Two Antiaging Treatments in Phase 3 Clinical Trials

Lifespan.io has a list of antiaging treatments and their stage of clinical approval.

There are two treatments in phase 3 clinical trials and four in phase 2 clinical trials.

The phase 2 clinical trials are two senescent cell treatments and two stem cell treatments. Phase 3 are a TOR inhibitor and a stem cell treatment.

ResTORbio has RTB101, an oral medication that inhibits target of rapamycin complex 1 (TORC1) in stage 3 clinical trials. They are using a combination of RTB101 and everolimus, another TORC1 inhibitor. They are using the treatment to fight respiratory tract infections in the elderly and improving the immune system rather than attempting to target individual infectious agents. The phase 2b trial of RTB101 reduced the number of elderly people who had infections versus the control group.

The mammalian target of rapamycin (mTOR) pathway uses the multiprotein complexes TORC1 and TORC2 to conduct signaling.

Wnt Pathway for Healthier Stem Cells

Samumed is developing drugs for multiple degenerative diseases, including osteoarthritis, alopecia (baldness), and degenerative disc disease. While these therapies differ from each other, they all focus on restoring the Wnt signaling pathway.

The Wnt pathway is fundamental in stem cell differentiation. It allows for ordinary tissue repair and upkeep, and it provides for wound healing and recovery from injuries. However, like many other pathways, it becomes deregulated with age. By restoring this pathway, Samumed intends to replenish deteriorating tissues with the body’s own cells, staving off age-related diseases.

21 thoughts on “Two Antiaging Treatments in Phase 3 Clinical Trials”

  1. This one is interesting.

    “The Wnt pathway is fundamental in stem cell differentiation. It allows for ordinary tissue repair and upkeep, and it provides for wound healing and recovery from injuries. However, like many other pathways, it becomes deregulated with age. By restoring this pathway, Samumed intends to replenish deteriorating tissues with the body’s own cells, staving off age-related diseases.”

    Does nothing about the telerome length limit, but promises to extend “healthspan”. As a sufferer of MPB, I do the Minoxidil/Propecia thing. I added micro-needling to that a few months ago. In theory, it stimulates the Wnt pathway. I can say that the results at month 3 are pretty good. Much better than the other two methods alone (50% increase in hair count, plus these are new hairs not just reactivated miniaturized hairs).

    Stepping aside from MPB and extending that to other things impacted by the Wnt response, I think that’s pretty exciting. Rejuvenate an organ or something. I suspect that if not this one, similar therapies will extend the human healthspan to the telerome limit.. somewhere around 120 years.

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  2. To reverse aging we would need to treat the seven or nine causes of aging. Senescent cells seem to be the root cause of aging so dealing with these first, and perhaps at a young age, would be the best way forward.

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  3. Been following a lot of this for years. This is a good link. Makes it easier to keep up with and adds a few I wasn’t aware of.

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  4. That is 100 mg. They have moved on and sell 300 mg now. I suspect 100 mg is too little. Though maybe the lower dose is fine for people who are still relatively young. I suspect 300 mg is inadequate as well…to tell the truth. Many of the studies are using more. But at the price…well…that is just a lot of money.

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  5. There are three forms of niacin. I suspect if the other two did the same thing we would already know about that. NR was discovered in 2004 and has been shown to greatly boost NAD+ in humans.

    “Nicotinamide” is just Niacinamide. Been around forever. But who knows, maybe you can get away with taking a bunch of “nicotinamide”. I think supplement sellers are trying to catch people looking for Nicotinamide riboside trying to save a buck by changing the label of Niacinamide to Nicotinamide.

    I know people have been taking astragalus as it is the source for the telomere extension stuff. But it probably does nothing, as there just is not enough. And similarly there have been people taking this for a long time. If it did something in that form, we would already know about it. I think these shortcuts can work sometimes. But you are still spending money and maybe it does something and maybe it doesn’t.

    If you are young, I suppose it does not matter that much. If you are old, it is probably not a smart gamble, unless there was no way you could afford the real thing anyway…or you have to give away your pets or give up something else that makes life worth living.

    In any case, don’t be suckered by “Nicotinamide” sellers, as Niacinamide is exactly the same thing and much cheaper yet. The supplement sellers never used the name Nicotinamide until after Nicotinamide riboside came out. https://en.wikipedia.org/wiki/Vitamin_B3

    Can’t say what I really think about these companies

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  6. Wouldn’t it be about as effective to simply take nicotinamide, the amide (NH2) form of niacin: vit B3.
    Our bodies can make NAD (the di-nucleotide, which has a hard time passing our intestinal wall anyway) out of NMN (the mono-nucleotide), which in turn can come from nicotinamide.

    I take 100 mg of the nicotinamide form of vit. B3 per day. Cheap and easy.

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  7. Source for that 750mg figure?
    AFAIK, for most of supplements, dosage follow this 2 simple rules: (1) you have to take a minimum, critical quantity to see any effect at all, and (2) once you above the threshold, the results/effect curve follow the classic Pareto law: with 20% on the stuff you get 80% of the benefits.
    On top of this, Pomelo and Grapefruit juice can boost the effects of most supplements by breaking down a key liver enzyme.

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  8. Source for that 750mg figure?
    AFAIK, for most of supplements, dosage follow this 2 simple rules: (1) you have to take a minimum, critical quantity to see any effect at all, and (2) once you above the threshold, the results/effect curve follow the classic Pareto law: with 20% on the stuff you get 80% of the benefits.
    On top of this, Pomelo and Grapefruit juice can boost the effects of most supplements by breaking down a key liver enzyme.

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  9. You need to take like 750mg per day for that to really work at its best. So more like $135 for a month supply at that price.

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  10. if overdosed for a long period rats get cancer .

    as for getting those…

    Querceting is available and not expensive (ymmv)

    Fistetin is unregulated; also freely sold (hard to find good suppliers, though) . Dasatinib requires doctors prescription and costs about 100-200$ per treatment. Also it has nasty side effects and might cause more harm than good.

    fisetin + quercetin can be ordered online. The human equivalent dose of fisetin would be about 2.1 g /day. The recommended dose as food supplement is 100 mg (20 times less). Both quercetin and fisetin have very crappy water solubility and don’t get absorbed much. Hence they are safe, since you just pass it to the white throne..

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  11. I researched Quercetin, last year, and found it at some health food stores. Caution: you shouldn’t take it continuously.

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  12. I wish there was a mutual fund that just invests in life extension…just a wide range of these technologies, as it is unclear what is really going to work well in humans. I bought stock in ChromaDex (CDXC). They make NR (nicotinamide riboside) which boosts NAD+ in cells. There are decent reviews at Yahoo…yes…you can buy the stuff legally. At least in the U.S., Canada, and some other countries. $47.25/bottle which seems a bit steep to me. I suspect they could sell tons of this stuff at $20/bottle. https://www.amazon.com/TRU-NIAGEN-Advanced-Nicotinamide-Increases/dp/B01IMF8D2Q/ref=sr_1_3?crid=10RS0JI164H6Y&keywords=niagen%2Bnicotinamide%2Briboside&qid=1560116135&s=gateway&sprefix=niagen%2Caps%2C214&sr=8-3&th=1
    Mostly people are taking it for anti-aging and to assist in muscle strain recovery.
    I took some for a time. I do think it helped muscle strain…not much else. I did not have loads of energy or anything, but I may not be old enough…my Mom is convinced it works.
    Personally, I think its main use is going to be in early development: farm animals, human pregnancy, nursing, even fertility.

    https://www.feedstuffs.com/nutrition-health/vitamin-compound-may-encourage-growth-chickens

    https://finance.yahoo.com/news/study-shows-supplementation-nicotinamide-riboside-113000390.html

    But I really would like to invest in a mutual fund that is investing in all the small anti-aging companies I can’t hope to get good information on.

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