After I, Brian Wang, took Rejuvant, time released AKG a second aging biomarker test and a spit test analysis showed my biological age decreased by about 4 years.
I feel good and healthy now and during my time taking the supplement. However, I cannot directly correlate good energy levels and any feelings of well being directly to the supplements. There were no negative effects. The most important actions for good aging are still healthy eating habits, exercise and good sleep. I am almost 60 and there are billions of dollars and hundreds of companies now working on aging damage repair. I will be closely monitoring all of the scientific results of the antiaging treatments and I plan to continue another round of AKG. I plan to continue looking for other antiaging treatments.
I will continue to try to increase my exercise levels which currently is four weekly 60-75 minute sessions of group exercise. This included one or two yoga sessions. Yoga has been good for eliminating my need for chiropractic neck and back adjustments. It has been good for increasing spinal mobility. I need to increase resistance training and shift my diet to about 20-30% more protein.
Maintaining good health while getting older is not easy and gets harder. Metabolism decreases so it becomes harder to avoid getting heavier.
There are many youtube videos giving advice on lowering body fat percentages when over 50.
A good diet is the most important aspect. Controlling portion size (don’t overeat) and reducing calories from alcohol and sweets.
Followers of Nextbigfuture can go to
https://rejuvantsale.com/
Use code BIGFUTURE for a discount, if you want to try the supplement.
I, Brian Wang, took Rejuvant time released AKG. AKG is safely used by millions for bodybuilders and athletes. Time-released AKG from Rejuvant is used for healthier aging.
I took Rejuvant for six months. I started with an aging biomarker test and a spit test analysis. The first analysis found that I had genetics that reduced my absorption of Vitamin B. I am now taking Vitamin B supplements along with Rejuvant. The first aging biomarket test had my biological age matching my chronological age.
Rejuvant has human medical studies where aging biomarkers have been reversed to reduce measured biological age. There is more than the single case as the study looked at hundreds of people.
This chart shows the measurements. There are error bars but the midpoints indicate that over a three 6 months courses of using Rejuvant every day he has his measured biological age reduce from 52 down to 45. Tom Weldon is 67 years old. If this is accurate, then it would suggest he is squaring the health curve. According to biomarkers he is getting substantially healthier.
I would interpret effect to mean that people can be healthier up to as much as 80 to 95 but then aging damage still reaches critical levels to cause aging diseases.
I would cite the example of the fitness guru, Jack LaLanne. Jack was fanatical about eating right and exercising. Jack has amazing feats of fitness into his 80s. National University of Singapore to study this as part of means to achieve a five-year increase in healthspan for all people in Singapore. Kennedy is collaborating with Rejuvant.
Brian Kennedy indicates he agrees with the Aubrey dr Grey / SENS analysis of seven kinds of aging damage.
The first research theme funded under the ‘Hacking Aging’ initiative is a series of clinical studies to test novel nutritional supplements and repurposed drugs to slow ageing in middle-aged adults (40-60 years).
At least 15 biomarker studies are ongoing, including Project Abios (Ageing Biomarker Study in Singaporeans) which is looking at several hundred biomarkers in 420 to 450 participants.
The second research theme is to use deep omics data to personalize these supplements and repurposed drugs and other interventions for optimal healthspan extension in middle-aged participants.
One of the supplements is alpha-ketoglutarate, which has been shown to increase the healthspan – the period of life spent in good health – and lifespan in mice. The centre will be investigating whether six months of daily supplementation can slow biological aging and initial results are estimated to be available in a year’s time, said Professor Andrea Maier, the centre’s co-director. Repurposed drugs include metformin, a well-known drug used to treat Type 2 diabetes, that may be able to slow ageing.
The third research theme focuses on extending healthspan in older adults through strength training exercise, harnessing the Foundation’s Gym Tonic community of seniors.
Professor Brian Kennedy, internationally recognized for his research into the biology of aging and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human aging and its associated diseases, is helming the Centre with co-director, Professor Andrea Maier, an internal medicine specialist renowned for translational research in aging and age-related diseases diagnostics and pharmacological and non-pharmacological interventions in aging humans.
The 1,600 square feet Centre for Healthy Longevity (CHL) located at Alexandra Hospital, will conduct trials and execute validation studies with healthy participants from the age of 30 years. The Centre will also develop and test these interventions using newly identified biomarkers of human aging. Once approaches are validated, the Centre will develop strategies that integrate a combination of nutritional and exercise approaches together with supplements and (repurposed) drugs for personalized adoption in the Singapore population. The ultimate goal is to bring the individual closer to his/her state of optimal peak performance during the entire lifespan (e.g. screening to start from 30 years of age).
CHL will be looking at blood-based biomarkers, probably the most investigated group due to the large amount of data accumulated in clinical trials.
Many Well Funded Efforts
There are many well funded antiaging efforts. Saudi Arabia has the Hevolution fund which invests $1 billion every year into antiaging.
There are over 158 companies working on antiaging. There are over 340 clinical trials. They have a market cap of over $6 billion. They have over $10 billion in funding. There are over 5000 employees at the antiaging companies.
Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.
Known for identifying cutting edge technologies, he is currently a Co-Founder of a startup and fundraiser for high potential early-stage companies. He is the Head of Research for Allocations for deep technology investments and an Angel Investor at Space Angels.
A frequent speaker at corporations, he has been a TEDx speaker, a Singularity University speaker and guest at numerous interviews for radio and podcasts. He is open to public speaking and advising engagements.
I started taking it, also, the first time Bryan posted on it. The first test said my bio age was three years younger, the second test said it was now six under.
There were no negative side effects (other than I hate the size of these monsters).
My joints improved hugely. For several years I had pain in my knees whenever going down hill or down steps. It is gone. My lower back is much improved. My neck no longer gives me any bother no matter what angle I hold it at. If these improvements were caused by the pills and they were the only benefits, I would keep taking it. Since I don’t know and because there may be other benefits, I will keep taking it.
I already took a lot of carefully chosen supplements, and a couple of prescriptions. The cost would have freaked me out back when I was younger but that’s not been an issue for some time.
Looks interesting, will you continue to take it and then do another one? If you will stop taking it would be very interesting to take another biomarker few months later to see if the effects are longer lasting or they decline rapidly?
B vitamins have odd effects on gut flora.
1) While enhanced folate (B9) production is associated with longevity in lab models, oral supplementation has had the opposite effect because of the way the folate is metabolized by the microbiome – although this has not been tested A) on humans in trials or B) for the folinic acid form.
2) Ingested cobalamins (B12) are actually inflammatory (hence the notorious acne from taking B12 orally) because of the way gut flora use them to produce porphyrins. Take as a lozenge or, better still, inject if possible.
3) Though your upper limit on thiamine (B1) absorption is pretty low, benfotiamine has no such limit and is converted by your cells to thiamine. Benfotiamine is extraordinarily useful against aging as a Nrf2 inducer (>500mg daily) and has excellent antidiabetic, antiinflammatory, anti-neuropathy and (probably) anticancer properties. However, as I discovered when I quit taking B1 briefly, thiamine itself is also absorbed and process by friendly flora that feed on it, use it to digest inulin and expand – which could be very helpful in antiaging. I don’t know that these flora have an upper limit on absorption but I presume at some point excess B1 consumption might prompt biofilm formation – never a good idea even with friendly flora.
4) Similar problems exist for betaine, choline and carnitine consumption in some, but not all or maybe even most humans. In these unlucky people, gut flora process these methylators into inflammatory TMAO.
Recall my earlier comments and warnings about taking AKG.
Thanks for that interesting info.
Well, the biomarker results certainly look promising.
As I’ve noted before, Rejuvant is just a mixture of time release AK, vitamin A, and Calcium, sold with a biomarker test. Individually they’re cheaper, and if you’re already careful about your nutrition, the vitamin A and calcium are redundant.
The time release feature IS quite important, the half life of AKG in the bloodstream is very short, on the order of minutes, it gets metabolized away very rapidly. It’s enough to make me wonder if more frequent dosing wouldn’t be advisable; Did they provide any information on the serum profile over time with the dosing schedule? I’m actually kind of surprised they didn’t advise taking 1 tablet every 12 hours instead of 2 in the morning.
Anyway, you’ve sold me on trying time release AKG, at least, if not brand name Rejuvant. Gonna have to shop for a bigger pill case now…
Hello Brian , thx for sharing, did fastening time to time?
For independent verification I would want to deal with 2 separate companies. One company providing the supplements/treatments. Another company analyzing your biological age. If they are one and the same it’s too easy to game or mislead (even unintentionally).
Hope it works though because I’m not too far behind you age wise.
Exactly!
There is a huge amount of money in this and manipulating the biomarker test to show a positive trend will yield a substantial short term profit from continued subscriptions and anecdotal marketing like this article.
Independent verification is the name of the game in all science.
I am pretty sure they use a 3rd party to test the biological age portion as it’s not their company.