Stephane Bancel CEO, Moderna Theraputics
Stéphane Bancel joined Moderna Therapeutics in 2011 after learning of their novel platform developing messenger RNA therapeutics
What if mRNA could b e a digital medicine
mRNA as software or your cellular machinery
Human body as a protein factory
Protein based drugs have been slow and difficult
Gene therapy also is taking a long time to get developed and approved
could you go in between ?
It was thought that mRNA would last only minutes and cause flu like symptoms
But make a human a protein factory inside your cells
mRNA can be combined to do cocktails of antibodies
6 months from idea to a drug ready to go
mRNA is like software
24-120 months downto 6-24 months
Want to learn 10X faster
Build the 1st digital biotech company, invest IT and automation
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Core “Expression” Platform: messenger RNA Therapeutics
Modified messenger RNA (mRNA) Therapeutics
mRNA drugs drive therapeutic benefit by virtue of the proteins they encode. Because of mRNA’s ability to direct transient, dose-dependent intracellular expression of protein, we are witnessing the creation of a series of new drug modalities:
- Secreted proteins
- Combination therapy
- Un-druggable intracellular pathways
- Regenerative medicine
Through these modalities, our mRNA Therapeutics
We have invested to create a new scale of drug discovery and development at Moderna. Our mRNA drugs can be made and dosed with unprecedented precision and speed, vastly reducing the time and costs of traditional drug development.
As a platform, mRNA Therapeutics
- Native, wild-type proteins and antibodies are produced and studied in vivo, negating the need for extensive in vitro biology research;
- mRNA drug candidates can be developed and tested in a matter of weeks, enabling an expedited process from concept to first-in-human studies;
- All mRNA Therapeutics
are made using the same reagents in the same cell-free production process, enabling rapid, cost-effective GMP manufacturing. This is possible due to the similarities among all messenger RNAs, which vary only in their RNA sequence.
In preclinical, in vivo, proof-of-concept studies, mRNA Therapeutics
Manufacturing and Automation
At Moderna, we are speeding the development of a series of new drug modalities, each with the potential to generate its own product development opportunities in many therapeutic areas. We are committed to developing the broadest possible array of drugs imaginable and to developing them simultaneously — to deliver on the promise of messenger RNA (mRNA) science for patients as quickly as possible.
We are investing in the build-out of highly automated production and manufacturing capabilities to power our discovery and development efforts at a scale and speed that is truly differentiating. Deploying the most advanced robotics technology, we are automating every step of the process — from filtering and purification, to the creation of each mRNA construct, to the rapid production and manufacture of those constructs for discovery and development.
In addition, we have pioneered a first-in-class drug discovery software solution which enables scientists working with Moderna to design, order, and optimize a drug in a matter of minutes, for delivery in weeks, from a cloud-based portal.
With this technology, we can achieve:
High levels of purification;
Unprecedented scale, with the capacity to produce dozens to hundreds of unique mRNA constructs per week, and thousands per year, for preclinical and clinical testing — with a cycle time of a handful of weeks;
Automated high throughput, enabling rapid scientific advances in our mRNA Therapeutics
Unique levels of control and versatility, with the ability to adjust and course correct with speed, enabled by constant robotic reporting and data-generation.
At Moderna, we are on our way toward reducing the drug manufacturing cycle from weeks or months to just days — speeding our own mRNA scientific research efforts as well as those of our growing number of partners and ventures.
2 vaccines mRNA based in clinical trials
30 days to make a personalized cancer vaccine (working with Merck), in clinic next year
Rare genetic diseases
Regenerative medicine Grow back heart tissue after heart attack
Clinical trial in the fall in germany
FDA is improving by starting better balance risk and reward