A Coherent, Executable Plan to Achieve Unlimited Healthy Lifespan

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The Longevity Biotech Fellowship is a group of scientists, entrepreneurs, funders, and institutional allies who cooperate to advance biotechnology to reverse aging and extend human healthspan. This group is sponsored by 100 Plus Capital.

Mark Hamalainen is cofounder of the Longevity Biotech Fellowship. His career has progressed from manual bench work in academia, to lab automation at Synthego, to longevity movement building – always seeking better methods and higher leverage ways to accelerate progress.

There is making people healthier with known things that will increase healthspan. This is things like good diet, exercise and creating ways to optimize this and make it easier for more people to follow. This and better drugs could achieve about 10-20 years of more overall life expectancy and it should be healthier years.

Mark also has targeted a comprehensive organ and cell replacement approach. This approach could be perfected with a $2.5 billion program. This would also involve gradual incremental brain replacement. This would need to be comprehensive organ replacement that is more effective than current organ replacement. The main plan is to follow Jean Hebert Lab to grow bodies without brains by using CRISPR to knockout neocortex development genes. This would be proven in monkeys and then used on humans. There would need to be successful brain transplant surgery and reconnection of nerves and spinal cord.

6-10 brain replacement surgeries over 20 years would enable full brain replacement. The brainless body would grow on life support until the skull was large enough for transplant.

It estimated that it will take about a $125 billion to master cryostasis (freezing) people to pause life.

Bioengineering is the biotech gene editing and epigenetic approaches. There is a more detailed (but not comprehensive) roadmap of biotech rejuvenation projects.

8 thoughts on “A Coherent, Executable Plan to Achieve Unlimited Healthy Lifespan”

  1. The issue is “would the consciousness that is you right here, right now” be experiencing its new post-biological life or would it be an AI running in some machine with your memories and experiences that was copied and stored in whatever data storage that can handle it. Any scanning technique that doesn’t damage the neurons and pathways in recording and formatting the information for an electronic device is making a copy rather than moving the essence of the person.

    I know quantum teleportation does destroy the information of the original particle in order to transfer the information to the other, but that’s imparting the quantum state of one particle to another. This wouldn’t be an upload but rather a Star Trek-esque transporter. The way it would work is that the crew before beaming down would have their bodies disintegrated in the process of scanning and reassembled by something more akin to a Trek replicator with all of the needed elements kept in storage to replicate/transport away teams if Trek teleportation worked the same way as IRL “teleportation” does. It would not be useful for “uploading” minds as the stored data in your head would have to be formatted for a machine. Quantum teleportation of human neurons would result in the re-creation of those same neurons and along with the rest of the human.

  2. Dogs may get enhanced lifespans before humans do:

    “Now, the San Francisco-based biotech company Loyal has announced its anti-aging drug for canines cleared the first of several hurdles needed for approval by the Food and Drug Administration. While the drug still must undergo clinical trials, this marks the first time the FDA has indicated a willingness to endorse longevity drugs, writes Hilary Brueck for Business Insider.”

    See:

    https://www.smithsonianmag.com/smart-news/a-new-drug-that-could-extend-dogs-lives-inches-closer-to-approval-180983331/

  3. Intriguingly, a new report on drugs to treat Covid brain fog may show ways to clear senescent brain cells as well:
    https://newatlas.com/medical/four-existing-drugs-may-reverse-premature-brain-aging-covid-19/
    “Experimenting on lab-grown mini-brains and mice, researchers have found that SARS-CoV-19 infection can cause ‘zombie’ cells to accumulate, contributing to the brain fog associated with long COVID, and have identified drugs that can reverse this virus-related premature aging.”
    I think the study’s use of brain organoids points to a better option for regrowing a brain or at least parts of it, than the ghoulish 20-year brainless – in both sense of the word – concept discussed here, provided a perfect neural map of the brain can be made to the atomic level (well, that’s what they had to do for the Star Trek transporters, isn’t it? They basically reconstituted an entire body from the atomic level every time someone was transported. It’s odd they never thought to make someone younger or healthier along the way).
    This reminds me of the doctor who wants to do a human head transplant; he’s already done so with rats, monkey and dogs: https://nypost.com/2017/11/17/professor-claims-doctors-successfully-performed-human-head-transplant/
    The paralyzed volunteer mentioned in this article later backed out. Dr. Sergio Canavero, chief of the Turin Advanced Neuromodulation Group, is still looking AFAIK.

  4. Headless bodies grown like vegetables?
    I doubt it will work at all since the brain controls a lot of the metabolism. Bodies also need to move and have resistance training to function. Our current bodies are good evidence of that.

  5. Are people really satisfied with the human body as the forever ‘omega goal’?
    It seems to me that the most versatile and future-proof tech would be ‘essence upload’ (the only real You) – your lifetime of experiences = memories + skills stored and then transferred to whatever preferred sensory/action vessel – ideally an Iain Banks’ Culture series ‘Super Sapient’ ASI spacecraft.

    • The problem with uploading is that, for it to give you immortality, your personality would have to be “tangible”. Essentially, you would need a soul or a “you” that exists independently from the body. The problem is that there is no evidence for the existence of the soul. Unless a soul exists and it is something that can be separated from the body and transplanted, an upload is just a copy. It would be an AI with your memories and personality that may even think it is you but it is not you. Think less like soul migration and more “The Sixth Day” starring Arnold Schwarzenegger where the clones in the movie have the memories and personality of the original imprinted on them after the original had been mind-scanned and that both can exist independently of each other. You wouldn’t notice the difference. You would still be in the same body. That’s why they work so hard to keep the meatsuit going as you’re sort of stuck in it. Now, some people postulate that it may be possible to replace you but it would be bit by bit until you are a purely mechanical being based on the old Greek paradox where a boat, over a period of time, has its wooden planks and sails replace to the point where none of the original material is left leading to the philosophical question if it is the same boat. I have heard that none of the original atoms that composed our bodies at birth are still a part of us. So *maybe* this slow replacement process is how the actual “you” will become post-biological.

      • Thanks for your feedback – but not sure that it matters if the personality ‘data’ exists in multiple locations or not. It may diverge in each separate instance, You, You’, You”, etc., etc., with time, but the key concept of that at the time of ‘mind scan’ is that your personality is just data – the simple software-hardware dynamic – you are no more or less than a spreadsheet on a hard drive. So if you buy into the idea that the spreadsheet data on a drive is ‘tangible’ or simply a spreadsheet ‘spirit/ soul’ whatever. Perhaps then, the only question is do you want to run on a crappy Apple 2 machine from the 80s – current human body -or- the next best thing – some silicon, super system capable of great ranges of EM sensor perception, awesome abilities to travel, process, communicate, etc., etc.
        I may be missing something from your comment, such as the exact form of data that a personality could be – not magnetically-encoded bits – obviously, perhaps quantum-spin states (revealing my ignorance of qunatum physics)…

        • The issue is “would the consciousness that is you right here, right now” be experiencing its new post-biological life or would it be an AI running in some machine with your memories and experiences that was copied and stored in whatever data storage that can handle it. Any scanning technique that doesn’t damage the neurons and pathways in recording and formatting the information for an electronic device is making a copy rather than moving the essence of the person.

          I know quantum teleportation does destroy the information of the original particle in order to transfer the information to the other, but that’s imparting the quantum state of one particle to another. This wouldn’t be an upload but rather a Star Trek-esque transporter. The way it would work is that the crew before beaming down would have their bodies disintegrated in the process of scanning and reassembled by something more akin to a Trek replicator with all of the needed elements kept in storage to replicate/transport away teams if Trek teleportation worked the same way as IRL “teleportation” does. It would not be useful for “uploading” minds as the stored data in your head would have to be formatted for a machine. Quantum teleportation of human neurons would result in the re-creation of those same neurons and along with the rest of the human.

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