Supercomputer Model Identifies Pathways and Possible Weaknesses of COVID-19

Oak Ridge National Laboratory supercomputer modeling analysis suggests COVID-19 causes the inflammatory molecule bradykinin to run amuck in the human body. The Bradykinin storm cause gel to form in the lungs and the blood vessels to leak. The same analysis identifies about ten interventions to reduce the severity of COVID-19. An easy precaution is to take some Vitamin D. This will not prevent COVID-19 but might help reduce the chance for a severe case and reduce the severity of it.

Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow wrote the researchELife – A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

The data shows COVID-19 increases production of hyaluronic acid (HLA) in the lungs. HLA is often used in soaps and lotions for its ability to absorb more than 1,000 times its weight in fluid. When it combines with fluid leaking into the lungs, the results are disastrous: It forms a hydrogel, which can fill the lungs in some patients. This becomes like trying to breathe through Jell-O.

The renin–angiotensin system (RAS) controls many aspects of the circulatory system, including the body’s levels of a chemical called bradykinin, which normally helps to regulate blood pressure. According to the team’s analysis, when the virus tweaks the RAS, it causes the body’s mechanisms for regulating bradykinin to go haywire. Bradykinin receptors are resensitized, and the body also stops effectively breaking down bradykinin.

The bradykinin hypothesis provides a model that provides a better understanding COVID-19. It predicts nearly all the disease’s symptoms, even bruises on the toes that at first appear random.

Potential interventions
Several interventional points (most of them already FDA-approved pharmaceuticals) could be explored with the goal of increasing ACE, decreasing BK, or blocking BK2 receptors.

Several drugs target aspects of the RAS and are already FDA approved to treat other conditions. They could be applied to treating Covid-19 as well. Danazol, stanozolol, and ecallantide reduce bradykinin production and could potentially stop a deadly bradykinin storm.

Icatibant reduces bradykinin signaling and could blunt its effects once it’s already in the body.

Vitamin D is a potentially useful Covid-19 drug. It could stop potentially deadly bradykinin storms from forming. Vitamin D has already been shown to help those with Covid-19. Around 20% of the US population is Vitamin D deficient. This is a relatively safe way to reduce the severity of the virus.

Other compounds could treat symptoms associated with bradykinin storms. Hymecromone, for example, could reduce hyaluronic acid levels, potentially stopping deadly hydrogels from forming in the lungs. And timbetasin could mimic the mechanism that the researchers believe protects women from more severe Covid-19 infections. The potential treatments will need to be studied in a rigorous, controlled environment before their effectiveness could be determined and they could be used more broadly.

Functionally annotated network of genes involved in the hypertension-hypotension axis whose expression across the GTEx population is correlated and anticorrelated with the AGTR1 and AGTR2 receptors.

Critically disrupted RAS and Bradykinin pathways in COVID-19 BAL samples.

SOURCES- Oak Ridge National Lab, E-life, The Scientist, Medium
Written By Brian Wang,

20 thoughts on “Supercomputer Model Identifies Pathways and Possible Weaknesses of COVID-19”

  1. does it look like jello or a blood clot. Very early on doctors did nortice clotting in bloodiest on autopsies. The use anti coagulants ion Corvid 19 patients is now common. And depending on the type of clot it could look like Jello.

  2. That article does not support your claim that "The health benefits of sunlight go beyond increased levels of Vitamin D.
    The sunlight is a vibration that our body is attuned to and helps it work better."
    I have heard conjecture from one scientist that it helps allow the body to use sulfur better:
    But she is not a nutritionist or biologist by training, and no one as far as I know is following up on this.
    That said, sulfur does appear to have been neglected in human health.

  3. Dang, hyaluronic acid is great for joint, skin and eye health, and strengthens bones too.
    Also odd, in that production of hyaluronic acid falls off in old age.

  4. I dunno, it was previously described/reported as a situation where ACE2 inhibition was causing a different surfacecant effect in the lungs causing the fluid filled lungs. Perhaps identifying/differentiating the hydrogel presence isn't easy?

  5. Wouldn't the "jello lung" have been pretty obvious from the first autopsy?
    And someone tested the stuff as obviously important?

  6. Identifying hyaluronic acid is kinda big for dealing with the whole breathing/ventilator problem. If you can dissolve the resulting hydrogel easily, that improves the situation considerably, and avoids needing to put people on ECMO.

    But the RAS/ACE2 part is kinda bad though. Why? Because ACE2 inhibitors are commonly prescribed for high blood pressure. In the US, where that is a common health issue, that means people were effectively priming themselves for faster COVID-19 symptoms.

    The part where bradykinin messes up the blood-brain barrier is also concerning, along with how it messes with the heart as well.

    I also find it highly amusing that Summit (number 2 supercomputer) was used for this, while Fugaku (number 1 supercomputer) in japan was busy modeling air droplet dispersion in constrained settings like while wearing a mask, or when your open plan office has a partial desk partition…

  7. Sunlight also reduces transmission rate, maybe there would have be no epidemic if we ere told to spend 20-30 min a day in the afternoon sunlight.

    The health benefits of sunlight go beyond increased levels of Vitamin D. The sunlight is a vibration that our body is attuned to and helps it work better.

  8. Good News. So even if the vaccines take another year to develop, test, manufacture and figure out how to distribute, if we have effective treatments we should be able to bring the death rate of Covid to near zero. How quickly still remains to be seen. As Covid seems like it will circulate in the population for many years these treatments will be needed.

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