Blood-based biomarkers may be a more attractive option, but none can currently detect preclinical Alzheimer’s disease with the required sensitivity and specificity. Herein, we describe our lipidomic approach to detecting preclinical Alzheimer’s disease in a group of cognitively normal older adults. We discovered and validated a set of ten lipids from peripheral blood that predicted phenoconversion to either amnestic mild cognitive impairment or Alzheimer’s disease within a 2–3 year timeframe with over 90% accuracy. This biomarker panel, reflecting cell membrane integrity, may be sensitive to early neurodegeneration of preclinical Alzheimer’s disease.

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